4Z44

F454K Mutant of Tryptophan 7-halogenase PrnA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004497	molecular_function	monooxygenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0017000	biological_process	antibiotic biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	32
Details	binding site for residue FAD A 601

Chain	Residue
A	GLY12
A	GLU49
A	ALA50
A	GLU186
A	VAL187
A	CYS217
A	SER218
A	GLY219
A	LEU223
A	GLY336
A	LEU337
A	GLY13
A	PRO344
A	GLY349
A	ILE350
A	CL602
A	HOH721
A	HOH723
A	HOH726
A	HOH728
A	HOH767
A	HOH796
A	GLY14
A	HOH806
A	HOH815
A	HOH847
A	THR15
A	ALA16
A	SER39
A	ILE42
A	ARG44
A	ILE45

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CL A 602

Chain	Residue
A	PRO344
A	SER347
A	THR348
A	GLY349
A	FAD601
A	HOH841

---

site_id	AC3
Number of Residues	8
Details	binding site for residue PO4 A 603

Chain	Residue
A	PHE103
A	GLY104
A	TYR444
A	ASN459
A	HOH718
A	HOH724
A	HOH775
A	HOH845

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 604

Chain	Residue
A	ASN86
A	ASP92
A	PRO93
A	ARG95
A	LYS318

---

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 A 605

Chain	Residue
A	PRO43
A	ARG44
A	HIS165

---

site_id	AC6
Number of Residues	2
Details	binding site for residue SO4 A 606

Chain	Residue
A	ARG26
A	ARG178

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18979475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2APG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AQJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AR8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JKC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2APG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AR8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2APG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AQJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AR8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AR8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AQJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18979475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AQJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JKC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"Role in guiding and activating HOCl"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Site: {"description":"Important for activity","evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18979475","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---