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4YD2

Nicked complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A0005634cellular_componentnucleus
A0006281biological_processDNA repair
A0016779molecular_functionnucleotidyltransferase activity
A0034061molecular_functionDNA polymerase activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue NA A 501
ChainResidue
AASP330
AASP332
AASP418
PDA4
PDT5

site_idAC2
Number of Residues1
Detailsbinding site for residue CL A 502
ChainResidue
ALEU326

site_idAC3
Number of Residues5
Detailsbinding site for residue CL A 503
ChainResidue
AHOH610
AHOH630
ALEU431
ASER474
AGLU475

site_idAC4
Number of Residues5
Detailsbinding site for residue NA A 504
ChainResidue
AASP330
AASP332
APPV507
AHOH632
PDT5

site_idAC5
Number of Residues7
Detailsbinding site for residue NA A 505
ChainResidue
ATHR241
AGLN242
AILE243
AVAL246
AHOH659
PDT3
PHOH102

site_idAC6
Number of Residues3
Detailsbinding site for residue CL A 506
ChainResidue
ASER172
AGLY174
AARG175

site_idAC7
Number of Residues9
Detailsbinding site for residue PPV A 507
ChainResidue
AGLY319
AGLY320
AARG323
AASP332
ANA504
AHOH732
AHOH733
AHOH735
PDT5

Functional Information from PROSITE/UniProt
site_idPS00522
Number of Residues20
DetailsDNA_POLYMERASE_X DNA polymerase family X signature. GGFrRGklqGhDVDFLIthP
ChainResidueDetails
AGLY319-PRO338

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASP330
AASP332
AASP418

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Responsible for the low discrimination between dNTP and rNTP
ChainResidueDetails
AGLY433

226707

PDB entries from 2024-10-30

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