4YKE
Crystal structure of eukaryotic Mre11 catalytic domain from Chaetomium thermophilum
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004520 | molecular_function | DNA endonuclease activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006302 | biological_process | double-strand break repair |
| A | 0008296 | molecular_function | 3'-5'-DNA exonuclease activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0030870 | cellular_component | Mre11 complex |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0004520 | molecular_function | DNA endonuclease activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006302 | biological_process | double-strand break repair |
| B | 0008296 | molecular_function | 3'-5'-DNA exonuclease activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0030870 | cellular_component | Mre11 complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 601 |
| Chain | Residue |
| A | ASP17 |
| A | HIS19 |
| A | ASP57 |
| A | HIS243 |
| A | MN602 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MN A 602 |
| Chain | Residue |
| A | HIS241 |
| A | MN601 |
| A | ASP17 |
| A | ASP57 |
| A | ASN124 |
| A | HIS213 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MN B 601 |
| Chain | Residue |
| B | ASP17 |
| B | HIS19 |
| B | ASP57 |
| B | HIS243 |
| B | MN602 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MN B 602 |
| Chain | Residue |
| B | ASP17 |
| B | ASP57 |
| B | ASN124 |
| B | HIS213 |
| B | HIS241 |
| B | MN601 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DPSGDGHLCslDL |
| Chain | Residue | Details |
| A | ASP127-LEU139 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PIRSR","id":"PIRSR000882-1","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26057807","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36577401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YKE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZR1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
