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4YRQ

Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 6-amino-2H-chromen-2-one (Chem 744)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004821molecular_functionhistidine-tRNA ligase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0006427biological_processhistidyl-tRNA aminoacylation
A0016874molecular_functionligase activity
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue HIS A 501
ChainResidue
AGLU126
AGLY359
APHE360
AGLY361
AHOH621
AHOH659
AHOH684
AHOH699
ATHR128
AGLN170
AASN172
AASP174
ALEU316
ATYR318
ATYR319
ATYR342

site_idAC2
Number of Residues7
Detailsbinding site for residue 4JQ A 502
ChainResidue
APRO125
ATRP155
AARG156
AARG165
AARG166
AGLU167
AHIS168

site_idAC3
Number of Residues5
Detailsbinding site for residue EDO A 503
ChainResidue
ATHR115
AGLY117
AHIS119
ATYR157
AARG166

site_idAC4
Number of Residues6
Detailsbinding site for residue DMS A 504
ChainResidue
AGLU96
ALEU97
AARG100
ATYR349
AHOH615
AHOH633

site_idAC5
Number of Residues2
Detailsbinding site for residue DMS A 505
ChainResidue
ATRP193
ASER197

site_idAC6
Number of Residues3
Detailsbinding site for residue SO4 A 506
ChainResidue
AARG69
AARG69
AHIS76

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PDB entries from 2024-10-30

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