4YRS
Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with N-(quinolin-3-yl)propanamide (Chem 1698)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004821 | molecular_function | histidine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006412 | biological_process | translation |
| A | 0006427 | biological_process | histidyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue HIS A 501 |
| Chain | Residue |
| A | GLU126 |
| A | PHE360 |
| A | GLY361 |
| A | HOH601 |
| A | HOH606 |
| A | THR128 |
| A | GLN170 |
| A | ASP174 |
| A | LEU316 |
| A | TYR318 |
| A | TYR319 |
| A | TYR342 |
| A | GLY359 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue 4JS A 502 |
| Chain | Residue |
| A | PRO125 |
| A | CYS154 |
| A | TRP155 |
| A | ARG156 |
| A | ARG165 |
| A | GLU167 |
| A | HIS168 |
| A | CYS365 |
