Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005764 | cellular_component | lysosome |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0051603 | biological_process | proteolysis involved in protein catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 301 |
| Chain | Residue |
| A | LYS72 |
| A | GLU114 |
| A | HIS115 |
| A | HOH405 |
| A | HOH436 |
| A | HOH498 |
| A | HOH499 |
| A | HOH502 |
| A | HOH540 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | ARG21 |
| A | ALA93 |
| A | LYS94 |
| A | HOH440 |
| A | HOH479 |
| A | HOH611 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | GLN10 |
| A | ASN119 |
| A | PRO203 |
| A | HOH415 |
| A | HOH462 |
| A | HOH473 |
| A | HOH521 |
| A | HOH553 |
| A | HOH630 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 304 |
| Chain | Residue |
| A | CYS98 |
| A | LYS100 |
| A | ASN122 |
| A | MES307 |
| A | HOH407 |
| A | HOH443 |
| A | HOH491 |
| A | HOH643 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 305 |
| Chain | Residue |
| A | ASN62 |
| A | ASN122 |
| A | MES307 |
| A | HOH404 |
| A | HOH409 |
| A | HOH566 |
| A | HOH582 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue MES A 306 |
| Chain | Residue |
| A | LYS39 |
| A | ASP43 |
| A | GLU44 |
| A | LEU45 |
| A | PRO46 |
| A | SER47 |
| A | SER85 |
| A | VAL107 |
| A | PRO203 |
| A | HOH463 |
| A | HOH536 |
| A | HOH576 |
| A | HOH593 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | binding site for residue MES A 307 |
| Chain | Residue |
| A | LEU1 |
| A | ASP55 |
| A | CYS56 |
| A | ALA57 |
| A | THR58 |
| A | ASN62 |
| A | LYS95 |
| A | ASN122 |
| A | LYS125 |
| A | SO4304 |
| A | SO4305 |
| A | HOH455 |
| A | HOH572 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | binding site for Ligand residues SCH A 25 through TRP A 26 bound to SER A 24 |
| Chain | Residue |
| A | GLN19 |
| A | GLY23 |
| A | SER24 |
| A | ALA27 |
| A | PHE28 |
| A | SER29 |
| A | VAL30 |
| A | LEU53 |
| A | GLY64 |
| A | GLY67 |
| A | GLY68 |
| A | MET70 |
| A | HIS162 |
| A | ALA163 |
| A | THR220 |
| A | ALA221 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGrCGSCWAfSV |
| Chain | Residue | Details |
| A | GLN19-VAL30 | |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LDHAVVAIGYG |
| Chain | Residue | Details |
| A | LEU160-GLY170 | |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvRNSWgtnWGerGYIkL |
| Chain | Residue | Details |
| A | TYR177-LEU196 | |
