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4YR9

mouse TDH with NAD+ bound

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
B0003824molecular_functioncatalytic activity
C0003824molecular_functioncatalytic activity
D0003824molecular_functioncatalytic activity
E0003824molecular_functioncatalytic activity
F0003824molecular_functioncatalytic activity
Functional Information from PDB Data
site_idAC1
Number of Residues25
Detailsbinding site for residue NAD A 1001
ChainResidue
AGLY62
AILE107
ATYR128
ASER129
AALA130
ALEU132
AVAL146
APRO168
ATHR170
ATYR195
ALYS199
AGLY65
ATYR222
APRO223
AILE225
AGOL1002
AHOH1105
AHOH1107
AGLN66
ALEU67
AASP88
AILE89
AARG90
AALA105
AASN106

site_idAC2
Number of Residues7
Detailsbinding site for residue GOL A 1002
ChainResidue
ASER133
ATHR170
ATYR195
ATHR236
ATHR237
ATRP331
ANAD1001

site_idAC3
Number of Residues24
Detailsbinding site for residue NAD B 1001
ChainResidue
BGLY62
BGLY65
BGLN66
BLEU67
BASP88
BILE89
BARG90
BALA105
BASN106
BILE107
BTYR128
BSER129
BALA130
BLEU132
BVAL146
BPRO168
BSER169
BTHR170
BTYR195
BLYS199
BTYR222
BILE225
BGOL1002
BHOH1109

site_idAC4
Number of Residues8
Detailsbinding site for residue GOL B 1002
ChainResidue
BLEU132
BSER133
BTHR170
BTYR195
BTHR236
BTHR237
BTRP331
BNAD1001

site_idAC5
Number of Residues24
Detailsbinding site for residue NAD C 1001
ChainResidue
CGLY62
CGLY65
CGLN66
CLEU67
CASP88
CILE89
CARG90
CALA105
CASN106
CILE107
CTYR128
CSER129
CALA130
CVAL146
CPRO168
CSER169
CTHR170
CTYR195
CLYS199
CTYR222
CPRO223
CILE225
CGOL1002
CHOH1109

site_idAC6
Number of Residues8
Detailsbinding site for residue GOL C 1002
ChainResidue
CLEU132
CSER133
CTHR170
CTYR195
CTHR236
CTHR237
CTRP331
CNAD1001

site_idAC7
Number of Residues23
Detailsbinding site for residue NAD D 1001
ChainResidue
DLEU67
DASP88
DILE89
DARG90
DALA105
DASN106
DILE107
DTYR128
DSER129
DALA130
DLEU132
DPRO168
DSER169
DTHR170
DTYR195
DLYS199
DTYR222
DPRO223
DILE225
DHOH1109
DGLY62
DGLY65
DGLN66

site_idAC8
Number of Residues22
Detailsbinding site for residue NAD E 1001
ChainResidue
EGLY62
EGLY65
EGLN66
ELEU67
EASP88
EILE89
EARG90
EALA105
EASN106
EILE107
ETYR128
ESER129
EALA130
EPRO168
ESER169
ETHR170
ETYR195
ELYS199
ETYR222
EPRO223
EILE225
EHOH1101

site_idAC9
Number of Residues24
Detailsbinding site for residue NAD F 1001
ChainResidue
FGLY62
FGLY65
FGLN66
FLEU67
FASP88
FILE89
FARG90
FALA105
FASN106
FILE107
FTYR128
FSER129
FALA130
FLEU132
FVAL146
FPRO168
FSER169
FTHR170
FTYR195
FLYS199
FTYR222
FPRO223
FILE225
FHOH1107

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:26492815
ChainResidueDetails
ATYR195
BTYR195
CTYR195
DTYR195
ETYR195
FTYR195

site_idSWS_FT_FI2
Number of Residues36
DetailsBINDING: BINDING => ECO:0000269|PubMed:26492815, ECO:0007744|PDB:4YR9, ECO:0007744|PDB:4YRA, ECO:0007744|PDB:4YRB
ChainResidueDetails
AGLY62
BTYR195
BLYS199
BILE225
CGLY62
CASP88
CASN106
CTYR195
CLYS199
CILE225
DGLY62
AASP88
DASP88
DASN106
DTYR195
DLYS199
DILE225
EGLY62
EASP88
EASN106
ETYR195
ELYS199
AASN106
EILE225
FGLY62
FASP88
FASN106
FTYR195
FLYS199
FILE225
ATYR195
ALYS199
AILE225
BGLY62
BASP88
BASN106

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PDB entries from 2024-11-20

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