4YR9

mouse TDH with NAD+ bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
B	0003824	molecular_function	catalytic activity
C	0003824	molecular_function	catalytic activity
D	0003824	molecular_function	catalytic activity
E	0003824	molecular_function	catalytic activity
F	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	binding site for residue NAD A 1001

Chain	Residue
A	GLY62
A	ILE107
A	TYR128
A	SER129
A	ALA130
A	LEU132
A	VAL146
A	PRO168
A	THR170
A	TYR195
A	LYS199
A	GLY65
A	TYR222
A	PRO223
A	ILE225
A	GOL1002
A	HOH1105
A	HOH1107
A	GLN66
A	LEU67
A	ASP88
A	ILE89
A	ARG90
A	ALA105
A	ASN106

---

site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 1002

Chain	Residue
A	SER133
A	THR170
A	TYR195
A	THR236
A	THR237
A	TRP331
A	NAD1001

---

site_id	AC3
Number of Residues	24
Details	binding site for residue NAD B 1001

Chain	Residue
B	GLY62
B	GLY65
B	GLN66
B	LEU67
B	ASP88
B	ILE89
B	ARG90
B	ALA105
B	ASN106
B	ILE107
B	TYR128
B	SER129
B	ALA130
B	LEU132
B	VAL146
B	PRO168
B	SER169
B	THR170
B	TYR195
B	LYS199
B	TYR222
B	ILE225
B	GOL1002
B	HOH1109

---

site_id	AC4
Number of Residues	8
Details	binding site for residue GOL B 1002

Chain	Residue
B	LEU132
B	SER133
B	THR170
B	TYR195
B	THR236
B	THR237
B	TRP331
B	NAD1001

---

site_id	AC5
Number of Residues	24
Details	binding site for residue NAD C 1001

Chain	Residue
C	GLY62
C	GLY65
C	GLN66
C	LEU67
C	ASP88
C	ILE89
C	ARG90
C	ALA105
C	ASN106
C	ILE107
C	TYR128
C	SER129
C	ALA130
C	VAL146
C	PRO168
C	SER169
C	THR170
C	TYR195
C	LYS199
C	TYR222
C	PRO223
C	ILE225
C	GOL1002
C	HOH1109

---

site_id	AC6
Number of Residues	8
Details	binding site for residue GOL C 1002

Chain	Residue
C	LEU132
C	SER133
C	THR170
C	TYR195
C	THR236
C	THR237
C	TRP331
C	NAD1001

---

site_id	AC7
Number of Residues	23
Details	binding site for residue NAD D 1001

Chain	Residue
D	LEU67
D	ASP88
D	ILE89
D	ARG90
D	ALA105
D	ASN106
D	ILE107
D	TYR128
D	SER129
D	ALA130
D	LEU132
D	PRO168
D	SER169
D	THR170
D	TYR195
D	LYS199
D	TYR222
D	PRO223
D	ILE225
D	HOH1109
D	GLY62
D	GLY65
D	GLN66

---

site_id	AC8
Number of Residues	22
Details	binding site for residue NAD E 1001

Chain	Residue
E	GLY62
E	GLY65
E	GLN66
E	LEU67
E	ASP88
E	ILE89
E	ARG90
E	ALA105
E	ASN106
E	ILE107
E	TYR128
E	SER129
E	ALA130
E	PRO168
E	SER169
E	THR170
E	TYR195
E	LYS199
E	TYR222
E	PRO223
E	ILE225
E	HOH1101

---

site_id	AC9
Number of Residues	24
Details	binding site for residue NAD F 1001

Chain	Residue
F	GLY62
F	GLY65
F	GLN66
F	LEU67
F	ASP88
F	ILE89
F	ARG90
F	ALA105
F	ASN106
F	ILE107
F	TYR128
F	SER129
F	ALA130
F	LEU132
F	VAL146
F	PRO168
F	SER169
F	THR170
F	TYR195
F	LYS199
F	TYR222
F	PRO223
F	ILE225
F	HOH1107

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"26492815","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	66
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26492815","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YR9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YRA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YRB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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