4YL8

Crystal structure of the Crumbs/Moesin complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
A	0008092	molecular_function	cytoskeletal protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL A 301

Chain	Residue
A	ASN210
A	LYS211
A	LYS212
A	PHE267
A	VAL268
A	IOD320
A	HOH464

---

site_id	AC2
Number of Residues	1
Details	binding site for residue IOD A 302

Chain	Residue
A	LYS237

---

site_id	AC3
Number of Residues	1
Details	binding site for residue IOD A 303

Chain	Residue
A	GLN50

---

site_id	AC4
Number of Residues	1
Details	binding site for residue IOD A 304

Chain	Residue
A	SER207

---

site_id	AC5
Number of Residues	1
Details	binding site for residue IOD A 305

Chain	Residue
A	ARG171

---

site_id	AC6
Number of Residues	1
Details	binding site for residue IOD A 306

Chain	Residue
A	GLU199

---

site_id	AC7
Number of Residues	3
Details	binding site for residue IOD A 307

Chain	Residue
A	ARG275
A	IOD314
A	IOD316

---

site_id	AC8
Number of Residues	1
Details	binding site for residue IOD A 308

Chain	Residue
A	IOD320

---

site_id	AC9
Number of Residues	1
Details	binding site for residue IOD A 309

Chain	Residue
A	LYS72

---

site_id	AD1
Number of Residues	3
Details	binding site for residue IOD A 310

Chain	Residue
A	LEU152
A	LEU153
A	LEU158

---

site_id	AD2
Number of Residues	2
Details	binding site for residue IOD A 312

Chain	Residue
A	LYS63
A	LYS64

---

site_id	AD3
Number of Residues	4
Details	binding site for residue IOD A 313

Chain	Residue
A	THR4
A	PHE55
A	ARG275
A	ILE276

---

site_id	AD4
Number of Residues	2
Details	binding site for residue IOD A 314

Chain	Residue
A	ARG273
A	IOD307

---

site_id	AD5
Number of Residues	1
Details	binding site for residue IOD A 315

Chain	Residue
A	PRO119

---

site_id	AD6
Number of Residues	1
Details	binding site for residue IOD A 316

Chain	Residue
A	IOD307

---

site_id	AD7
Number of Residues	2
Details	binding site for residue IOD A 317

Chain	Residue
A	IOD318
A	HOH440

---

site_id	AD8
Number of Residues	6
Details	binding site for residue IOD A 318

Chain	Residue
A	TRP58
A	ARG279
A	IOD317
A	HOH533
A	HOH544
A	HOH566

---

site_id	AD9
Number of Residues	3
Details	binding site for residue IOD A 319

Chain	Residue
A	ARG100
A	SER132
A	HOH641

---

site_id	AE1
Number of Residues	2
Details	binding site for residue IOD A 320

Chain	Residue
A	GOL301
A	IOD308

---

site_id	AE2
Number of Residues	1
Details	binding site for residue IOD A 321

Chain	Residue
A	HOH641

---

site_id	AE3
Number of Residues	2
Details	binding site for residue IOD B 2201

Chain	Residue
B	LYS2112
B	IOD2202

---

site_id	AE4
Number of Residues	2
Details	binding site for residue IOD B 2202

Chain	Residue
B	THR2118
B	IOD2201

---

Functional Information from PROSITE/UniProt

site_id	PS00660
Number of Residues	31
Details	FERM_1 FERM domain signature 1. WLklnKkVtaQd.Vrkespll.FkfrakFYpeD

Chain	Residue	Details
A	TRP58-ASP88

---

site_id	PS00661
Number of Residues	30
Details	FERM_2 FERM domain signature 2. HeehrgmlreDAvleYLki.AqdLemYGvNY

Chain	Residue	Details
A	HIS176-TYR205

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	293
Details	Domain: {"description":"FERM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00084","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Motif: {"description":"[IL]-x-C-x-x-[DE] motif","evidences":[{"source":"UniProtKB","id":"P26038","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P26038","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P26038","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P26043","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"17947660","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"P26038","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---