4YU0

Crystal structure of a tetramer of GluA2 TR mutant ligand binding domains bound with glutamate at 1.26 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue GLU A 301

Chain	Residue
A	TYR61
A	TYR220
A	HOH489
A	HOH449
A	HOH403
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193

---

site_id	AC2
Number of Residues	4
Details	binding site for residue PO4 A 302

Chain	Residue
A	HIS46
A	LYS240
A	HOH481
A	HOH435

---

site_id	AC3
Number of Residues	9
Details	binding site for residue PO4 A 303

Chain	Residue
A	ARG203
A	LYS258
A	HOH453
A	HOH671
A	HOH718
A	HOH732
A	HOH421
A	HOH441
A	HOH414

---

site_id	AC4
Number of Residues	11
Details	binding site for residue PO4 A 304

Chain	Residue
A	ALA63
A	SER140
A	LYS144
A	ARG148
A	HOH487
A	HOH430
A	HOH429
A	HOH422
A	HOH437
A	HOH653
A	HOH686

---

site_id	AC5
Number of Residues	2
Details	binding site for residue PEG A 305

Chain	Residue
A	SER217
A	HOH456

---

site_id	AC6
Number of Residues	5
Details	binding site for residue PEG A 306

Chain	Residue
A	LEU239
A	ASN242
A	GLU243
A	HOH417
A	HOH617

---

site_id	AC7
Number of Residues	13
Details	binding site for residue GLU B 301

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	GLU193
B	TYR220
B	HOH496
B	HOH489
B	HOH443

---

site_id	AC8
Number of Residues	9
Details	binding site for residue PO4 B 302

Chain	Residue
B	ALA63
B	SER140
B	LYS144
B	ARG148
B	PO4304
B	HOH469
B	HOH512
B	HOH424
B	HOH445

---

site_id	AC9
Number of Residues	3
Details	binding site for residue PO4 B 303

Chain	Residue
B	HIS46
B	LYS240
B	HOH456

---

site_id	AD1
Number of Residues	6
Details	binding site for residue PO4 B 304

Chain	Residue
A	LYS185
B	LYS144
B	ARG163
B	PO4302
B	HOH469
B	HOH410

---

site_id	AD2
Number of Residues	9
Details	binding site for residue PEG B 305

Chain	Residue
B	PRO105
B	PHE106
B	SER108
B	ASN242
B	ASP248
B	HOH473
B	HOH587
B	HOH600
B	HOH423

---

site_id	AD3
Number of Residues	5
Details	binding site for residue PEG B 306

Chain	Residue
B	GLU33
B	LYS253
B	TRP254
B	LYS258
B	HOH682

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---