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4YUX

Crystal structure of Trypanosoma cruzi spermidine synthase in complex with 2H-1,4-benzothiazin-3-amine

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004766molecular_functionspermidine synthase activity
A0005829cellular_componentcytosol
A0006596biological_processpolyamine biosynthetic process
A0008295biological_processspermidine biosynthetic process
A0016740molecular_functiontransferase activity
B0003824molecular_functioncatalytic activity
B0004766molecular_functionspermidine synthase activity
B0005829cellular_componentcytosol
B0006596biological_processpolyamine biosynthetic process
B0008295biological_processspermidine biosynthetic process
B0016740molecular_functiontransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues20
Detailsbinding site for residue S4M A 501
ChainResidue
AGLN40
AASP120
AVAL123
AASP149
AGLY150
AASP168
ATHR169
ATHR170
APRO175
AALA176
ALEU179
ALEU59
A4JT502
AGLN64
AHIS74
AGLY95
AASP98
AVAL117
AASP118
AILE119

site_idAC2
Number of Residues8
Detailsbinding site for residue 4JT A 502
ChainResidue
AILE63
AGLN64
ATYR73
ATHR169
AGLN201
ATHR236
AS4M501
AHOH613

site_idAC3
Number of Residues21
Detailsbinding site for residue S4M B 501
ChainResidue
BGLN40
BLEU59
BGLN64
BTYR73
BHIS74
BGLY95
BASP98
BVAL117
BASP118
BILE119
BASP120
BVAL123
BASP149
BGLY150
BASP168
BTHR169
BTHR170
BPRO175
BALA176
BLEU179
B4JT502

site_idAC4
Number of Residues10
Detailsbinding site for residue 4JT B 502
ChainResidue
BILE63
BGLN64
BTYR73
BTHR169
BGLN201
BTHR236
BTYR237
BILE242
BS4M501
BHOH605

Functional Information from PROSITE/UniProt
site_idPS01330
Number of Residues14
DetailsPABS_1 Polyamine biosynthesis (PABS) domain signature. VLIIGGGdGgvLrE
ChainResidueDetails
AVAL91-GLU104

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PDB entries from 2025-12-24

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