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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4YZF

Crystal structure of the anion exchanger domain of human erythrocyte Band 3

Functional Information from GO Data
ChainGOidnamespacecontents
A0005452molecular_functionsolute:inorganic anion antiporter activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006820biological_processmonoatomic anion transport
A0006821biological_processchloride transport
A0006873biological_processintracellular monoatomic ion homeostasis
A0007596biological_processblood coagulation
A0008092molecular_functioncytoskeletal protein binding
A0008509molecular_functionmonoatomic anion transmembrane transporter activity
A0009898cellular_componentcytoplasmic side of plasma membrane
A0015106molecular_functionbicarbonate transmembrane transporter activity
A0015108molecular_functionchloride transmembrane transporter activity
A0015297molecular_functionantiporter activity
A0015701biological_processbicarbonate transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0017121biological_processplasma membrane phospholipid scrambling
A0030018cellular_componentZ disc
A0030492molecular_functionhemoglobin binding
A0030506molecular_functionankyrin binding
A0030863cellular_componentcortical cytoskeleton
A0035811biological_processnegative regulation of urine volume
A0042803molecular_functionprotein homodimerization activity
A0043495molecular_functionmembrane-membrane adaptor activity
A0045852biological_processpH elevation
A0048821biological_processerythrocyte development
A0051453biological_processregulation of intracellular pH
A0055085biological_processtransmembrane transport
A0070062cellular_componentextracellular exosome
A0072562cellular_componentblood microparticle
A0072659biological_processprotein localization to plasma membrane
A0140900molecular_functionchloride:bicarbonate antiporter activity
A0170014cellular_componentankyrin-1 complex
A1902476biological_processchloride transmembrane transport
A1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
B0005452molecular_functionsolute:inorganic anion antiporter activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006820biological_processmonoatomic anion transport
B0006821biological_processchloride transport
B0006873biological_processintracellular monoatomic ion homeostasis
B0007596biological_processblood coagulation
B0008092molecular_functioncytoskeletal protein binding
B0008509molecular_functionmonoatomic anion transmembrane transporter activity
B0009898cellular_componentcytoplasmic side of plasma membrane
B0015106molecular_functionbicarbonate transmembrane transporter activity
B0015108molecular_functionchloride transmembrane transporter activity
B0015297molecular_functionantiporter activity
B0015701biological_processbicarbonate transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0017121biological_processplasma membrane phospholipid scrambling
B0030018cellular_componentZ disc
B0030492molecular_functionhemoglobin binding
B0030506molecular_functionankyrin binding
B0030863cellular_componentcortical cytoskeleton
B0035811biological_processnegative regulation of urine volume
B0042803molecular_functionprotein homodimerization activity
B0043495molecular_functionmembrane-membrane adaptor activity
B0045852biological_processpH elevation
B0048821biological_processerythrocyte development
B0051453biological_processregulation of intracellular pH
B0055085biological_processtransmembrane transport
B0070062cellular_componentextracellular exosome
B0072562cellular_componentblood microparticle
B0072659biological_processprotein localization to plasma membrane
B0140900molecular_functionchloride:bicarbonate antiporter activity
B0170014cellular_componentankyrin-1 complex
B1902476biological_processchloride transmembrane transport
B1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
C0005452molecular_functionsolute:inorganic anion antiporter activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006820biological_processmonoatomic anion transport
C0006821biological_processchloride transport
C0006873biological_processintracellular monoatomic ion homeostasis
C0007596biological_processblood coagulation
C0008092molecular_functioncytoskeletal protein binding
C0008509molecular_functionmonoatomic anion transmembrane transporter activity
C0009898cellular_componentcytoplasmic side of plasma membrane
C0015106molecular_functionbicarbonate transmembrane transporter activity
C0015108molecular_functionchloride transmembrane transporter activity
C0015297molecular_functionantiporter activity
C0015701biological_processbicarbonate transport
C0016020cellular_componentmembrane
C0016323cellular_componentbasolateral plasma membrane
C0017121biological_processplasma membrane phospholipid scrambling
C0030018cellular_componentZ disc
C0030492molecular_functionhemoglobin binding
C0030506molecular_functionankyrin binding
C0030863cellular_componentcortical cytoskeleton
C0035811biological_processnegative regulation of urine volume
C0042803molecular_functionprotein homodimerization activity
C0043495molecular_functionmembrane-membrane adaptor activity
C0045852biological_processpH elevation
C0048821biological_processerythrocyte development
C0051453biological_processregulation of intracellular pH
C0055085biological_processtransmembrane transport
C0070062cellular_componentextracellular exosome
C0072562cellular_componentblood microparticle
C0072659biological_processprotein localization to plasma membrane
C0140900molecular_functionchloride:bicarbonate antiporter activity
C0170014cellular_componentankyrin-1 complex
C1902476biological_processchloride transmembrane transport
C1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
D0005452molecular_functionsolute:inorganic anion antiporter activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006820biological_processmonoatomic anion transport
D0006821biological_processchloride transport
D0006873biological_processintracellular monoatomic ion homeostasis
D0007596biological_processblood coagulation
D0008092molecular_functioncytoskeletal protein binding
D0008509molecular_functionmonoatomic anion transmembrane transporter activity
D0009898cellular_componentcytoplasmic side of plasma membrane
D0015106molecular_functionbicarbonate transmembrane transporter activity
D0015108molecular_functionchloride transmembrane transporter activity
D0015297molecular_functionantiporter activity
D0015701biological_processbicarbonate transport
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0017121biological_processplasma membrane phospholipid scrambling
D0030018cellular_componentZ disc
D0030492molecular_functionhemoglobin binding
D0030506molecular_functionankyrin binding
D0030863cellular_componentcortical cytoskeleton
D0035811biological_processnegative regulation of urine volume
D0042803molecular_functionprotein homodimerization activity
D0043495molecular_functionmembrane-membrane adaptor activity
D0045852biological_processpH elevation
D0048821biological_processerythrocyte development
D0051453biological_processregulation of intracellular pH
D0055085biological_processtransmembrane transport
D0070062cellular_componentextracellular exosome
D0072562cellular_componentblood microparticle
D0072659biological_processprotein localization to plasma membrane
D0140900molecular_functionchloride:bicarbonate antiporter activity
D0170014cellular_componentankyrin-1 complex
D1902476biological_processchloride transmembrane transport
D1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue 4KU A 1000
ChainResidue
APRO419
APRO467
APHE532
AGLU535
ALYS539
AGLU681
ALYS851
site_idAC2
Number of Residues7
Detailsbinding site for residue 4KU B 1000
ChainResidue
BPHE532
BGLU535
BLYS539
BPHE792
BLYS851
BTHR422
BPRO467
site_idAC3
Number of Residues8
Detailsbinding site for residue 4KU C 1000
ChainResidue
CPRO419
CTHR422
CPRO467
CPHE532
CGLU535
CLYS539
CPHE792
CLYS851
site_idAC4
Number of Residues14
Detailsbinding site for Di-peptide 4KU D 1000 and LYS D 851
ChainResidue
DPRO419
DTHR422
DPRO467
DILE531
DPHE532
DGLU535
DLYS539
DLEU847
DVAL849
DVAL850
DSER852
DTHR853
DSER856
DLEU859
site_idAC5
Number of Residues14
Detailsbinding site for Di-peptide 4KU D 1000 and LYS D 539
ChainResidue
DPRO419
DTHR422
DPRO467
DPHE532
DGLU535
DTHR536
DPHE537
DSER538
DLEU540
DILE541
DLYS542
DILE543
DPHE789
DLYS851
Functional Information from PROSITE/UniProt
site_idPS00219
Number of Residues12
DetailsANION_EXCHANGER_1 Anion exchangers family signature 1. FGGLVRDIRRRY
ChainResidueDetails
APHE379-TYR390
site_idPS00220
Number of Residues15
DetailsANION_EXCHANGER_2 Anion exchangers family signature 2. FLISLIFIYETFsKL
ChainResidueDetails
APHE526-LEU540
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
FTYR196-HIS202
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues92
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues60
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues300
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues64
DetailsTransmembrane: {"description":"Discontinuously helical; Name=3","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues72
DetailsTransmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues68
DetailsTransmembrane: {"description":"Discontinuously helical; Name=10","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues72
DetailsTransmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues120
DetailsIntramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues4
DetailsSite: {"description":"Important for anion transport"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsSite: {"description":"Important for anion-proton cotransport"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues4
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"1885574","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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