4YDG

Crystal structure of compound 10 in complex with HTLV-1 Protease

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004190	molecular_function	aspartic-type endopeptidase activity
B	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue SO4 A 201

Chain	Residue
A	ARG9
A	ARG9

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site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 202

Chain	Residue
A	SER22
A	HIS23
A	LYS25

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site_id	AC3
Number of Residues	11
Details	binding site for residue G3G B 201

Chain	Residue
B	ASP32
B	GLY34
B	ALA35
B	ASP36
B	MET37
B	LEU57
B	TRP98
A	ASP32
A	ASP36
A	TRP98
A	ILE100

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Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADMTVI

Chain	Residue	Details
A	ALA29-ILE40

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094

Chain	Residue	Details
A	ASP32
B	ASP32

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