4Z1M
Bovine F1-ATPase inhibited by three copies of the inhibitor protein IF1 crystallised in the presence of thiophosphate.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005743 | cellular_component | mitochondrial inner membrane |
A | 0005754 | cellular_component | mitochondrial proton-transporting ATP synthase, catalytic core |
A | 0005886 | cellular_component | plasma membrane |
A | 0006754 | biological_process | ATP biosynthetic process |
A | 0015986 | biological_process | proton motive force-driven ATP synthesis |
A | 0032559 | molecular_function | adenyl ribonucleotide binding |
A | 0043531 | molecular_function | ADP binding |
A | 0045259 | cellular_component | proton-transporting ATP synthase complex |
A | 0045261 | cellular_component | proton-transporting ATP synthase complex, catalytic core F(1) |
A | 0046034 | biological_process | ATP metabolic process |
A | 0046933 | molecular_function | proton-transporting ATP synthase activity, rotational mechanism |
A | 1902600 | biological_process | proton transmembrane transport |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005743 | cellular_component | mitochondrial inner membrane |
B | 0005754 | cellular_component | mitochondrial proton-transporting ATP synthase, catalytic core |
B | 0005886 | cellular_component | plasma membrane |
B | 0006754 | biological_process | ATP biosynthetic process |
B | 0015986 | biological_process | proton motive force-driven ATP synthesis |
B | 0032559 | molecular_function | adenyl ribonucleotide binding |
B | 0043531 | molecular_function | ADP binding |
B | 0045259 | cellular_component | proton-transporting ATP synthase complex |
B | 0045261 | cellular_component | proton-transporting ATP synthase complex, catalytic core F(1) |
B | 0046034 | biological_process | ATP metabolic process |
B | 0046933 | molecular_function | proton-transporting ATP synthase activity, rotational mechanism |
B | 1902600 | biological_process | proton transmembrane transport |
C | 0005515 | molecular_function | protein binding |
C | 0005524 | molecular_function | ATP binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005739 | cellular_component | mitochondrion |
C | 0005743 | cellular_component | mitochondrial inner membrane |
C | 0005754 | cellular_component | mitochondrial proton-transporting ATP synthase, catalytic core |
C | 0005886 | cellular_component | plasma membrane |
C | 0006754 | biological_process | ATP biosynthetic process |
C | 0015986 | biological_process | proton motive force-driven ATP synthesis |
C | 0032559 | molecular_function | adenyl ribonucleotide binding |
C | 0043531 | molecular_function | ADP binding |
C | 0045259 | cellular_component | proton-transporting ATP synthase complex |
C | 0045261 | cellular_component | proton-transporting ATP synthase complex, catalytic core F(1) |
C | 0046034 | biological_process | ATP metabolic process |
C | 0046933 | molecular_function | proton-transporting ATP synthase activity, rotational mechanism |
C | 1902600 | biological_process | proton transmembrane transport |
D | 0005515 | molecular_function | protein binding |
D | 0005524 | molecular_function | ATP binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0005739 | cellular_component | mitochondrion |
D | 0005743 | cellular_component | mitochondrial inner membrane |
D | 0005753 | cellular_component | mitochondrial proton-transporting ATP synthase complex |
D | 0006754 | biological_process | ATP biosynthetic process |
D | 0015986 | biological_process | proton motive force-driven ATP synthesis |
D | 0016887 | molecular_function | ATP hydrolysis activity |
D | 0042776 | biological_process | proton motive force-driven mitochondrial ATP synthesis |
D | 0045259 | cellular_component | proton-transporting ATP synthase complex |
D | 0045261 | cellular_component | proton-transporting ATP synthase complex, catalytic core F(1) |
D | 0046034 | biological_process | ATP metabolic process |
D | 0046933 | molecular_function | proton-transporting ATP synthase activity, rotational mechanism |
D | 0046961 | molecular_function | proton-transporting ATPase activity, rotational mechanism |
D | 1902600 | biological_process | proton transmembrane transport |
E | 0005515 | molecular_function | protein binding |
E | 0005524 | molecular_function | ATP binding |
E | 0005737 | cellular_component | cytoplasm |
E | 0005739 | cellular_component | mitochondrion |
E | 0005743 | cellular_component | mitochondrial inner membrane |
E | 0005753 | cellular_component | mitochondrial proton-transporting ATP synthase complex |
E | 0006754 | biological_process | ATP biosynthetic process |
E | 0015986 | biological_process | proton motive force-driven ATP synthesis |
E | 0016887 | molecular_function | ATP hydrolysis activity |
E | 0042776 | biological_process | proton motive force-driven mitochondrial ATP synthesis |
E | 0045259 | cellular_component | proton-transporting ATP synthase complex |
E | 0045261 | cellular_component | proton-transporting ATP synthase complex, catalytic core F(1) |
E | 0046034 | biological_process | ATP metabolic process |
E | 0046933 | molecular_function | proton-transporting ATP synthase activity, rotational mechanism |
E | 0046961 | molecular_function | proton-transporting ATPase activity, rotational mechanism |
E | 1902600 | biological_process | proton transmembrane transport |
F | 0005515 | molecular_function | protein binding |
F | 0005524 | molecular_function | ATP binding |
F | 0005737 | cellular_component | cytoplasm |
F | 0005739 | cellular_component | mitochondrion |
F | 0005743 | cellular_component | mitochondrial inner membrane |
F | 0005753 | cellular_component | mitochondrial proton-transporting ATP synthase complex |
F | 0006754 | biological_process | ATP biosynthetic process |
F | 0015986 | biological_process | proton motive force-driven ATP synthesis |
F | 0016887 | molecular_function | ATP hydrolysis activity |
F | 0042776 | biological_process | proton motive force-driven mitochondrial ATP synthesis |
F | 0045259 | cellular_component | proton-transporting ATP synthase complex |
F | 0045261 | cellular_component | proton-transporting ATP synthase complex, catalytic core F(1) |
F | 0046034 | biological_process | ATP metabolic process |
F | 0046933 | molecular_function | proton-transporting ATP synthase activity, rotational mechanism |
F | 0046961 | molecular_function | proton-transporting ATPase activity, rotational mechanism |
F | 1902600 | biological_process | proton transmembrane transport |
G | 0000275 | cellular_component | mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) |
G | 0005515 | molecular_function | protein binding |
G | 0005739 | cellular_component | mitochondrion |
G | 0005743 | cellular_component | mitochondrial inner membrane |
G | 0006754 | biological_process | ATP biosynthetic process |
G | 0015986 | biological_process | proton motive force-driven ATP synthesis |
G | 0045259 | cellular_component | proton-transporting ATP synthase complex |
G | 0045261 | cellular_component | proton-transporting ATP synthase complex, catalytic core F(1) |
G | 0046933 | molecular_function | proton-transporting ATP synthase activity, rotational mechanism |
G | 1902600 | biological_process | proton transmembrane transport |
H | 0005739 | cellular_component | mitochondrion |
H | 0032780 | biological_process | negative regulation of ATP-dependent activity |
H | 0042030 | molecular_function | ATPase inhibitor activity |
I | 0005739 | cellular_component | mitochondrion |
I | 0032780 | biological_process | negative regulation of ATP-dependent activity |
I | 0042030 | molecular_function | ATPase inhibitor activity |
J | 0005739 | cellular_component | mitochondrion |
J | 0032780 | biological_process | negative regulation of ATP-dependent activity |
J | 0042030 | molecular_function | ATPase inhibitor activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | binding site for residue ATP A 601 |
Chain | Residue |
A | ASP170 |
A | PHE357 |
A | ARG362 |
A | PRO363 |
A | GLN430 |
A | GLN432 |
A | MG602 |
A | HOH702 |
A | HOH703 |
A | HOH704 |
A | ARG171 |
A | GLN172 |
A | THR173 |
A | GLY174 |
A | LYS175 |
A | THR176 |
A | SER177 |
A | GLU328 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue MG A 602 |
Chain | Residue |
A | THR176 |
A | ATP601 |
A | HOH702 |
A | HOH703 |
A | HOH704 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue GOL A 603 |
Chain | Residue |
A | GLU50 |
A | MET62 |
A | VAL129 |
A | GLY130 |
A | TYR244 |
A | LEU245 |
A | TYR248 |
A | ARG304 |
site_id | AC4 |
Number of Residues | 16 |
Details | binding site for residue ATP B 601 |
Chain | Residue |
B | GLN172 |
B | THR173 |
B | GLY174 |
B | LYS175 |
B | THR176 |
B | SER177 |
B | PHE357 |
B | ARG362 |
B | GLN430 |
B | GLN432 |
B | MG602 |
B | HOH701 |
B | HOH702 |
B | HOH703 |
E | ARG356 |
E | ASP359 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue MG B 602 |
Chain | Residue |
B | THR176 |
B | ATP601 |
B | HOH701 |
B | HOH702 |
B | HOH703 |
site_id | AC6 |
Number of Residues | 1 |
Details | binding site for residue CL B 603 |
Chain | Residue |
B | ALA114 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue GOL B 604 |
Chain | Residue |
B | GLY130 |
B | TYR244 |
B | TYR248 |
B | ARG304 |
site_id | AC8 |
Number of Residues | 17 |
Details | binding site for residue ATP C 601 |
Chain | Residue |
C | GLN172 |
C | THR173 |
C | GLY174 |
C | LYS175 |
C | THR176 |
C | SER177 |
C | PHE357 |
C | ARG362 |
C | GLN430 |
C | GLN432 |
C | MG602 |
C | HOH704 |
C | HOH705 |
F | ARG356 |
F | MET358 |
F | ASP359 |
F | TYR368 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue MG C 602 |
Chain | Residue |
C | THR176 |
C | ATP601 |
C | HOH703 |
C | HOH704 |
C | HOH705 |
site_id | AD1 |
Number of Residues | 2 |
Details | binding site for residue CL C 603 |
Chain | Residue |
C | SER123 |
C | ARG126 |
site_id | AD2 |
Number of Residues | 2 |
Details | binding site for residue CL C 604 |
Chain | Residue |
C | TYR248 |
C | ARG304 |
site_id | AD3 |
Number of Residues | 16 |
Details | binding site for residue ADP D 600 |
Chain | Residue |
C | ARG373 |
D | GLY157 |
D | GLY159 |
D | VAL160 |
D | GLY161 |
D | LYS162 |
D | THR163 |
D | VAL164 |
D | TYR345 |
D | PHE418 |
D | PHE424 |
D | THR425 |
D | MG601 |
D | HOH702 |
D | HOH703 |
D | HOH705 |
site_id | AD4 |
Number of Residues | 6 |
Details | binding site for residue MG D 601 |
Chain | Residue |
D | THR163 |
D | ADP600 |
D | HOH702 |
D | HOH703 |
D | HOH704 |
D | HOH705 |
site_id | AD5 |
Number of Residues | 1 |
Details | binding site for residue CL E 501 |
Chain | Residue |
E | ASP330 |
site_id | AD6 |
Number of Residues | 1 |
Details | binding site for residue CL E 502 |
Chain | Residue |
E | ASN223 |
site_id | AD7 |
Number of Residues | 3 |
Details | binding site for residue CL E 503 |
Chain | Residue |
E | GLU241 |
E | ARG244 |
E | ASP245 |
site_id | AD8 |
Number of Residues | 2 |
Details | binding site for residue CL E 504 |
Chain | Residue |
E | GLN112 |
E | TYR242 |
site_id | AD9 |
Number of Residues | 15 |
Details | binding site for residue ADP F 501 |
Chain | Residue |
B | ARG373 |
F | GLY157 |
F | GLY159 |
F | VAL160 |
F | GLY161 |
F | LYS162 |
F | THR163 |
F | VAL164 |
F | TYR345 |
F | PHE418 |
F | PHE424 |
F | MG502 |
F | HOH601 |
F | HOH602 |
F | HOH604 |
site_id | AE1 |
Number of Residues | 6 |
Details | binding site for residue MG F 502 |
Chain | Residue |
F | THR163 |
F | ADP501 |
F | HOH601 |
F | HOH602 |
F | HOH603 |
F | HOH604 |
site_id | AE2 |
Number of Residues | 1 |
Details | binding site for residue CL F 503 |
Chain | Residue |
F | ASP288 |
site_id | AE3 |
Number of Residues | 2 |
Details | binding site for residue CL F 504 |
Chain | Residue |
F | ASN223 |
F | GLU224 |
site_id | AE4 |
Number of Residues | 1 |
Details | binding site for residue CL G 301 |
Chain | Residue |
G | LYS260 |
site_id | AE5 |
Number of Residues | 3 |
Details | binding site for residue CL G 302 |
Chain | Residue |
C | GLY290 |
D | PRO276 |
D | GLY280 |
Functional Information from PROSITE/UniProt
site_id | PS00152 |
Number of Residues | 10 |
Details | ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAINVGLSVS |
Chain | Residue | Details |
A | PRO363-SER372 | |
D | PRO346-SER355 |
site_id | PS00153 |
Number of Residues | 14 |
Details | ATPASE_GAMMA ATP synthase gamma subunit signature. ITkEliEiisGAaA |
Chain | Residue | Details |
G | ILE258-ALA271 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | SITE: Participates in pH sensing |
Chain | Residue | Details |
H | GLU26 | |
H | HIS49 | |
I | GLU26 | |
I | HIS49 | |
J | GLU26 | |
J | HIS49 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q91VR2 |
Chain | Residue | Details |
G | LYS24 | |
G | LYS245 | |
F | ARG189 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P36542 |
Chain | Residue | Details |
G | LYS30 | |
E | LYS472 | |
F | LYS74 | |
F | LYS111 | |
F | LYS209 | |
F | LYS214 | |
F | LYS472 | |
G | LYS172 | |
D | LYS209 | |
D | LYS214 | |
D | LYS472 | |
E | LYS74 | |
E | LYS111 | |
E | LYS209 | |
E | LYS214 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q91VR2 |
Chain | Residue | Details |
G | LYS90 | |
C | SER22 | |
C | SER123 | |
C | SER141 | |
G | LYS129 | |
E | LYS148 | |
E | LYS376 | |
F | LYS148 | |
F | LYS376 | |
B | SER123 | |
B | SER141 | |
C | SER10 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P36542 |
Chain | Residue | Details |
G | SER121 | |
E | THR262 | |
F | THR262 |
site_id | SWS_FT_FI6 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06576 |
Chain | Residue | Details |
D | SER365 | |
E | SER365 | |
F | SER365 |
site_id | SWS_FT_FI7 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P10719 |
Chain | Residue | Details |
D | SER383 | |
B | LYS498 | |
C | LYS80 | |
C | LYS83 | |
C | LYS89 | |
C | LYS197 | |
C | LYS498 | |
E | SER383 | |
F | SER383 | |
A | LYS197 | |
A | LYS498 | |
B | LYS80 | |
B | LYS83 | |
B | LYS89 | |
B | LYS197 |
site_id | SWS_FT_FI8 |
Number of Residues | 6 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P56480 |
Chain | Residue | Details |
D | LYS430 | |
D | LYS435 | |
E | LYS430 | |
E | LYS435 | |
F | LYS430 | |
F | LYS435 |
site_id | SWS_FT_FI9 |
Number of Residues | 3 |
Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250 |
Chain | Residue | Details |
D | SER56 | |
A | LYS488 | |
A | LYS496 | |
B | LYS118 | |
B | LYS124 | |
B | LYS187 | |
B | LYS196 | |
B | LYS218 | |
B | LYS262 | |
B | LYS384 | |
B | LYS455 | |
E | SER56 | |
B | LYS463 | |
B | LYS488 | |
B | LYS496 | |
C | LYS118 | |
C | LYS124 | |
C | LYS187 | |
C | LYS196 | |
C | LYS218 | |
C | LYS262 | |
C | LYS384 | |
F | SER56 | |
C | LYS455 | |
C | LYS463 | |
C | LYS488 | |
C | LYS496 | |
A | LYS196 | |
A | LYS218 | |
A | LYS262 | |
A | LYS384 | |
A | LYS455 | |
A | LYS463 |
site_id | SWS_FT_FI10 |
Number of Residues | 3 |
Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q03265 |
Chain | Residue | Details |
A | ARG161 | |
B | ARG161 | |
C | ARG161 |
site_id | SWS_FT_FI11 |
Number of Residues | 3 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P25705 |
Chain | Residue | Details |
A | LYS391 | |
B | LYS391 | |
C | LYS391 |
site_id | SWS_FT_FI12 |
Number of Residues | 3 |
Details | CARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000250 |
Chain | Residue | Details |
A | SER33 | |
B | SER33 | |
C | SER33 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 178 |
Chain | Residue | Details |
D | LYS162 | electrostatic stabiliser |
D | GLU188 | electrostatic stabiliser |
D | ARG189 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 3 |
Details | M-CSA 178 |
Chain | Residue | Details |
E | LYS162 | electrostatic stabiliser |
E | GLU188 | electrostatic stabiliser |
E | ARG189 | electrostatic stabiliser |
site_id | MCSA3 |
Number of Residues | 3 |
Details | M-CSA 178 |
Chain | Residue | Details |
F | LYS162 | electrostatic stabiliser |
F | GLU188 | electrostatic stabiliser |
F | ARG189 | electrostatic stabiliser |