4ZDQ
Crystal Structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) from Burkholderia thailandensis complexed with CTP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0008299 | biological_process | isoprenoid biosynthetic process |
A | 0016779 | molecular_function | nucleotidyltransferase activity |
A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
A | 0050518 | molecular_function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
A | 0070567 | molecular_function | cytidylyltransferase activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0008299 | biological_process | isoprenoid biosynthetic process |
B | 0016779 | molecular_function | nucleotidyltransferase activity |
B | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
B | 0050518 | molecular_function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
B | 0070567 | molecular_function | cytidylyltransferase activity |
C | 0003824 | molecular_function | catalytic activity |
C | 0008299 | biological_process | isoprenoid biosynthetic process |
C | 0016779 | molecular_function | nucleotidyltransferase activity |
C | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
C | 0050518 | molecular_function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
C | 0070567 | molecular_function | cytidylyltransferase activity |
D | 0003824 | molecular_function | catalytic activity |
D | 0008299 | biological_process | isoprenoid biosynthetic process |
D | 0016779 | molecular_function | nucleotidyltransferase activity |
D | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
D | 0050518 | molecular_function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
D | 0070567 | molecular_function | cytidylyltransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 21 |
Details | binding site for residue CTP A 301 |
Chain | Residue |
A | PRO10 |
A | GLY79 |
A | ALA80 |
A | SER81 |
A | ARG82 |
A | SER85 |
A | ASP108 |
A | ALA109 |
A | ALA110 |
A | LYS215 |
A | MG302 |
A | CYS11 |
A | HOH405 |
A | HOH429 |
A | ALA12 |
A | GLY13 |
A | THR14 |
A | GLY15 |
A | SER16 |
A | ARG17 |
A | LYS24 |
site_id | AC2 |
Number of Residues | 3 |
Details | binding site for residue MG A 302 |
Chain | Residue |
A | CTP301 |
A | HOH448 |
A | HOH454 |
site_id | AC3 |
Number of Residues | 1 |
Details | binding site for residue ACT A 303 |
Chain | Residue |
A | GLY69 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue ACT A 304 |
Chain | Residue |
A | ARG82 |
A | ASP108 |
A | ARG111 |
A | THR191 |
A | LYS215 |
A | HOH420 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue ACT A 305 |
Chain | Residue |
A | VAL74 |
A | ARG75 |
A | HOH445 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue ACT A 306 |
Chain | Residue |
A | ASP141 |
B | GLN166 |
B | PHE214 |
B | LYS215 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue ACT A 307 |
Chain | Residue |
A | ASP223 |
B | ARG212 |
B | HIS231 |
site_id | AC8 |
Number of Residues | 3 |
Details | binding site for residue ACT C 301 |
Chain | Residue |
C | THR142 |
D | ARG111 |
D | ALA165 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue ACT C 302 |
Chain | Residue |
C | ASP100 |
C | ALA101 |
C | ARG172 |
C | MET175 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue ACT C 303 |
Chain | Residue |
C | ALA12 |
C | SER81 |
C | ARG82 |
C | SER85 |
site_id | AD2 |
Number of Residues | 3 |
Details | binding site for residue CAD C 304 |
Chain | Residue |
C | GLY69 |
C | LEU185 |
C | GLU186 |
site_id | AD3 |
Number of Residues | 12 |
Details | binding site for residue CTP D 301 |
Chain | Residue |
D | PRO10 |
D | CYS11 |
D | ALA12 |
D | LYS24 |
D | GLY79 |
D | ALA80 |
D | SER81 |
D | ARG82 |
D | SER85 |
D | ALA109 |
D | ALA110 |
D | MG302 |
site_id | AD4 |
Number of Residues | 1 |
Details | binding site for residue MG D 302 |
Chain | Residue |
D | CTP301 |
site_id | AD5 |
Number of Residues | 4 |
Details | binding site for residue ACT D 303 |
Chain | Residue |
C | ARG111 |
C | PHE214 |
C | LYS215 |
D | ASP141 |
site_id | AD6 |
Number of Residues | 3 |
Details | binding site for residue ACT D 304 |
Chain | Residue |
C | ASN160 |
D | PRO147 |
D | ALA148 |
site_id | AD7 |
Number of Residues | 2 |
Details | binding site for residue GOL D 305 |
Chain | Residue |
D | ASP43 |
D | GLY69 |
Functional Information from PROSITE/UniProt
site_id | PS01295 |
Number of Residues | 8 |
Details | ISPD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. VLVHDAAR |
Chain | Residue | Details |
A | VAL104-ARG111 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | SITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00108 |
Chain | Residue | Details |
A | ARG17 | |
A | LYS24 | |
B | ARG17 | |
B | LYS24 | |
C | ARG17 | |
C | LYS24 | |
D | ARG17 | |
D | LYS24 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | SITE: Positions MEP for the nucleophilic attack => ECO:0000255|HAMAP-Rule:MF_00108 |
Chain | Residue | Details |
A | ARG159 | |
A | LYS215 | |
B | ARG159 | |
B | LYS215 | |
C | ARG159 | |
C | LYS215 | |
D | ARG159 | |
D | LYS215 |