4Z2M
Crystal structure of human SPT16 Mid-AID/H3-H4 tetramer FACT Histone complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0035101 | cellular_component | FACT complex |
| G | 0000786 | cellular_component | nucleosome |
| G | 0003677 | molecular_function | DNA binding |
| G | 0030527 | molecular_function | structural constituent of chromatin |
| G | 0046982 | molecular_function | protein heterodimerization activity |
| H | 0000781 | cellular_component | chromosome, telomeric region |
| H | 0000786 | cellular_component | nucleosome |
| H | 0003677 | molecular_function | DNA binding |
| H | 0003723 | molecular_function | RNA binding |
| H | 0005515 | molecular_function | protein binding |
| H | 0005576 | cellular_component | extracellular region |
| H | 0005634 | cellular_component | nucleus |
| H | 0005654 | cellular_component | nucleoplasm |
| H | 0005694 | cellular_component | chromosome |
| H | 0006325 | biological_process | chromatin organization |
| H | 0006334 | biological_process | nucleosome assembly |
| H | 0016020 | cellular_component | membrane |
| H | 0030527 | molecular_function | structural constituent of chromatin |
| H | 0032200 | biological_process | telomere organization |
| H | 0032991 | cellular_component | protein-containing complex |
| H | 0043505 | cellular_component | CENP-A containing nucleosome |
| H | 0045653 | biological_process | negative regulation of megakaryocyte differentiation |
| H | 0046982 | molecular_function | protein heterodimerization activity |
| H | 0061644 | biological_process | protein localization to CENP-A containing chromatin |
| H | 0070062 | cellular_component | extracellular exosome |
| I | 0000786 | cellular_component | nucleosome |
| I | 0003677 | molecular_function | DNA binding |
| I | 0030527 | molecular_function | structural constituent of chromatin |
| I | 0046982 | molecular_function | protein heterodimerization activity |
| J | 0000781 | cellular_component | chromosome, telomeric region |
| J | 0000786 | cellular_component | nucleosome |
| J | 0003677 | molecular_function | DNA binding |
| J | 0003723 | molecular_function | RNA binding |
| J | 0005515 | molecular_function | protein binding |
| J | 0005576 | cellular_component | extracellular region |
| J | 0005634 | cellular_component | nucleus |
| J | 0005654 | cellular_component | nucleoplasm |
| J | 0005694 | cellular_component | chromosome |
| J | 0006325 | biological_process | chromatin organization |
| J | 0006334 | biological_process | nucleosome assembly |
| J | 0016020 | cellular_component | membrane |
| J | 0030527 | molecular_function | structural constituent of chromatin |
| J | 0032200 | biological_process | telomere organization |
| J | 0032991 | cellular_component | protein-containing complex |
| J | 0043505 | cellular_component | CENP-A containing nucleosome |
| J | 0045653 | biological_process | negative regulation of megakaryocyte differentiation |
| J | 0046982 | molecular_function | protein heterodimerization activity |
| J | 0061644 | biological_process | protein localization to CENP-A containing chromatin |
| J | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | DNA_BIND: |
| Chain | Residue | Details |
| H | LYS16-LYS20 | |
| J | LYS16-LYS20 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:17967882 |
| Chain | Residue | Details |
| H | SER1 | |
| J | SER1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate => ECO:0000250|UniProtKB:P62806 |
| Chain | Residue | Details |
| H | ARG3 | |
| J | ARG3 | |
| B | LYS904 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-lactoyllysine; alternate => ECO:0000269|PubMed:31645732 |
| Chain | Residue | Details |
| H | LYS5 | |
| J | LYS5 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-propionyllysine; alternate => ECO:0000269|PubMed:17267393 |
| Chain | Residue | Details |
| H | LYS8 | |
| H | LYS16 | |
| H | LYS44 | |
| J | LYS8 | |
| J | LYS16 | |
| J | LYS44 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435 |
| Chain | Residue | Details |
| H | LYS12 | |
| H | LYS31 | |
| H | LYS77 | |
| H | LYS91 | |
| J | LYS12 | |
| J | LYS31 | |
| J | LYS77 | |
| J | LYS91 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:15964846, ECO:0000269|PubMed:17967882, ECO:0000269|PubMed:27338793 |
| Chain | Residue | Details |
| H | LYS20 | |
| J | LYS20 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PAK2 => ECO:0000269|PubMed:21724829, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| H | SER47 | |
| J | SER47 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| H | TYR51 | |
| J | TYR51 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297 |
| Chain | Residue | Details |
| H | LYS59 | |
| J | LYS59 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62806 |
| Chain | Residue | Details |
| H | LYS79 | |
| J | LYS79 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62806 |
| Chain | Residue | Details |
| H | THR80 | |
| J | THR80 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| H | TYR88 | |
| J | TYR88 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447 |
| Chain | Residue | Details |
| H | LYS12 | |
| J | LYS12 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:19818714 |
| Chain | Residue | Details |
| H | LYS91 | |
| J | LYS91 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| H | LYS20 | |
| H | LYS59 | |
| H | LYS79 | |
| J | LYS20 | |
| J | LYS59 | |
| J | LYS79 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000269|PubMed:30886146 |
| Chain | Residue | Details |
| H | LYS31 | |
| J | LYS31 |
