4YRC

Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 2-aminoquinolin-8-ol (Chem 89)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004821	molecular_function	histidine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006412	biological_process	translation
A	0006427	biological_process	histidyl-tRNA aminoacylation
A	0016874	molecular_function	ligase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue HIS A 501

Chain	Residue
A	GLU126
A	GLY359
A	PHE360
A	GLY361
A	HOH606
A	HOH635
A	HOH674
A	THR128
A	GLN170
A	ASN172
A	ASP174
A	LEU316
A	TYR318
A	TYR319
A	TYR342

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site_id	AC2
Number of Residues	7
Details	binding site for residue 0P6 A 502

Chain	Residue
A	PRO125
A	CYS154
A	TRP155
A	ARG156
A	ARG165
A	GLU167
A	HIS168

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site_id	AC3
Number of Residues	4
Details	binding site for residue 0P6 A 503

Chain	Residue
A	VAL383
A	VAL384
A	GLY433
A	VAL435

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site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 504

Chain	Residue
A	ARG196
A	SER201
A	SER202
A	TRP305
A	HOH605

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site_id	AC5
Number of Residues	5
Details	binding site for residue DMS A 505

Chain	Residue
A	LEU97
A	ILE99
A	ARG100
A	THR348
A	TYR349

---

site_id	AC6
Number of Residues	4
Details	binding site for residue DMS A 506

Chain	Residue
A	LYS420
A	GLN424
A	ASN427
A	ASN427

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site_id	AC7
Number of Residues	4
Details	binding site for residue DMS A 507

Chain	Residue
A	TRP193
A	ARG196
A	SER197
A	TYR302

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site_id	AC8
Number of Residues	6
Details	binding site for residue EDO A 508

Chain	Residue
A	THR115
A	GLY117
A	HIS119
A	TYR157
A	THR161
A	ARG166

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site_id	AC9
Number of Residues	3
Details	binding site for residue SO4 A 509

Chain	Residue
A	ARG69
A	ARG69
A	HIS76

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