4Z2E

Quinolone(Trovafloxacin)-DNA cleavage complex of gyrase from S. pneumoniae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006259	biological_process	DNA metabolic process
A	0006265	biological_process	DNA topological change
B	0003677	molecular_function	DNA binding
B	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0006259	biological_process	DNA metabolic process
B	0006265	biological_process	DNA topological change
C	0003677	molecular_function	DNA binding
C	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
C	0005524	molecular_function	ATP binding
C	0006265	biological_process	DNA topological change
D	0003677	molecular_function	DNA binding
D	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
D	0005524	molecular_function	ATP binding
D	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue TR6 F 101

Chain	Residue
B	SER81
H	DA5
C	GLY434
C	ARG456
C	GLY457
C	GLU475
F	DG1
F	MG102
G	DT15
H	DC4

---

site_id	AC2
Number of Residues	1
Details	binding site for residue MG F 102

Chain	Residue
F	TR6101

---

site_id	AC3
Number of Residues	8
Details	binding site for residue TR6 H 101

Chain	Residue
A	SER81
D	ARG456
D	GLY457
E	DT15
F	DC4
F	DA5
H	DG1
H	MG102

---

site_id	AC4
Number of Residues	1
Details	binding site for residue MG H 102

Chain	Residue
H	TR6101

---

Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. IVEGDSAGG

Chain	Residue	Details
C	ILE431-GLY439

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01898

Chain	Residue	Details
C	GLU433
C	ASP506
C	ASP508
D	GLU433
D	ASP506
D	ASP508

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898

Chain	Residue	Details
C	LYS458
C	ASN461
D	LYS458
D	ASN461

---