Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4YTX

Crystal structure of Ups1-Mdm35 complex with PA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003674	molecular_function	molecular_function
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0006869	biological_process	lipid transport
A	0007005	biological_process	mitochondrion organization
A	0015914	biological_process	phospholipid transport
A	0033108	biological_process	mitochondrial respiratory chain complex assembly
A	0045332	biological_process	phospholipid translocation
A	0120009	biological_process	intermembrane lipid transfer
A	1990050	molecular_function	phosphatidic acid transfer activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005758	cellular_component	mitochondrial intermembrane space
B	0006869	biological_process	lipid transport
B	0008289	molecular_function	lipid binding
B	0015914	biological_process	phospholipid transport
B	0032048	biological_process	cardiolipin metabolic process
B	0045332	biological_process	phospholipid translocation
B	0120009	biological_process	intermembrane lipid transfer
B	1990050	molecular_function	phosphatidic acid transfer activity
B	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
C	0003674	molecular_function	molecular_function
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005758	cellular_component	mitochondrial intermembrane space
C	0006869	biological_process	lipid transport
C	0007005	biological_process	mitochondrion organization
C	0015914	biological_process	phospholipid transport
C	0033108	biological_process	mitochondrial respiratory chain complex assembly
C	0045332	biological_process	phospholipid translocation
C	0120009	biological_process	intermembrane lipid transfer
C	1990050	molecular_function	phosphatidic acid transfer activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005758	cellular_component	mitochondrial intermembrane space
D	0006869	biological_process	lipid transport
D	0008289	molecular_function	lipid binding
D	0015914	biological_process	phospholipid transport
D	0032048	biological_process	cardiolipin metabolic process
D	0045332	biological_process	phospholipid translocation
D	0120009	biological_process	intermembrane lipid transfer
D	1990050	molecular_function	phosphatidic acid transfer activity
D	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
E	0003674	molecular_function	molecular_function
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005758	cellular_component	mitochondrial intermembrane space
E	0006869	biological_process	lipid transport
E	0007005	biological_process	mitochondrion organization
E	0015914	biological_process	phospholipid transport
E	0033108	biological_process	mitochondrial respiratory chain complex assembly
E	0045332	biological_process	phospholipid translocation
E	0120009	biological_process	intermembrane lipid transfer
E	1990050	molecular_function	phosphatidic acid transfer activity
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005758	cellular_component	mitochondrial intermembrane space
F	0006869	biological_process	lipid transport
F	0008289	molecular_function	lipid binding
F	0015914	biological_process	phospholipid transport
F	0032048	biological_process	cardiolipin metabolic process
F	0045332	biological_process	phospholipid translocation
F	0120009	biological_process	intermembrane lipid transfer
F	1990050	molecular_function	phosphatidic acid transfer activity
F	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
G	0003674	molecular_function	molecular_function
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005758	cellular_component	mitochondrial intermembrane space
G	0006869	biological_process	lipid transport
G	0007005	biological_process	mitochondrion organization
G	0015914	biological_process	phospholipid transport
G	0033108	biological_process	mitochondrial respiratory chain complex assembly
G	0045332	biological_process	phospholipid translocation
G	0120009	biological_process	intermembrane lipid transfer
G	1990050	molecular_function	phosphatidic acid transfer activity
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005758	cellular_component	mitochondrial intermembrane space
H	0006869	biological_process	lipid transport
H	0008289	molecular_function	lipid binding
H	0015914	biological_process	phospholipid transport
H	0032048	biological_process	cardiolipin metabolic process
H	0045332	biological_process	phospholipid translocation
H	0120009	biological_process	intermembrane lipid transfer
H	1990050	molecular_function	phosphatidic acid transfer activity
H	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
I	0003674	molecular_function	molecular_function
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005758	cellular_component	mitochondrial intermembrane space
I	0006869	biological_process	lipid transport
I	0007005	biological_process	mitochondrion organization
I	0015914	biological_process	phospholipid transport
I	0033108	biological_process	mitochondrial respiratory chain complex assembly
I	0045332	biological_process	phospholipid translocation
I	0120009	biological_process	intermembrane lipid transfer
I	1990050	molecular_function	phosphatidic acid transfer activity
J	0005515	molecular_function	protein binding
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005758	cellular_component	mitochondrial intermembrane space
J	0006869	biological_process	lipid transport
J	0008289	molecular_function	lipid binding
J	0015914	biological_process	phospholipid transport
J	0032048	biological_process	cardiolipin metabolic process
J	0045332	biological_process	phospholipid translocation
J	0120009	biological_process	intermembrane lipid transfer
J	1990050	molecular_function	phosphatidic acid transfer activity
J	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
K	0003674	molecular_function	molecular_function
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005758	cellular_component	mitochondrial intermembrane space
K	0006869	biological_process	lipid transport
K	0007005	biological_process	mitochondrion organization
K	0015914	biological_process	phospholipid transport
K	0033108	biological_process	mitochondrial respiratory chain complex assembly
K	0045332	biological_process	phospholipid translocation
K	0120009	biological_process	intermembrane lipid transfer
K	1990050	molecular_function	phosphatidic acid transfer activity
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005758	cellular_component	mitochondrial intermembrane space
L	0006869	biological_process	lipid transport
L	0008289	molecular_function	lipid binding
L	0015914	biological_process	phospholipid transport
L	0032048	biological_process	cardiolipin metabolic process
L	0045332	biological_process	phospholipid translocation
L	0120009	biological_process	intermembrane lipid transfer
L	1990050	molecular_function	phosphatidic acid transfer activity
L	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
M	0003674	molecular_function	molecular_function
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005758	cellular_component	mitochondrial intermembrane space
M	0006869	biological_process	lipid transport
M	0007005	biological_process	mitochondrion organization
M	0015914	biological_process	phospholipid transport
M	0033108	biological_process	mitochondrial respiratory chain complex assembly
M	0045332	biological_process	phospholipid translocation
M	0120009	biological_process	intermembrane lipid transfer
M	1990050	molecular_function	phosphatidic acid transfer activity
N	0005515	molecular_function	protein binding
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005758	cellular_component	mitochondrial intermembrane space
N	0006869	biological_process	lipid transport
N	0008289	molecular_function	lipid binding
N	0015914	biological_process	phospholipid transport
N	0032048	biological_process	cardiolipin metabolic process
N	0045332	biological_process	phospholipid translocation
N	0120009	biological_process	intermembrane lipid transfer
N	1990050	molecular_function	phosphatidic acid transfer activity
N	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process
O	0003674	molecular_function	molecular_function
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005739	cellular_component	mitochondrion
O	0005758	cellular_component	mitochondrial intermembrane space
O	0006869	biological_process	lipid transport
O	0007005	biological_process	mitochondrion organization
O	0015914	biological_process	phospholipid transport
O	0033108	biological_process	mitochondrial respiratory chain complex assembly
O	0045332	biological_process	phospholipid translocation
O	0120009	biological_process	intermembrane lipid transfer
O	1990050	molecular_function	phosphatidic acid transfer activity
P	0005515	molecular_function	protein binding
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0005758	cellular_component	mitochondrial intermembrane space
P	0006869	biological_process	lipid transport
P	0008289	molecular_function	lipid binding
P	0015914	biological_process	phospholipid transport
P	0032048	biological_process	cardiolipin metabolic process
P	0045332	biological_process	phospholipid translocation
P	0120009	biological_process	intermembrane lipid transfer
P	1990050	molecular_function	phosphatidic acid transfer activity
P	2001247	biological_process	positive regulation of phosphatidylcholine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue PX2 B 201

Chain	Residue
B	TYR26
B	VAL106
N	ASN152
B	HIS33
B	LYS58
B	THR76
B	ILE78
B	THR95
B	ASN97
B	HIS100
B	ILE103

site_id	AC2
Number of Residues	13
Details	binding site for residue PX2 F 201

Chain	Residue
D	PHE149
D	ASN152
D	SER156
F	TYR26
F	HIS33
F	LYS58
F	SER59
F	GLU75
F	THR76
F	THR95
F	ASN97
F	VAL106
F	GLU108

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:26235513

Chain	Residue	Details
B	TYR26
J	LYS58
L	TYR26
L	LYS58
N	TYR26
N	LYS58
P	TYR26
P	LYS58
B	LYS58
D	TYR26
D	LYS58
F	TYR26
F	LYS58
H	TYR26
H	LYS58
J	TYR26

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:26071601

Chain	Residue	Details
B	LYS148
D	LYS148
F	LYS148
H	LYS148
J	LYS148
L	LYS148
N	LYS148
P	LYS148

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:26071601, ECO:0000269\|PubMed:26235513

Chain	Residue	Details
B	ASN152
D	ASN152
F	ASN152
H	ASN152
J	ASN152
L	ASN152
N	ASN152
P	ASN152

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)