4YT7

Factor VIIa in complex with the inhibitor 2-(2-{(R)-[(4-carbamimidoylphenyl)amino][5-ethoxy-2-fluoro-3-(propan-2-yloxy)phenyl]methyl}-1H-imidazol-4-yl)benzamide

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue 4K1 H 301

Chain	Residue
H	LEU41
H	LYS192
H	SER195
H	SER214
H	TRP215
H	GLY216
H	GLN217
H	GLY219
H	GLY226
H	HOH474
H	HOH506
H	CYS42
H	HOH559
H	HIS57
H	LYS60
H	THR98
H	THR99
H	ASP102
H	ASP189
H	SER190

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CA H 302

Chain	Residue
H	GLU70
H	ASP72
H	GLU75
H	GLU80
H	HOH411
H	HOH495

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 H 303

Chain	Residue
H	ARG83
H	ARG84
H	HIS109
H	GLN110

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 H 304

Chain	Residue
H	VAL35
H	ASN37
H	ILE60
H	LYS60
H	ASN60

---

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 H 305

Chain	Residue
H	SER170
H	ILE176
H	HIS224
H	PHE225
H	VAL227
H	HOH406

---

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 H 306

Chain	Residue
H	ILE47
H	ASN48
H	GLN239
H	HOH403
H	HOH463
L	HIS115
L	GLU116

---

site_id	AC7
Number of Residues	7
Details	binding site for residue GOL H 307

Chain	Residue
H	PHE59
H	TRP61
H	PRO96
H	ARG147
H	HOH405
H	HOH480
H	HOH536

---

site_id	AC8
Number of Residues	3
Details	binding site for residue GOL H 308

Chain	Residue
H	GLU26
H	LEU137
L	ILE138

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
H	VAL53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA

Chain	Residue	Details
H	ASP189-ALA200

---

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CrCheGYslladgvsC

Chain	Residue	Details
L	CYS112-CYS127

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000250

Chain	Residue	Details
H	HIS57
H	ASP102
H	SER195

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
H	ASP189

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:3264725

Chain	Residue	Details
H	ASN175

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