4Z4D
Human Argonaute2 Bound to t1-G Target RNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000340 | molecular_function | RNA 7-methylguanosine cap binding |
| A | 0000932 | cellular_component | P-body |
| A | 0000993 | molecular_function | RNA polymerase II complex binding |
| A | 0001046 | molecular_function | core promoter sequence-specific DNA binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003725 | molecular_function | double-stranded RNA binding |
| A | 0003727 | molecular_function | single-stranded RNA binding |
| A | 0003729 | molecular_function | mRNA binding |
| A | 0003743 | molecular_function | translation initiation factor activity |
| A | 0004521 | molecular_function | RNA endonuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006412 | biological_process | translation |
| A | 0006413 | biological_process | translational initiation |
| A | 0016020 | cellular_component | membrane |
| A | 0016442 | cellular_component | RISC complex |
| A | 0016891 | molecular_function | RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism |
| A | 0030425 | cellular_component | dendrite |
| A | 0031047 | biological_process | regulatory ncRNA-mediated gene silencing |
| A | 0031054 | biological_process | pre-miRNA processing |
| A | 0033962 | biological_process | P-body assembly |
| A | 0035194 | biological_process | regulatory ncRNA-mediated post-transcriptional gene silencing |
| A | 0035196 | biological_process | miRNA processing |
| A | 0035197 | molecular_function | siRNA binding |
| A | 0035198 | molecular_function | miRNA binding |
| A | 0035278 | biological_process | miRNA-mediated gene silencing by inhibition of translation |
| A | 0035279 | biological_process | miRNA-mediated gene silencing by mRNA destabilization |
| A | 0035925 | molecular_function | mRNA 3'-UTR AU-rich region binding |
| A | 0036464 | cellular_component | cytoplasmic ribonucleoprotein granule |
| A | 0042985 | biological_process | negative regulation of amyloid precursor protein biosynthetic process |
| A | 0045727 | biological_process | positive regulation of translation |
| A | 0045766 | biological_process | positive regulation of angiogenesis |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0045947 | biological_process | negative regulation of translational initiation |
| A | 0060213 | biological_process | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070551 | molecular_function | endoribonuclease activity, cleaving siRNA-paired mRNA |
| A | 0070578 | cellular_component | RISC-loading complex |
| A | 0070922 | biological_process | RISC complex assembly |
| A | 0090128 | biological_process | regulation of synapse maturation |
| A | 0090624 | molecular_function | endoribonuclease activity, cleaving miRNA-paired mRNA |
| A | 0090625 | biological_process | siRNA-mediated gene silencing by mRNA destabilization |
| A | 0098794 | cellular_component | postsynapse |
| A | 0098808 | molecular_function | mRNA cap binding |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 1900153 | biological_process | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| A | 1901165 | biological_process | positive regulation of trophoblast cell migration |
| A | 1990904 | cellular_component | ribonucleoprotein complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 901 |
| Chain | Residue |
| A | ASP597 |
| A | VAL598 |
| A | HOH1017 |
| A | HOH1118 |
| A | HOH1286 |
| B | HOH227 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue IPH A 902 |
| Chain | Residue |
| A | TYR698 |
| A | GLN699 |
| A | PRO700 |
| A | ASP771 |
| A | HOH1110 |
| A | ARG688 |
| A | CYS691 |
| A | ILE692 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue IPH A 903 |
| Chain | Residue |
| A | LEU650 |
| A | TYR654 |
| A | LYS660 |
| A | TYR698 |
| A | HOH1157 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue IPH A 904 |
| Chain | Residue |
| A | PHE587 |
| A | GLN589 |
| A | PRO590 |
| A | VAL591 |
| A | ALA620 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue IPH A 905 |
| Chain | Residue |
| A | GLY541 |
| A | MET542 |
| A | ALA543 |
| A | LYS570 |
| A | THR852 |
| A | THR855 |
| A | TYR857 |
| A | HOH1229 |
| A | HOH1293 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue IPA A 906 |
| Chain | Residue |
| A | ALA184 |
| A | GLU197 |
| A | ALA227 |
| A | TYR654 |
| A | ARG658 |
| A | HOH1457 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue IPA A 907 |
| Chain | Residue |
| A | THR183 |
| A | PHE200 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue IPA A 908 |
| Chain | Residue |
| A | THR37 |
| A | ALA530 |
| A | ARG534 |
| A | VAL818 |
| A | LYS820 |
| A | HOH1211 |
| A | HOH1410 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 101 |
| Chain | Residue |
| B | A13 |
| B | HOH218 |
| B | HOH219 |
| B | HOH220 |
| B | HOH222 |
| B | HOH239 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue IPA B 102 |
| Chain | Residue |
| A | LYS525 |
| B | U1 |
| D | A2 |
| D | A3 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue IPA B 103 |
| Chain | Residue |
| A | THR599 |
| A | HIS600 |
| A | PRO601 |
| A | PRO602 |
| B | G9 |
| B | C10 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 101 |
| Chain | Residue |
| D | U4 |
| D | HOH209 |
| D | HOH219 |
| D | HOH227 |
| D | HOH229 |
| D | HOH235 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 301 |
| Details | Domain: {"description":"Piwi","evidences":[{"source":"HAMAP-Rule","id":"MF_03031","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 78 |
| Details | Region: {"description":"Interaction with guide RNA"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 13 |
| Details | Region: {"description":"Interaction with GW182 family members","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23603119","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"4-hydroxyproline","evidences":[{"source":"HAMAP-Rule","id":"MF_03031","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18690212","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
