4YV5
Crystal Structure of Myotoxin II from Bothrops moojeni complexed to Suramin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004623 | molecular_function | phospholipase A2 activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0042130 | biological_process | negative regulation of T cell proliferation |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
| A | 0050482 | biological_process | arachidonate secretion |
| A | 0050832 | biological_process | defense response to fungus |
| A | 0090729 | molecular_function | toxin activity |
| B | 0004623 | molecular_function | phospholipase A2 activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006644 | biological_process | phospholipid metabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0031640 | biological_process | killing of cells of another organism |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0042130 | biological_process | negative regulation of T cell proliferation |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
| B | 0050482 | biological_process | arachidonate secretion |
| B | 0050832 | biological_process | defense response to fungus |
| B | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 201 |
| Chain | Residue |
| B | LYS20 |
| B | LYS115 |
| B | ARG118 |
| B | SO4202 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 202 |
| Chain | Residue |
| B | HOH351 |
| B | LYS16 |
| B | ASN17 |
| B | LYS20 |
| B | SO4201 |
| B | HOH301 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue PE4 B 203 |
| Chain | Residue |
| A | LYS7 |
| A | LEU10 |
| A | GLN11 |
| A | GLY15 |
| A | TYR75 |
| A | TRP77 |
| B | LYS7 |
| B | LEU10 |
| B | GLN11 |
| B | GLY15 |
| B | TYR75 |
| B | TRP77 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue 1PE B 204 |
| Chain | Residue |
| A | TYR121 |
| A | LYS123 |
| A | PRO125 |
| B | LEU2 |
| B | ILE9 |
| B | CYS29 |
| B | GLY30 |
| B | HIS48 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 205 |
| Chain | Residue |
| B | GLY33 |
| B | ARG34 |
| B | LYS53 |
| B | HOH302 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 206 |
| Chain | Residue |
| A | LYS38 |
| A | LYS116 |
| A | TYR117 |
| B | LYS116 |
| B | TYR117 |
| site_id | AC7 |
| Number of Residues | 30 |
| Details | binding site for residue SVR B 207 |
| Chain | Residue |
| A | PHE3 |
| A | LYS7 |
| A | LEU10 |
| A | ASN17 |
| A | PRO18 |
| A | CYS27 |
| A | LYS38 |
| A | ARG72 |
| A | PHE126 |
| A | CYS127 |
| A | LYS128 |
| A | SO4202 |
| A | SVR205 |
| A | HOH380 |
| B | ASN114 |
| B | LYS115 |
| B | LYS116 |
| B | TYR119 |
| B | TYR121 |
| B | LEU122 |
| B | PHE126 |
| B | HOH305 |
| B | HOH311 |
| B | HOH316 |
| B | HOH320 |
| B | HOH338 |
| B | HOH347 |
| B | HOH352 |
| B | HOH356 |
| B | HOH361 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 201 |
| Chain | Residue |
| A | LYS16 |
| A | LYS20 |
| A | LYS115 |
| A | ARG118 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | LYS16 |
| A | ASN17 |
| A | LYS20 |
| A | HOH301 |
| B | SVR207 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue 1PE A 203 |
| Chain | Residue |
| A | ILE9 |
| A | PRO18 |
| A | TYR22 |
| A | ASN28 |
| A | GLY30 |
| A | CYS45 |
| A | HIS48 |
| A | LYS49 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 204 |
| Chain | Residue |
| A | ARG34 |
| A | LYS53 |
| A | HOH372 |
| site_id | AD3 |
| Number of Residues | 33 |
| Details | binding site for residue SVR A 205 |
| Chain | Residue |
| A | HOH348 |
| A | HOH353 |
| A | HOH355 |
| A | HOH357 |
| A | HOH363 |
| A | HOH368 |
| A | HOH369 |
| B | PHE3 |
| B | GLY6 |
| B | LYS7 |
| B | LEU10 |
| B | ASN17 |
| B | PRO18 |
| B | CYS27 |
| B | LYS36 |
| B | LYS38 |
| B | ARG72 |
| B | PHE126 |
| B | CYS127 |
| B | LYS128 |
| B | SVR207 |
| B | HOH323 |
| B | HOH351 |
| A | ASN114 |
| A | LYS115 |
| A | LYS116 |
| A | TYR119 |
| A | TYR121 |
| A | LEU122 |
| A | PHE126 |
| A | HOH305 |
| A | HOH316 |
| A | HOH321 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 26 |
| Details | Region: {"description":"Important for membrane-damaging activities in eukaryotes and bacteria; heparin-binding","evidences":[{"source":"UniProtKB","id":"P24605","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Site: {"description":"Cationic membrane-docking site (MDoS)","evidences":[{"source":"PubMed","id":"29287778","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important residue of the cationic membrane-docking site (MDoS)","evidences":[{"source":"UniProtKB","id":"I6L8L6","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"29287778","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Hydrophobic membrane-disruption site (MDiS)","evidences":[{"source":"UniProtKB","id":"I6L8L6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Site: {"description":"Cationic membrane-docking site (MDoS)","evidences":[{"source":"UniProtKB","id":"I6L8L6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
