4ZBE

Crystal structure of KPC-2 beta-lactamase complexed with avibactam

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0030655	biological_process	beta-lactam antibiotic catabolic process
A	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CIT A 301

Chain	Residue
A	ARG160
A	LYS211
A	ALA229
A	TRP250
A	HOH465

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site_id	AC2
Number of Residues	16
Details	binding site for residue NXL A 302

Chain	Residue
A	ASN131
A	GLU165
A	ASN169
A	THR215
A	LYS233
A	THR234
A	GLY235
A	THR236
A	ARG254
A	HOH401
A	HOH543
A	HOH554
A	CYS68
A	SER69
A	LYS72
A	SER129

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile; acyl-ester intermediate => ECO:0000269|PubMed:33257320, ECO:0007744|PDB:6Z23, ECO:0007744|PDB:6Z24

Chain	Residue	Details
A	SER69

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	GLU167

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:28388065, ECO:0000269|PubMed:33257320, ECO:0007744|PDB:5UJ3, ECO:0007744|PDB:6Z23, ECO:0007744|PDB:6Z24

Chain	Residue	Details
A	SER69
A	THR236

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:28388065, ECO:0007744|PDB:5UJ3

Chain	Residue	Details
A	LYS72

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:33257320, ECO:0000312|PDB:6Z24

Chain	Residue	Details
A	TRP104

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:28388065, ECO:0000269|PubMed:33257320, ECO:0007744|PDB:5UJ3, ECO:0007744|PDB:6Z23

Chain	Residue	Details
A	SER129

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:33257320, ECO:0007744|PDB:6Z23, ECO:0007744|PDB:6Z24

Chain	Residue	Details
A	ASN131

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:28388065, ECO:0007744|PDB:5UJ3, ECO:0007744|PDB:6Z24

Chain	Residue	Details
A	THR234

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