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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4YJL

Crystal structure of APC-ARM in complexed with Amer1-A2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008013	molecular_function	beta-catenin binding
A	0030178	biological_process	negative regulation of Wnt signaling pathway
B	0008013	molecular_function	beta-catenin binding
B	0030178	biological_process	negative regulation of Wnt signaling pathway
C	0008013	molecular_function	beta-catenin binding
C	0030178	biological_process	negative regulation of Wnt signaling pathway
D	0008013	molecular_function	beta-catenin binding
D	0030178	biological_process	negative regulation of Wnt signaling pathway
E	0008013	molecular_function	beta-catenin binding
E	0030178	biological_process	negative regulation of Wnt signaling pathway
F	0008013	molecular_function	beta-catenin binding
F	0030178	biological_process	negative regulation of Wnt signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EDO A 801

Chain	Residue
A	GLU536
A	SER537
A	GLU538
A	ASP539
A	LYS581
A	HOH1012

site_id	AC2
Number of Residues	5
Details	binding site for residue EDO A 802

Chain	Residue
A	GLN532
A	HOH1246
A	CYS483
A	GLY487
A	ARG498

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 803

Chain	Residue
A	HIS403
A	HIS405
A	MET406
A	HOH1247

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 804

Chain	Residue
A	PHE615
A	GLY618
A	THR619
A	EDO809

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 805

Chain	Residue
A	LEU669
A	MET706
A	ASN709

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 806

Chain	Residue
A	PRO437
A	GLU443
A	HIS444
A	HOH1058
D	HOH1275

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO A 807

Chain	Residue
A	ALA647
A	ARG653
A	ARG690
A	ASN691

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO A 808

Chain	Residue
A	LEU488
A	THR489
A	ASN490
A	ILE495
A	SER535
A	GLU536
A	HOH1257

site_id	AC9
Number of Residues	6
Details	binding site for residue EDO A 809

Chain	Residue
A	LYS580
A	GLU582
A	LEU585
A	TYR622
A	EDO804
A	HOH968

site_id	AD1
Number of Residues	7
Details	binding site for residue EDO B 801

Chain	Residue
B	CYS483
B	GLY487
B	LEU488
B	ARG498
B	ALA531
B	GLN532
B	HOH1232

site_id	AD2
Number of Residues	4
Details	binding site for residue EDO B 802

Chain	Residue
B	HIS403
B	HIS405
B	MET406
B	HOH1220

site_id	AD3
Number of Residues	5
Details	binding site for residue EDO B 803

Chain	Residue
B	LEU488
B	THR489
B	ASN490
B	SER535
B	GLU536

site_id	AD4
Number of Residues	4
Details	binding site for residue EDO B 804

Chain	Residue
B	PHE615
B	GLY618
B	THR619
B	TYR622

site_id	AD5
Number of Residues	4
Details	binding site for residue EDO B 805

Chain	Residue
B	VAL579
B	LYS580
B	GLU582
B	TYR622

site_id	AD6
Number of Residues	7
Details	binding site for residue EDO C 801

Chain	Residue
C	CYS483
C	GLY487
C	LEU488
C	ARG498
C	ALA531
C	GLN532
C	HOH1154

site_id	AD7
Number of Residues	6
Details	binding site for residue EDO C 802

Chain	Residue
C	ASN467
C	GLY470
C	GLY471
C	LEU472
C	GLN473
C	HOH1259

site_id	AD8
Number of Residues	5
Details	binding site for residue EDO C 803

Chain	Residue
C	ALA647
C	ARG653
C	ARG690
C	ASN691
C	HOH1256

site_id	AD9
Number of Residues	3
Details	binding site for residue EDO C 804

Chain	Residue
C	ARG527
C	GLU565
C	HOH1254

site_id	AE1
Number of Residues	9
Details	binding site for residue EDO C 805

Chain	Residue
C	CYS607
C	VAL609
C	ASP610
C	GLY611
C	ALA612
C	LEU613
C	ILE655
C	HOH1188
C	HOH1261

site_id	AE2
Number of Residues	7
Details	binding site for residue EDO D 801

Chain	Residue
D	GLY487
D	LEU488
D	ARG498
D	ALA528
D	GLN532
D	HOH1265
D	CYS483

site_id	AE3
Number of Residues	3
Details	binding site for residue EDO D 802

Chain	Residue
D	PHE615
D	GLY618
D	THR619

site_id	AE4
Number of Residues	4
Details	binding site for residue EDO D 803

Chain	Residue
D	HIS403
D	HIS405
D	MET406
D	HOH1145

site_id	AE5
Number of Residues	4
Details	binding site for residue EDO D 804

Chain	Residue
D	ALA647
D	ARG653
D	ARG690
D	ASN691

site_id	AE6
Number of Residues	7
Details	binding site for residue EDO D 805

Chain	Residue
D	GLY611
D	ALA612
D	LEU613
D	ALA614
D	ILE655
D	HOH1149
D	HOH1162

site_id	AE7
Number of Residues	6
Details	binding site for residue EDO D 806

Chain	Residue
D	ASN467
D	GLY470
D	GLY471
D	LEU472
D	GLN473
D	HOH1189

site_id	AE8
Number of Residues	6
Details	binding site for residue EDO D 807

Chain	Residue
D	PRO437
D	PRO439
D	GLU443
D	HOH1134
F	GLN445
F	HOH1279

site_id	AE9
Number of Residues	7
Details	binding site for residue EDO E 801

Chain	Residue
E	ASN467
E	GLY470
E	GLY471
E	LEU472
E	GLN473
E	ASN515
E	HOH908

site_id	AF1
Number of Residues	6
Details	binding site for residue EDO E 802

Chain	Residue
A	ARG690
E	GLU536
E	SER537
E	GLU538
E	ASP539
E	HOH1028

site_id	AF2
Number of Residues	4
Details	binding site for residue EDO E 803

Chain	Residue
E	PHE615
E	GLY618
E	THR619
E	TYR622

site_id	AF3
Number of Residues	4
Details	binding site for residue EDO E 804

Chain	Residue
E	PRO437
E	PRO439
E	GLU443
E	HIS444

site_id	AF4
Number of Residues	7
Details	binding site for residue EDO E 805

Chain	Residue
E	CYS483
E	GLY487
E	LEU488
E	ARG498
E	ALA528
E	GLN532
E	HOH1264

site_id	AF5
Number of Residues	4
Details	binding site for residue EDO E 806

Chain	Residue
E	HIS403
E	HIS405
E	MET406
E	HOH1148

site_id	AF6
Number of Residues	2
Details	binding site for residue EDO E 807

Chain	Residue
C	LYS455
E	GLU425

site_id	AF7
Number of Residues	3
Details	binding site for residue EDO F 801

Chain	Residue
F	PHE615
F	GLY618
F	THR619

site_id	AF8
Number of Residues	3
Details	binding site for residue EDO F 802

Chain	Residue
F	HIS405
F	MET406
F	HOH989

site_id	AF9
Number of Residues	5
Details	binding site for residue EDO F 803

Chain	Residue
F	LEU488
F	THR489
F	ASN490
F	SER535
F	GLU536

site_id	AG1
Number of Residues	7
Details	binding site for residue EDO F 804

Chain	Residue
F	ASN467
F	GLY470
F	GLY471
F	LEU472
F	GLN473
F	ASN515
F	HOH1226

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	252
Details	Repeat: {"description":"ARM 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	252
Details	Repeat: {"description":"ARM 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	258
Details	Repeat: {"description":"ARM 3"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	276
Details	Repeat: {"description":"ARM 4"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	264
Details	Repeat: {"description":"ARM 5"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	246
Details	Repeat: {"description":"ARM 6"}

Chain

Residue

Details

250059

PDB entries from 2026-03-04

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