4Z0J
F96S/S73A Double mutant of Plasmodium Falciparum Triosephosphate Isomerase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004807 | molecular_function | triose-phosphate isomerase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019563 | biological_process | glycerol catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| B | 0004807 | molecular_function | triose-phosphate isomerase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0019563 | biological_process | glycerol catabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 301 |
| Chain | Residue |
| A | SER45 |
| A | VAL46 |
| A | TYR48 |
| A | ASP49 |
| A | LEU86 |
| A | HOH484 |
| B | VAL46 |
| B | HOH404 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | ASN120 |
| A | ASN159 |
| A | HOH412 |
| A | LEU117 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 303 |
| Chain | Residue |
| A | CYS196 |
| A | GLY197 |
| A | HOH404 |
| A | HOH433 |
| B | ARG52 |
| B | LYS53 |
| B | LEU55 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | ASN71 |
| A | GLU81 |
| A | HOH420 |
| B | GLY15 |
| B | THR16 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 305 |
| Chain | Residue |
| A | ASN65 |
| A | ARG98 |
| A | GLU104 |
| A | LYS112 |
| A | HOH466 |
| A | HOH507 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 306 |
| Chain | Residue |
| A | SER211 |
| A | GLY232 |
| A | ASN233 |
| A | HOH424 |
| A | HOH432 |
| A | HOH446 |
| A | HOH451 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 301 |
| Chain | Residue |
| B | ASN137 |
| B | ILE140 |
| B | EDO303 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 302 |
| Chain | Residue |
| A | HIS50 |
| B | ASP49 |
| B | HOH448 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 303 |
| Chain | Residue |
| B | ASN137 |
| B | LYS138 |
| B | ILE140 |
| B | GLU141 |
| B | EDO301 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 304 |
| Chain | Residue |
| B | SER19 |
| B | SER22 |
| B | LEU23 |
| B | GLU238 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 305 |
| Chain | Residue |
| B | LYS186 |
| B | LYS190 |
| B | HOH417 |
| B | HOH460 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 306 |
| Chain | Residue |
| B | LEU117 |
| B | ASN120 |
| B | LEU121 |
| B | ASP155 |
| B | ASN156 |
| B | ASN159 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 307 |
| Chain | Residue |
| A | LYS148 |
| A | HOH428 |
| B | SER60 |
| B | GLU89 |
| B | HOH429 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 308 |
| Chain | Residue |
| B | SER211 |
| B | GLY232 |
| B | ASN233 |
| B | HOH437 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 309 |
| Chain | Residue |
| B | ASN65 |
| B | ARG98 |
| B | GLU104 |
| B | LYS112 |
Functional Information from PROSITE/UniProt
| site_id | PS00171 |
| Number of Residues | 11 |
| Details | TIM_1 Triosephosphate isomerase active site. VYEPLWAIGTG |
| Chain | Residue | Details |
| A | VAL163-GLY173 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Electrophile => ECO:0000255|PROSITE-ProRule:PRU10127 |
| Chain | Residue | Details |
| A | HIS95 | |
| B | HIS95 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10127 |
| Chain | Residue | Details |
| A | GLU165 | |
| B | GLU165 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12454456, ECO:0000269|PubMed:14563846, ECO:0000269|PubMed:19622869, ECO:0007744|PDB:1M7O, ECO:0007744|PDB:1O5X, ECO:0007744|PDB:2VFI |
| Chain | Residue | Details |
| A | ASN10 | |
| B | ASN10 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12403619, ECO:0000269|PubMed:15465054, ECO:0000269|PubMed:19622869, ECO:0007744|PDB:1LYX, ECO:0007744|PDB:1LZO, ECO:0007744|PDB:1WOA, ECO:0007744|PDB:2VFI |
| Chain | Residue | Details |
| A | LYS12 | |
| B | LYS12 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12403619, ECO:0000269|PubMed:19622869, ECO:0007744|PDB:1LYX, ECO:0007744|PDB:2VFI |
| Chain | Residue | Details |
| A | GLY171 | |
| B | GLY171 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12454456, ECO:0000269|PubMed:14563846, ECO:0000269|PubMed:15465054, ECO:0000269|PubMed:19622869, ECO:0007744|PDB:1M7O, ECO:0007744|PDB:1O5X, ECO:0007744|PDB:1WOA, ECO:0007744|PDB:2VFI |
| Chain | Residue | Details |
| A | LEU230 | |
| B | LEU230 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12403619, ECO:0000269|PubMed:12454456, ECO:0000269|PubMed:14563846, ECO:0000269|PubMed:15465054, ECO:0000269|PubMed:19622869, ECO:0000312|PDB:1LZO, ECO:0007744|PDB:1LYX, ECO:0007744|PDB:1M7O, ECO:0007744|PDB:1M7P, ECO:0007744|PDB:1O5X, ECO:0007744|PDB:1WOA, ECO:0007744|PDB:2VFI |
| Chain | Residue | Details |
| A | GLY232 | |
| B | GLY232 |
