4Z44
F454K Mutant of Tryptophan 7-halogenase PrnA
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | binding site for residue FAD A 601 |
| Chain | Residue |
| A | GLY12 |
| A | GLU49 |
| A | ALA50 |
| A | GLU186 |
| A | VAL187 |
| A | CYS217 |
| A | SER218 |
| A | GLY219 |
| A | LEU223 |
| A | GLY336 |
| A | LEU337 |
| A | GLY13 |
| A | PRO344 |
| A | GLY349 |
| A | ILE350 |
| A | CL602 |
| A | HOH721 |
| A | HOH723 |
| A | HOH726 |
| A | HOH728 |
| A | HOH767 |
| A | HOH796 |
| A | GLY14 |
| A | HOH806 |
| A | HOH815 |
| A | HOH847 |
| A | THR15 |
| A | ALA16 |
| A | SER39 |
| A | ILE42 |
| A | ARG44 |
| A | ILE45 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CL A 602 |
| Chain | Residue |
| A | PRO344 |
| A | SER347 |
| A | THR348 |
| A | GLY349 |
| A | FAD601 |
| A | HOH841 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 A 603 |
| Chain | Residue |
| A | PHE103 |
| A | GLY104 |
| A | TYR444 |
| A | ASN459 |
| A | HOH718 |
| A | HOH724 |
| A | HOH775 |
| A | HOH845 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 604 |
| Chain | Residue |
| A | ASN86 |
| A | ASP92 |
| A | PRO93 |
| A | ARG95 |
| A | LYS318 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 605 |
| Chain | Residue |
| A | PRO43 |
| A | ARG44 |
| A | HIS165 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 606 |
| Chain | Residue |
| A | ARG26 |
| A | ARG178 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:16195462 |
| Chain | Residue | Details |
| A | LYS79 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16195462, ECO:0000269|PubMed:18979475, ECO:0007744|PDB:2APG, ECO:0007744|PDB:2AQJ, ECO:0007744|PDB:2AR8, ECO:0007744|PDB:2JKC |
| Chain | Residue | Details |
| A | GLY13 | |
| A | SER39 | |
| A | ILE42 | |
| A | ILE45 | |
| A | ALA50 | |
| A | VAL187 | |
| A | LEU337 | |
| A | ILE350 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16195462, ECO:0007744|PDB:2APG, ECO:0007744|PDB:2AR8 |
| Chain | Residue | Details |
| A | THR15 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16195462, ECO:0007744|PDB:2APG, ECO:0007744|PDB:2AQJ, ECO:0007744|PDB:2AR8 |
| Chain | Residue | Details |
| A | ALA16 | |
| A | GLU49 | |
| A | THR348 | |
| A | GLY349 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16195462, ECO:0007744|PDB:2AR8 |
| Chain | Residue | Details |
| A | LYS79 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16195462, ECO:0007744|PDB:2AQJ |
| Chain | Residue | Details |
| A | GLU346 | |
| A | GLU450 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16195462, ECO:0000269|PubMed:18979475, ECO:0007744|PDB:2AQJ, ECO:0007744|PDB:2JKC |
| Chain | Residue | Details |
| A | TYR443 | |
| A | TYR444 | |
| A | LYS454 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | SITE: Role in guiding and activating HOCl |
| Chain | Residue | Details |
| A | LYS79 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | SITE: Important for activity => ECO:0000305|PubMed:16195462, ECO:0000305|PubMed:18979475 |
| Chain | Residue | Details |
| A | GLU346 |
