4YMK
Crystal Structure of Stearoyl-Coenzyme A Desaturase 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004768 | molecular_function | stearoyl-CoA 9-desaturase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0006636 | biological_process | unsaturated fatty acid biosynthetic process |
| A | 0006641 | biological_process | triglyceride metabolic process |
| A | 0007584 | biological_process | response to nutrient |
| A | 0008610 | biological_process | lipid biosynthetic process |
| A | 0009617 | biological_process | response to bacterium |
| A | 0016020 | cellular_component | membrane |
| A | 0016215 | molecular_function | acyl-CoA desaturase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016717 | molecular_function | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
| A | 0032896 | molecular_function | palmitoyl-CoA 9-desaturase activity |
| A | 0042632 | biological_process | cholesterol homeostasis |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048733 | biological_process | sebaceous gland development |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0050872 | biological_process | white fat cell differentiation |
| A | 0050873 | biological_process | brown fat cell differentiation |
| A | 0055088 | biological_process | lipid homeostasis |
| A | 0055092 | biological_process | sterol homeostasis |
| A | 0070542 | biological_process | response to fatty acid |
| A | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| A | 1903699 | biological_process | tarsal gland development |
| A | 1903966 | biological_process | monounsaturated fatty acid biosynthetic process |
| D | 0004768 | molecular_function | stearoyl-CoA 9-desaturase activity |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0005783 | cellular_component | endoplasmic reticulum |
| D | 0005789 | cellular_component | endoplasmic reticulum membrane |
| D | 0006629 | biological_process | lipid metabolic process |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0006636 | biological_process | unsaturated fatty acid biosynthetic process |
| D | 0006641 | biological_process | triglyceride metabolic process |
| D | 0007584 | biological_process | response to nutrient |
| D | 0008610 | biological_process | lipid biosynthetic process |
| D | 0009617 | biological_process | response to bacterium |
| D | 0016020 | cellular_component | membrane |
| D | 0016215 | molecular_function | acyl-CoA desaturase activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016717 | molecular_function | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
| D | 0032896 | molecular_function | palmitoyl-CoA 9-desaturase activity |
| D | 0042632 | biological_process | cholesterol homeostasis |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0048733 | biological_process | sebaceous gland development |
| D | 0050830 | biological_process | defense response to Gram-positive bacterium |
| D | 0050872 | biological_process | white fat cell differentiation |
| D | 0050873 | biological_process | brown fat cell differentiation |
| D | 0055088 | biological_process | lipid homeostasis |
| D | 0055092 | biological_process | sterol homeostasis |
| D | 0070542 | biological_process | response to fatty acid |
| D | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| D | 1903699 | biological_process | tarsal gland development |
| D | 1903966 | biological_process | monounsaturated fatty acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | HIS116 |
| A | HIS121 |
| A | HIS153 |
| A | HIS157 |
| A | HIS297 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 402 |
| Chain | Residue |
| A | HOH542 |
| A | HIS156 |
| A | HIS265 |
| A | HIS294 |
| A | HIS298 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | binding site for residue ST9 A 403 |
| Chain | Residue |
| A | ASN71 |
| A | ILE111 |
| A | THR112 |
| A | HIS116 |
| A | PHE142 |
| A | GLN143 |
| A | ASN144 |
| A | TRP149 |
| A | ARG151 |
| A | ASP152 |
| A | HIS153 |
| A | TRP180 |
| A | LEU181 |
| A | VAL183 |
| A | ARG184 |
| A | LYS185 |
| A | VAL189 |
| A | GLY193 |
| A | GLY194 |
| A | ARG211 |
| A | THR257 |
| A | TRP258 |
| A | VAL260 |
| A | ASN261 |
| A | ALA288 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MPG A 404 |
| Chain | Residue |
| A | GLY100 |
| A | TYR104 |
| A | MET105 |
| A | LEU286 |
| A | VAL289 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue ZN D 401 |
| Chain | Residue |
| D | HIS116 |
| D | HIS121 |
| D | HIS153 |
| D | HIS157 |
| D | HIS297 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue ZN D 402 |
| Chain | Residue |
| D | HIS156 |
| D | HIS265 |
| D | HIS294 |
| D | HIS298 |
| D | HOH530 |
| site_id | AC7 |
| Number of Residues | 27 |
| Details | binding site for residue ST9 D 403 |
| Chain | Residue |
| D | ASN71 |
| D | ILE111 |
| D | THR112 |
| D | HIS116 |
| D | PHE142 |
| D | GLN143 |
| D | ASN144 |
| D | TRP149 |
| D | ARG151 |
| D | ASP152 |
| D | HIS153 |
| D | TRP180 |
| D | LEU181 |
| D | VAL183 |
| D | ARG184 |
| D | LYS185 |
| D | VAL189 |
| D | LYS190 |
| D | GLY193 |
| D | GLY194 |
| D | LEU254 |
| D | THR257 |
| D | TRP258 |
| D | ASN261 |
| D | GLY287 |
| D | ALA288 |
| D | HOH519 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue MPG D 404 |
| Chain | Residue |
| D | GLY100 |
| D | TYR104 |
| D | MET105 |
| D | LEU286 |
Functional Information from PROSITE/UniProt
| site_id | PS00476 |
| Number of Residues | 15 |
| Details | FATTY_ACID_DESATUR_1 Fatty acid desaturases family 1 signature. GEgFHNYHHtFPfDY |
| Chain | Residue | Details |
| A | GLY290-TYR304 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:26098370 |
| Chain | Residue | Details |
| A | TRP69-VAL89 | |
| A | LEU94-GLY114 | |
| A | TYR214-CYS233 | |
| A | PHE238-LEU259 | |
| D | TRP69-VAL89 | |
| D | LEU94-GLY114 | |
| D | TYR214-CYS233 | |
| D | PHE238-LEU259 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | TOPO_DOM: Lumenal => ECO:0000305|PubMed:26098370 |
| Chain | Residue | Details |
| A | PRO90-LYS93 | |
| A | TRP234-THR237 | |
| D | PRO90-LYS93 | |
| D | TRP234-THR237 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 196 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:26098370 |
| Chain | Residue | Details |
| A | ALA115-TYR213 | |
| D | ALA115-TYR213 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 190 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:16275639 |
| Chain | Residue | Details |
| A | VAL260-SER355 | |
| D | VAL260-SER355 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26098370 |
| Chain | Residue | Details |
| A | ASN71 | |
| D | ARG151 | |
| D | ASP152 | |
| D | ARG184 | |
| D | LYS185 | |
| D | TRP258 | |
| A | ASN144 | |
| A | ARG151 | |
| A | ASP152 | |
| A | ARG184 | |
| A | LYS185 | |
| A | TRP258 | |
| D | ASN71 | |
| D | ASN144 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:26098370 |
| Chain | Residue | Details |
| A | HIS116 | |
| D | HIS116 | |
| D | HIS121 | |
| D | HIS153 | |
| D | HIS156 | |
| D | HIS157 | |
| D | HIS265 | |
| D | HIS294 | |
| D | HIS297 | |
| D | HIS298 | |
| A | HIS121 | |
| A | HIS153 | |
| A | HIS156 | |
| A | HIS157 | |
| A | HIS265 | |
| A | HIS294 | |
| A | HIS297 | |
| A | HIS298 |
