Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4YTX

Crystal structure of Ups1-Mdm35 complex with PA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003674	molecular_function	molecular_function
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0006869	biological_process	lipid transport
A	0007005	biological_process	mitochondrion organization
A	0015914	biological_process	phospholipid transport
A	0033108	biological_process	mitochondrial respiratory chain complex assembly
A	0097035	biological_process	regulation of membrane lipid distribution
A	0120010	biological_process	intermembrane phospholipid transfer
A	1990050	molecular_function	phosphatidic acid transfer activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005758	cellular_component	mitochondrial intermembrane space
B	0006869	biological_process	lipid transport
B	0008289	molecular_function	lipid binding
B	0015914	biological_process	phospholipid transport
B	0032048	biological_process	cardiolipin metabolic process
B	0120010	biological_process	intermembrane phospholipid transfer
B	1990050	molecular_function	phosphatidic acid transfer activity
B	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
C	0003674	molecular_function	molecular_function
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005758	cellular_component	mitochondrial intermembrane space
C	0006869	biological_process	lipid transport
C	0007005	biological_process	mitochondrion organization
C	0015914	biological_process	phospholipid transport
C	0033108	biological_process	mitochondrial respiratory chain complex assembly
C	0097035	biological_process	regulation of membrane lipid distribution
C	0120010	biological_process	intermembrane phospholipid transfer
C	1990050	molecular_function	phosphatidic acid transfer activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005758	cellular_component	mitochondrial intermembrane space
D	0006869	biological_process	lipid transport
D	0008289	molecular_function	lipid binding
D	0015914	biological_process	phospholipid transport
D	0032048	biological_process	cardiolipin metabolic process
D	0120010	biological_process	intermembrane phospholipid transfer
D	1990050	molecular_function	phosphatidic acid transfer activity
D	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
E	0003674	molecular_function	molecular_function
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005758	cellular_component	mitochondrial intermembrane space
E	0006869	biological_process	lipid transport
E	0007005	biological_process	mitochondrion organization
E	0015914	biological_process	phospholipid transport
E	0033108	biological_process	mitochondrial respiratory chain complex assembly
E	0097035	biological_process	regulation of membrane lipid distribution
E	0120010	biological_process	intermembrane phospholipid transfer
E	1990050	molecular_function	phosphatidic acid transfer activity
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005758	cellular_component	mitochondrial intermembrane space
F	0006869	biological_process	lipid transport
F	0008289	molecular_function	lipid binding
F	0015914	biological_process	phospholipid transport
F	0032048	biological_process	cardiolipin metabolic process
F	0120010	biological_process	intermembrane phospholipid transfer
F	1990050	molecular_function	phosphatidic acid transfer activity
F	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
G	0003674	molecular_function	molecular_function
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005758	cellular_component	mitochondrial intermembrane space
G	0006869	biological_process	lipid transport
G	0007005	biological_process	mitochondrion organization
G	0015914	biological_process	phospholipid transport
G	0033108	biological_process	mitochondrial respiratory chain complex assembly
G	0097035	biological_process	regulation of membrane lipid distribution
G	0120010	biological_process	intermembrane phospholipid transfer
G	1990050	molecular_function	phosphatidic acid transfer activity
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005758	cellular_component	mitochondrial intermembrane space
H	0006869	biological_process	lipid transport
H	0008289	molecular_function	lipid binding
H	0015914	biological_process	phospholipid transport
H	0032048	biological_process	cardiolipin metabolic process
H	0120010	biological_process	intermembrane phospholipid transfer
H	1990050	molecular_function	phosphatidic acid transfer activity
H	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
I	0003674	molecular_function	molecular_function
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005758	cellular_component	mitochondrial intermembrane space
I	0006869	biological_process	lipid transport
I	0007005	biological_process	mitochondrion organization
I	0015914	biological_process	phospholipid transport
I	0033108	biological_process	mitochondrial respiratory chain complex assembly
I	0097035	biological_process	regulation of membrane lipid distribution
I	0120010	biological_process	intermembrane phospholipid transfer
I	1990050	molecular_function	phosphatidic acid transfer activity
J	0005515	molecular_function	protein binding
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005758	cellular_component	mitochondrial intermembrane space
J	0006869	biological_process	lipid transport
J	0008289	molecular_function	lipid binding
J	0015914	biological_process	phospholipid transport
J	0032048	biological_process	cardiolipin metabolic process
J	0120010	biological_process	intermembrane phospholipid transfer
J	1990050	molecular_function	phosphatidic acid transfer activity
J	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
K	0003674	molecular_function	molecular_function
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005758	cellular_component	mitochondrial intermembrane space
K	0006869	biological_process	lipid transport
K	0007005	biological_process	mitochondrion organization
K	0015914	biological_process	phospholipid transport
K	0033108	biological_process	mitochondrial respiratory chain complex assembly
K	0097035	biological_process	regulation of membrane lipid distribution
K	0120010	biological_process	intermembrane phospholipid transfer
K	1990050	molecular_function	phosphatidic acid transfer activity
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005758	cellular_component	mitochondrial intermembrane space
L	0006869	biological_process	lipid transport
L	0008289	molecular_function	lipid binding
L	0015914	biological_process	phospholipid transport
L	0032048	biological_process	cardiolipin metabolic process
L	0120010	biological_process	intermembrane phospholipid transfer
L	1990050	molecular_function	phosphatidic acid transfer activity
L	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
M	0003674	molecular_function	molecular_function
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005758	cellular_component	mitochondrial intermembrane space
M	0006869	biological_process	lipid transport
M	0007005	biological_process	mitochondrion organization
M	0015914	biological_process	phospholipid transport
M	0033108	biological_process	mitochondrial respiratory chain complex assembly
M	0097035	biological_process	regulation of membrane lipid distribution
M	0120010	biological_process	intermembrane phospholipid transfer
M	1990050	molecular_function	phosphatidic acid transfer activity
N	0005515	molecular_function	protein binding
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005758	cellular_component	mitochondrial intermembrane space
N	0006869	biological_process	lipid transport
N	0008289	molecular_function	lipid binding
N	0015914	biological_process	phospholipid transport
N	0032048	biological_process	cardiolipin metabolic process
N	0120010	biological_process	intermembrane phospholipid transfer
N	1990050	molecular_function	phosphatidic acid transfer activity
N	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
O	0003674	molecular_function	molecular_function
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005739	cellular_component	mitochondrion
O	0005758	cellular_component	mitochondrial intermembrane space
O	0006869	biological_process	lipid transport
O	0007005	biological_process	mitochondrion organization
O	0015914	biological_process	phospholipid transport
O	0033108	biological_process	mitochondrial respiratory chain complex assembly
O	0097035	biological_process	regulation of membrane lipid distribution
O	0120010	biological_process	intermembrane phospholipid transfer
O	1990050	molecular_function	phosphatidic acid transfer activity
P	0005515	molecular_function	protein binding
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0005758	cellular_component	mitochondrial intermembrane space
P	0006869	biological_process	lipid transport
P	0008289	molecular_function	lipid binding
P	0015914	biological_process	phospholipid transport
P	0032048	biological_process	cardiolipin metabolic process
P	0120010	biological_process	intermembrane phospholipid transfer
P	1990050	molecular_function	phosphatidic acid transfer activity
P	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue PX2 B 201

Chain	Residue
B	TYR26
B	VAL106
N	ASN152
B	HIS33
B	LYS58
B	THR76
B	ILE78
B	THR95
B	ASN97
B	HIS100
B	ILE103

site_id	AC2
Number of Residues	13
Details	binding site for residue PX2 F 201

Chain	Residue
D	PHE149
D	ASN152
D	SER156
F	TYR26
F	HIS33
F	LYS58
F	SER59
F	GLU75
F	THR76
F	THR95
F	ASN97
F	VAL106
F	GLU108

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	400
Details	Domain: {"description":"CHCH","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	80
Details	Motif: {"description":"Cx9C motif 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	80
Details	Motif: {"description":"Cx9C motif 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	395
Details	Region: {"description":"Required for mitochondrial targeting","evidences":[{"source":"PubMed","id":"16754953","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26235513","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26071601","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26071601","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26235513","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)