Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4Z90

ELIC bound with the anesthetic isoflurane in the resting state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042391	biological_process	regulation of membrane potential
A	0042802	molecular_function	identical protein binding
A	0043005	cellular_component	neuron projection
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0007165	biological_process	signal transduction
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042391	biological_process	regulation of membrane potential
B	0042802	molecular_function	identical protein binding
B	0043005	cellular_component	neuron projection
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0007165	biological_process	signal transduction
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042391	biological_process	regulation of membrane potential
C	0042802	molecular_function	identical protein binding
C	0043005	cellular_component	neuron projection
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0007165	biological_process	signal transduction
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042391	biological_process	regulation of membrane potential
D	0042802	molecular_function	identical protein binding
D	0043005	cellular_component	neuron projection
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0007165	biological_process	signal transduction
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0042391	biological_process	regulation of membrane potential
E	0042802	molecular_function	identical protein binding
E	0043005	cellular_component	neuron projection
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0006811	biological_process	monoatomic ion transport
F	0007165	biological_process	signal transduction
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0042391	biological_process	regulation of membrane potential
F	0042802	molecular_function	identical protein binding
F	0043005	cellular_component	neuron projection
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
G	0006811	biological_process	monoatomic ion transport
G	0007165	biological_process	signal transduction
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0042391	biological_process	regulation of membrane potential
G	0042802	molecular_function	identical protein binding
G	0043005	cellular_component	neuron projection
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
H	0006811	biological_process	monoatomic ion transport
H	0007165	biological_process	signal transduction
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0042391	biological_process	regulation of membrane potential
H	0042802	molecular_function	identical protein binding
H	0043005	cellular_component	neuron projection
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005216	molecular_function	monoatomic ion channel activity
I	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
I	0006811	biological_process	monoatomic ion transport
I	0007165	biological_process	signal transduction
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
I	0042391	biological_process	regulation of membrane potential
I	0042802	molecular_function	identical protein binding
I	0043005	cellular_component	neuron projection
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005216	molecular_function	monoatomic ion channel activity
J	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
J	0006811	biological_process	monoatomic ion transport
J	0007165	biological_process	signal transduction
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport
J	0042391	biological_process	regulation of membrane potential
J	0042802	molecular_function	identical protein binding
J	0043005	cellular_component	neuron projection

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue 4LE A 401

Chain	Residue
A	LEU240
A	ALA244
C	ALA244
D	LEU240
E	ALA244

site_id	AC2
Number of Residues	4
Details	binding site for residue MES A 402

Chain	Residue
A	TRP206
A	HOH506
B	THR259
B	GLN264

site_id	AC3
Number of Residues	3
Details	binding site for residue MES A 403

Chain	Residue
A	THR259
A	GLN264
E	TRP206

site_id	AC4
Number of Residues	4
Details	binding site for residue MES B 401

Chain	Residue
B	SER202
B	TRP206
C	THR259
C	GLN264

site_id	AC5
Number of Residues	3
Details	binding site for residue MES C 401

Chain	Residue
C	TRP206
D	THR259
D	GLN264

site_id	AC6
Number of Residues	3
Details	binding site for residue MES D 401

Chain	Residue
D	TRP206
E	THR259
E	GLN264

site_id	AC7
Number of Residues	4
Details	binding site for residue 4LE E 401

Chain	Residue
A	THR237
C	THR237
D	THR237
E	THR237

site_id	AC8
Number of Residues	6
Details	binding site for residue 4LE F 401

Chain	Residue
F	THR237
F	LEU240
G	THR237
H	THR237
I	THR237
J	THR237

site_id	AC9
Number of Residues	5
Details	binding site for residue 4LE F 402

Chain	Residue
F	LEU240
G	LEU240
G	ALA244
H	ALA244
J	ALA244

site_id	AD1
Number of Residues	3
Details	binding site for residue MES F 403

Chain	Residue
F	TRP206
G	THR259
G	GLN264

site_id	AD2
Number of Residues	4
Details	binding site for residue MES G 401

Chain	Residue
G	SER202
G	TRP206
G	HOH506
H	GLN264

site_id	AD3
Number of Residues	3
Details	binding site for residue MES H 401

Chain	Residue
H	TRP206
I	THR259
I	GLN264

site_id	AD4
Number of Residues	2
Details	binding site for residue MES I 401

Chain	Residue
I	TRP206
J	THR259

site_id	AD5
Number of Residues	3
Details	binding site for residue MES J 401

Chain	Residue
F	THR259
J	TRP206
J	HOH502

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)