4YGO
Dodecameric structure of spermidine N-acetyltransferase from Vibrio cholerae in intermediate state
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0004145 | molecular_function | diamine N-acetyltransferase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006598 | biological_process | polyamine catabolic process |
A | 0016746 | molecular_function | acyltransferase activity |
A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
A | 0046203 | biological_process | spermidine catabolic process |
A | 0046208 | biological_process | spermine catabolic process |
A | 0046872 | molecular_function | metal ion binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0004145 | molecular_function | diamine N-acetyltransferase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006598 | biological_process | polyamine catabolic process |
B | 0016746 | molecular_function | acyltransferase activity |
B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
B | 0046203 | biological_process | spermidine catabolic process |
B | 0046208 | biological_process | spermine catabolic process |
B | 0046872 | molecular_function | metal ion binding |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0004145 | molecular_function | diamine N-acetyltransferase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006598 | biological_process | polyamine catabolic process |
C | 0016746 | molecular_function | acyltransferase activity |
C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
C | 0046203 | biological_process | spermidine catabolic process |
C | 0046208 | biological_process | spermine catabolic process |
C | 0046872 | molecular_function | metal ion binding |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0004145 | molecular_function | diamine N-acetyltransferase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0006598 | biological_process | polyamine catabolic process |
D | 0016746 | molecular_function | acyltransferase activity |
D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
D | 0046203 | biological_process | spermidine catabolic process |
D | 0046208 | biological_process | spermine catabolic process |
D | 0046872 | molecular_function | metal ion binding |
E | 0000287 | molecular_function | magnesium ion binding |
E | 0004145 | molecular_function | diamine N-acetyltransferase activity |
E | 0005737 | cellular_component | cytoplasm |
E | 0006598 | biological_process | polyamine catabolic process |
E | 0016746 | molecular_function | acyltransferase activity |
E | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
E | 0046203 | biological_process | spermidine catabolic process |
E | 0046208 | biological_process | spermine catabolic process |
E | 0046872 | molecular_function | metal ion binding |
F | 0000287 | molecular_function | magnesium ion binding |
F | 0004145 | molecular_function | diamine N-acetyltransferase activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0006598 | biological_process | polyamine catabolic process |
F | 0016746 | molecular_function | acyltransferase activity |
F | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
F | 0046203 | biological_process | spermidine catabolic process |
F | 0046208 | biological_process | spermine catabolic process |
F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue CA A 201 |
Chain | Residue |
A | GLU33 |
A | GLU75 |
B | GLU33 |
B | GLU75 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue CA A 202 |
Chain | Residue |
A | PRO35 |
A | GLU41 |
A | HOH315 |
D | ASN53 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue CA B 201 |
Chain | Residue |
C | PRO35 |
C | GLU41 |
C | HOH322 |
B | ASN53 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue CA D 201 |
Chain | Residue |
C | GLU33 |
C | GLU75 |
D | GLU33 |
D | GLU75 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue CA D 202 |
Chain | Residue |
C | ASN53 |
C | HOH316 |
D | GLU34 |
D | PRO35 |
D | GLU41 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue CA E 201 |
Chain | Residue |
E | GLU33 |
E | GLU75 |
F | GLU33 |
F | GLU75 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P0A951 |
Chain | Residue | Details |
A | TYR134 | |
B | TYR134 | |
D | TYR134 | |
C | TYR134 | |
E | TYR134 | |
F | TYR134 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25623305, ECO:0000269|Ref.3, ECO:0007744|PDB:4MJ8 |
Chain | Residue | Details |
A | MET28 | |
E | GLU84 | |
F | MET28 | |
F | GLU84 | |
A | GLU84 | |
B | MET28 | |
B | GLU84 | |
D | MET28 | |
D | GLU84 | |
C | MET28 | |
C | GLU84 | |
E | MET28 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25623305, ECO:0007744|PDB:4MI4 |
Chain | Residue | Details |
A | GLU33 | |
B | GLU33 | |
D | GLU33 | |
C | GLU33 | |
E | GLU33 | |
F | GLU33 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25623305, ECO:0007744|PDB:4MI4, ECO:0007744|PDB:4R87 |
Chain | Residue | Details |
A | GLU41 | |
B | GLU41 | |
D | GLU41 | |
C | GLU41 | |
E | GLU41 | |
F | GLU41 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25623305, ECO:0007744|PDB:4R87 |
Chain | Residue | Details |
A | HIS49 | |
B | HIS49 | |
D | HIS49 | |
C | HIS49 | |
E | HIS49 | |
F | HIS49 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25623305, ECO:0000269|PubMed:26410587, ECO:0007744|PDB:5CNP |
Chain | Residue | Details |
A | GLU75 | |
B | GLU75 | |
D | GLU75 | |
C | GLU75 | |
E | GLU75 | |
F | GLU75 |
site_id | SWS_FT_FI7 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25623305, ECO:0007744|PDB:4R57, ECO:0007744|PDB:4R87 |
Chain | Residue | Details |
A | ILE87 | |
E | GLN94 | |
F | ILE87 | |
F | GLN94 | |
A | GLN94 | |
B | ILE87 | |
B | GLN94 | |
D | ILE87 | |
D | GLN94 | |
C | ILE87 | |
C | GLN94 | |
E | ILE87 |
site_id | SWS_FT_FI8 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25623305, ECO:0007744|PDB:4R57 |
Chain | Residue | Details |
A | ASN127 | |
B | ASN127 | |
D | ASN127 | |
C | ASN127 | |
E | ASN127 | |
F | ASN127 |
site_id | SWS_FT_FI9 |
Number of Residues | 6 |
Details | SITE: Could be important for selectivity toward long polyamines => ECO:0000305|PubMed:25623305 |
Chain | Residue | Details |
A | GLU84 | |
B | GLU84 | |
D | GLU84 | |
C | GLU84 | |
E | GLU84 | |
F | GLU84 |