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4YD1

Ternary complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate and an incoming nonhydrolyzable dUMPNPP

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A0005634cellular_componentnucleus
A0006281biological_processDNA repair
A0016779molecular_functionnucleotidyltransferase activity
A0034061molecular_functionDNA polymerase activity
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue MG A 601
ChainResidue
AASP330
AASP332
AASP418
AMG602
ADUP607
AHOH770
PDA4

site_idAC2
Number of Residues5
Detailsbinding site for residue MG A 602
ChainResidue
AMG601
ADUP607
AHOH850
AASP330
AASP332

site_idAC3
Number of Residues4
Detailsbinding site for residue EDO A 603
ChainResidue
APRO190
ASER191
APRO192
AGLN198

site_idAC4
Number of Residues5
Detailsbinding site for residue GOL A 604
ChainResidue
ATRP455
APHE462
AHOH706
AHOH708
THOH202

site_idAC5
Number of Residues2
Detailsbinding site for residue GOL A 605
ChainResidue
AHOH704
AHOH717

site_idAC6
Number of Residues6
Detailsbinding site for residue EDO A 606
ChainResidue
AGLY433
AARG445
ASER458
ADUP607
AHOH786
PDA4

site_idAC7
Number of Residues27
Detailsbinding site for residue DUP A 607
ChainResidue
AGLY319
AGLY320
AARG323
ALYS325
AGLY328
AHIS329
AASP330
AASP332
AGLY433
ATRP434
AGLY436
AMG601
AMG602
AEDO606
AHOH702
AHOH749
AHOH770
AHOH773
AHOH797
AHOH814
AHOH834
AHOH850
AHOH904
AHOH922
AHOH932
PDA4
TDA5

site_idAC8
Number of Residues3
Detailsbinding site for residue CL A 608
ChainResidue
ASER172
AGLY174
AARG175

site_idAC9
Number of Residues4
Detailsbinding site for residue CL A 609
ChainResidue
ASER474
AGLU475
AHOH926
AHOH963

site_idAD1
Number of Residues1
Detailsbinding site for residue CL A 610
ChainResidue
ALEU326

site_idAD2
Number of Residues4
Detailsbinding site for residue CL A 611
ChainResidue
APHE385
AARG387
ATRP434
AHOH759

site_idAD3
Number of Residues7
Detailsbinding site for residue NA A 612
ChainResidue
ATHR241
AILE243
AVAL246
AHOH838
AHOH982
PDT3
PHOH114

site_idAD4
Number of Residues6
Detailsbinding site for residue MG T 101
ChainResidue
DHOH116
THOH207
THOH216
THOH223
THOH247
THOH255

Functional Information from PROSITE/UniProt
site_idPS00522
Number of Residues20
DetailsDNA_POLYMERASE_X DNA polymerase family X signature. GGFrRGklqGhDVDFLIthP
ChainResidueDetails
AGLY319-PRO338

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASP330
AASP332
AALA430

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Responsible for the low discrimination between dNTP and rNTP
ChainResidueDetails
AARG445

227344

PDB entries from 2024-11-13

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