Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4YGF

Crystal structure of the complex of Helicobacter pylori alpha-Carbonic Anhydrase with acetazolamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004089	molecular_function	carbonate dehydratase activity
A	0008270	molecular_function	zinc ion binding
A	0046872	molecular_function	metal ion binding
B	0004089	molecular_function	carbonate dehydratase activity
B	0008270	molecular_function	zinc ion binding
B	0046872	molecular_function	metal ion binding
C	0004089	molecular_function	carbonate dehydratase activity
C	0008270	molecular_function	zinc ion binding
C	0046872	molecular_function	metal ion binding
D	0004089	molecular_function	carbonate dehydratase activity
D	0008270	molecular_function	zinc ion binding
D	0046872	molecular_function	metal ion binding
E	0004089	molecular_function	carbonate dehydratase activity
E	0008270	molecular_function	zinc ion binding
E	0046872	molecular_function	metal ion binding
F	0004089	molecular_function	carbonate dehydratase activity
F	0008270	molecular_function	zinc ion binding
F	0046872	molecular_function	metal ion binding
G	0004089	molecular_function	carbonate dehydratase activity
G	0008270	molecular_function	zinc ion binding
G	0046872	molecular_function	metal ion binding
H	0004089	molecular_function	carbonate dehydratase activity
H	0008270	molecular_function	zinc ion binding
H	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	HIS110
A	HIS112
A	HIS129
A	AZM303

site_id	AC2
Number of Residues	6
Details	binding site for residue CL A 302

Chain	Residue
A	ALA143
A	MET115
A	GLU116
A	PHE117
A	SER127
A	HIS129

site_id	AC3
Number of Residues	11
Details	binding site for residue AZM A 303

Chain	Residue
A	ASN108
A	HIS110
A	HIS112
A	HIS129
A	VAL131
A	LEU190
A	THR191
A	TRP201
A	ZN301
A	GOL304
A	HOH446

site_id	AC4
Number of Residues	4
Details	binding site for residue GOL A 304

Chain	Residue
A	HIS84
A	THR86
A	HIS110
A	AZM303

site_id	AC5
Number of Residues	5
Details	binding site for residue ZN B 301

Chain	Residue
B	HIS110
B	HIS112
B	GLU116
B	HIS129
B	AZM303

site_id	AC6
Number of Residues	5
Details	binding site for residue CL B 302

Chain	Residue
B	MET115
B	GLU116
B	PHE117
B	SER127
B	HIS129

site_id	AC7
Number of Residues	11
Details	binding site for residue AZM B 303

Chain	Residue
B	ASN108
B	HIS110
B	HIS112
B	GLU116
B	HIS129
B	VAL131
B	LEU190
B	THR191
B	TRP201
B	ZN301
B	HOH482

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN C 301

Chain	Residue
C	HIS110
C	HIS112
C	HIS129
C	AZM303

site_id	AC9
Number of Residues	5
Details	binding site for residue CL C 302

Chain	Residue
C	MET115
C	GLU116
C	PHE117
C	SER127
C	HIS129

site_id	AD1
Number of Residues	11
Details	binding site for residue AZM C 303

Chain	Residue
C	ASN108
C	HIS110
C	HIS112
C	HIS129
C	VAL131
C	LEU190
C	THR191
C	TRP201
C	ZN301
C	GOL304
C	HOH514

site_id	AD2
Number of Residues	4
Details	binding site for residue GOL C 304

Chain	Residue
C	HIS84
C	THR86
C	ALA192
C	AZM303

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN D 301

Chain	Residue
D	HIS110
D	HIS112
D	HIS129
D	AZM303

site_id	AD4
Number of Residues	5
Details	binding site for residue CL D 302

Chain	Residue
D	MET115
D	PHE117
D	SER127
D	HIS129
D	ALA143

site_id	AD5
Number of Residues	11
Details	binding site for residue AZM D 303

Chain	Residue
D	ASN108
D	HIS110
D	HIS112
D	HIS129
D	VAL131
D	LEU190
D	THR191
D	TRP201
D	ZN301
D	HOH407
D	HOH443

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN E 301

Chain	Residue
E	HIS110
E	HIS112
E	HIS129
E	AZM303

site_id	AD7
Number of Residues	5
Details	binding site for residue CL E 302

Chain	Residue
E	MET115
E	GLU116
E	PHE117
E	SER127
E	HIS129

site_id	AD8
Number of Residues	11
Details	binding site for residue AZM E 303

Chain	Residue
E	LYS88
E	ASN108
E	HIS110
E	HIS112
E	HIS129
E	LEU190
E	THR191
E	TRP201
E	ZN301
E	GOL304
E	HOH455

site_id	AD9
Number of Residues	3
Details	binding site for residue GOL E 304

Chain	Residue
E	THR86
E	LYS88
E	AZM303

site_id	AE1
Number of Residues	4
Details	binding site for residue ZN F 301

Chain	Residue
F	HIS110
F	HIS112
F	HIS129
F	AZM303

site_id	AE2
Number of Residues	5
Details	binding site for residue CL F 302

Chain	Residue
F	MET115
F	GLU116
F	PHE117
F	SER127
F	HIS129

site_id	AE3
Number of Residues	9
Details	binding site for residue AZM F 303

Chain	Residue
F	ASN108
F	HIS110
F	HIS112
F	HIS129
F	VAL131
F	LEU190
F	THR191
F	TRP201
F	ZN301

site_id	AE4
Number of Residues	4
Details	binding site for residue ZN G 301

Chain	Residue
G	HIS110
G	HIS112
G	HIS129
G	AZM303

site_id	AE5
Number of Residues	5
Details	binding site for residue CL G 302

Chain	Residue
G	MET115
G	GLU116
G	PHE117
G	SER127
G	HIS129

site_id	AE6
Number of Residues	13
Details	binding site for residue AZM G 303

Chain	Residue
G	ASN108
G	HIS110
G	HIS112
G	HIS129
G	VAL131
G	LYS133
G	VAL141
G	LEU190
G	THR191
G	TRP201
G	ZN301
G	GOL304
G	HOH430

site_id	AE7
Number of Residues	4
Details	binding site for residue GOL G 304

Chain	Residue
G	HIS84
G	LYS88
G	HIS110
G	AZM303

site_id	AE8
Number of Residues	5
Details	binding site for residue ZN H 301

Chain	Residue
H	HIS110
H	HIS112
H	HIS129
H	AZM303
H	GOL304

site_id	AE9
Number of Residues	5
Details	binding site for residue CL H 302

Chain	Residue
H	MET115
H	GLU116
H	PHE117
H	SER127
H	HIS129

site_id	AF1
Number of Residues	12
Details	binding site for residue AZM H 303

Chain	Residue
H	ASN108
H	HIS110
H	HIS112
H	HIS129
H	VAL131
H	VAL141
H	LEU190
H	THR191
H	TRP201
H	ZN301
H	GOL304
H	HOH447

site_id	AF2
Number of Residues	5
Details	binding site for residue GOL H 304

Chain	Residue
H	THR86
H	HIS110
H	ALA192
H	ZN301
H	AZM303

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)