4YWU
Structural insight into the substrate inhibition mechanism of NADP+-dependent succinic semialdehyde dehydrogenase from Streptococcus pyogenes
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| A | 0004777 | molecular_function | succinate-semialdehyde dehydrogenase (NAD+) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0036243 | molecular_function | succinate-semialdehyde dehydrogenase (NADP+) activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| B | 0004777 | molecular_function | succinate-semialdehyde dehydrogenase (NAD+) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0036243 | molecular_function | succinate-semialdehyde dehydrogenase (NADP+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue SSN A 501 |
| Chain | Residue |
| A | ASN132 |
| A | GLN137 |
| A | ARG140 |
| A | GLU229 |
| A | VAL262 |
| A | CYS263 |
| A | THR264 |
| A | PHE426 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 502 |
| Chain | Residue |
| A | ALA157 |
| A | SER158 |
| A | TYR188 |
| A | HOH616 |
| A | HOH647 |
| A | LYS155 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 503 |
| Chain | Residue |
| A | ALA308 |
| A | LYS311 |
| A | PRO338 |
| A | GLY339 |
| A | HIS340 |
| A | HOH651 |
| A | HOH727 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue SSN B 501 |
| Chain | Residue |
| B | ASN132 |
| B | GLN137 |
| B | ARG140 |
| B | THR206 |
| B | VAL262 |
| B | CYS263 |
| B | THR264 |
| B | HOH643 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| B | LYS155 |
| B | SER158 |
| B | TYR188 |
| B | HOH689 |
| B | HOH697 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| B | ALA308 |
| B | LYS311 |
| B | PRO338 |
| B | GLY339 |
| B | HIS340 |
| B | HOH701 |
| B | HOH723 |
