4YC6

CDK1/CKS1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000082	biological_process	G1/S transition of mitotic cell cycle
A	0000086	biological_process	G2/M transition of mitotic cell cycle
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
A	0000781	cellular_component	chromosome, telomeric region
A	0001618	molecular_function	virus receptor activity
A	0003682	molecular_function	chromatin binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005813	cellular_component	centrosome
A	0005819	cellular_component	spindle
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005876	cellular_component	spindle microtubule
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006338	biological_process	chromatin remodeling
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006468	biological_process	protein phosphorylation
A	0006915	biological_process	apoptotic process
A	0006974	biological_process	DNA damage response
A	0007077	biological_process	mitotic nuclear membrane disassembly
A	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
A	0007098	biological_process	centrosome cycle
A	0007344	biological_process	pronuclear fusion
A	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
A	0009410	biological_process	response to xenobiotic stimulus
A	0009636	biological_process	response to toxic substance
A	0010628	biological_process	positive regulation of gene expression
A	0010629	biological_process	negative regulation of gene expression
A	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
A	0014038	biological_process	regulation of Schwann cell differentiation
A	0014070	biological_process	response to organic cyclic compound
A	0014075	biological_process	response to amine
A	0014823	biological_process	response to activity
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016477	biological_process	cell migration
A	0016579	biological_process	protein deubiquitination
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0018107	biological_process	peptidyl-threonine phosphorylation
A	0030261	biological_process	chromosome condensation
A	0030332	molecular_function	cyclin binding
A	0030496	cellular_component	midbody
A	0030544	molecular_function	Hsp70 protein binding
A	0030855	biological_process	epithelial cell differentiation
A	0031100	biological_process	animal organ regeneration
A	0034501	biological_process	protein localization to kinetochore
A	0035173	molecular_function	histone kinase activity
A	0042307	biological_process	positive regulation of protein import into nucleus
A	0042542	biological_process	response to hydrogen peroxide
A	0042752	biological_process	regulation of circadian rhythm
A	0043066	biological_process	negative regulation of apoptotic process
A	0044772	biological_process	mitotic cell cycle phase transition
A	0045471	biological_process	response to ethanol
A	0045740	biological_process	positive regulation of DNA replication
A	0045931	biological_process	positive regulation of mitotic cell cycle
A	0045995	biological_process	regulation of embryonic development
A	0046686	biological_process	response to cadmium ion
A	0046688	biological_process	response to copper ion
A	0046718	biological_process	symbiont entry into host cell
A	0048144	biological_process	fibroblast proliferation
A	0048511	biological_process	rhythmic process
A	0048678	biological_process	response to axon injury
A	0051301	biological_process	cell division
A	0055015	biological_process	ventricular cardiac muscle cell development
A	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
A	0062033	biological_process	positive regulation of mitotic sister chromatid segregation
A	0065003	biological_process	protein-containing complex assembly
A	0070062	cellular_component	extracellular exosome
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0070371	biological_process	ERK1 and ERK2 cascade
A	0071407	biological_process	cellular response to organic cyclic compound
A	0072686	cellular_component	mitotic spindle
A	0090166	biological_process	Golgi disassembly
A	0097121	cellular_component	cyclin A1-CDK1 complex
A	0097122	cellular_component	cyclin A2-CDK1 complex
A	0097125	cellular_component	cyclin B1-CDK1 complex
A	0097472	molecular_function	cyclin-dependent protein kinase activity
A	0106310	molecular_function	protein serine kinase activity
A	1900182	biological_process	positive regulation of protein localization to nucleus
A	1902423	biological_process	regulation of attachment of mitotic spindle microtubules to kinetochore
A	1902850	biological_process	microtubule cytoskeleton organization involved in mitosis
A	1905448	biological_process	positive regulation of mitochondrial ATP synthesis coupled electron transport
B	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0006355	biological_process	regulation of DNA-templated transcription
B	0007346	biological_process	regulation of mitotic cell cycle
B	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
B	0019005	cellular_component	SCF ubiquitin ligase complex
B	0019901	molecular_function	protein kinase binding
B	0042393	molecular_function	histone binding
B	0043130	molecular_function	ubiquitin binding
B	0044772	biological_process	mitotic cell cycle phase transition
B	0048144	biological_process	fibroblast proliferation
B	0051301	biological_process	cell division
B	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0000086	biological_process	G2/M transition of mitotic cell cycle
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
C	0000781	cellular_component	chromosome, telomeric region
C	0001618	molecular_function	virus receptor activity
C	0003682	molecular_function	chromatin binding
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005876	cellular_component	spindle microtubule
C	0006260	biological_process	DNA replication
C	0006281	biological_process	DNA repair
C	0006338	biological_process	chromatin remodeling
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006468	biological_process	protein phosphorylation
C	0006915	biological_process	apoptotic process
C	0006974	biological_process	DNA damage response
C	0007077	biological_process	mitotic nuclear membrane disassembly
C	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
C	0007098	biological_process	centrosome cycle
C	0007344	biological_process	pronuclear fusion
C	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
C	0009410	biological_process	response to xenobiotic stimulus
C	0009636	biological_process	response to toxic substance
C	0010628	biological_process	positive regulation of gene expression
C	0010629	biological_process	negative regulation of gene expression
C	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
C	0014038	biological_process	regulation of Schwann cell differentiation
C	0014070	biological_process	response to organic cyclic compound
C	0014075	biological_process	response to amine
C	0014823	biological_process	response to activity
C	0016020	cellular_component	membrane
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0016477	biological_process	cell migration
C	0016579	biological_process	protein deubiquitination
C	0018105	biological_process	peptidyl-serine phosphorylation
C	0018107	biological_process	peptidyl-threonine phosphorylation
C	0030261	biological_process	chromosome condensation
C	0030332	molecular_function	cyclin binding
C	0030496	cellular_component	midbody
C	0030544	molecular_function	Hsp70 protein binding
C	0030855	biological_process	epithelial cell differentiation
C	0031100	biological_process	animal organ regeneration
C	0034501	biological_process	protein localization to kinetochore
C	0035173	molecular_function	histone kinase activity
C	0042307	biological_process	positive regulation of protein import into nucleus
C	0042542	biological_process	response to hydrogen peroxide
C	0042752	biological_process	regulation of circadian rhythm
C	0043066	biological_process	negative regulation of apoptotic process
C	0044772	biological_process	mitotic cell cycle phase transition
C	0045471	biological_process	response to ethanol
C	0045740	biological_process	positive regulation of DNA replication
C	0045931	biological_process	positive regulation of mitotic cell cycle
C	0045995	biological_process	regulation of embryonic development
C	0046686	biological_process	response to cadmium ion
C	0046688	biological_process	response to copper ion
C	0046718	biological_process	symbiont entry into host cell
C	0048144	biological_process	fibroblast proliferation
C	0048511	biological_process	rhythmic process
C	0048678	biological_process	response to axon injury
C	0051301	biological_process	cell division
C	0055015	biological_process	ventricular cardiac muscle cell development
C	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
C	0062033	biological_process	positive regulation of mitotic sister chromatid segregation
C	0065003	biological_process	protein-containing complex assembly
C	0070062	cellular_component	extracellular exosome
C	0070301	biological_process	cellular response to hydrogen peroxide
C	0070371	biological_process	ERK1 and ERK2 cascade
C	0071407	biological_process	cellular response to organic cyclic compound
C	0072686	cellular_component	mitotic spindle
C	0090166	biological_process	Golgi disassembly
C	0097121	cellular_component	cyclin A1-CDK1 complex
C	0097122	cellular_component	cyclin A2-CDK1 complex
C	0097125	cellular_component	cyclin B1-CDK1 complex
C	0097472	molecular_function	cyclin-dependent protein kinase activity
C	0106310	molecular_function	protein serine kinase activity
C	1900182	biological_process	positive regulation of protein localization to nucleus
C	1902423	biological_process	regulation of attachment of mitotic spindle microtubules to kinetochore
C	1902850	biological_process	microtubule cytoskeleton organization involved in mitosis
C	1905448	biological_process	positive regulation of mitochondrial ATP synthesis coupled electron transport
D	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0006355	biological_process	regulation of DNA-templated transcription
D	0007346	biological_process	regulation of mitotic cell cycle
D	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
D	0019005	cellular_component	SCF ubiquitin ligase complex
D	0019901	molecular_function	protein kinase binding
D	0042393	molecular_function	histone binding
D	0043130	molecular_function	ubiquitin binding
D	0044772	biological_process	mitotic cell cycle phase transition
D	0048144	biological_process	fibroblast proliferation
D	0051301	biological_process	cell division
D	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity
E	0000082	biological_process	G1/S transition of mitotic cell cycle
E	0000086	biological_process	G2/M transition of mitotic cell cycle
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
E	0000781	cellular_component	chromosome, telomeric region
E	0001618	molecular_function	virus receptor activity
E	0003682	molecular_function	chromatin binding
E	0004672	molecular_function	protein kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005813	cellular_component	centrosome
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005876	cellular_component	spindle microtubule
E	0006260	biological_process	DNA replication
E	0006281	biological_process	DNA repair
E	0006338	biological_process	chromatin remodeling
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006468	biological_process	protein phosphorylation
E	0006915	biological_process	apoptotic process
E	0006974	biological_process	DNA damage response
E	0007077	biological_process	mitotic nuclear membrane disassembly
E	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
E	0007098	biological_process	centrosome cycle
E	0007344	biological_process	pronuclear fusion
E	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
E	0009410	biological_process	response to xenobiotic stimulus
E	0009636	biological_process	response to toxic substance
E	0010628	biological_process	positive regulation of gene expression
E	0010629	biological_process	negative regulation of gene expression
E	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
E	0014038	biological_process	regulation of Schwann cell differentiation
E	0014070	biological_process	response to organic cyclic compound
E	0014075	biological_process	response to amine
E	0014823	biological_process	response to activity
E	0016020	cellular_component	membrane
E	0016301	molecular_function	kinase activity
E	0016310	biological_process	phosphorylation
E	0016477	biological_process	cell migration
E	0016579	biological_process	protein deubiquitination
E	0018105	biological_process	peptidyl-serine phosphorylation
E	0018107	biological_process	peptidyl-threonine phosphorylation
E	0030261	biological_process	chromosome condensation
E	0030332	molecular_function	cyclin binding
E	0030496	cellular_component	midbody
E	0030544	molecular_function	Hsp70 protein binding
E	0030855	biological_process	epithelial cell differentiation
E	0031100	biological_process	animal organ regeneration
E	0034501	biological_process	protein localization to kinetochore
E	0035173	molecular_function	histone kinase activity
E	0042307	biological_process	positive regulation of protein import into nucleus
E	0042542	biological_process	response to hydrogen peroxide
E	0042752	biological_process	regulation of circadian rhythm
E	0043066	biological_process	negative regulation of apoptotic process
E	0044772	biological_process	mitotic cell cycle phase transition
E	0045471	biological_process	response to ethanol
E	0045740	biological_process	positive regulation of DNA replication
E	0045931	biological_process	positive regulation of mitotic cell cycle
E	0045995	biological_process	regulation of embryonic development
E	0046686	biological_process	response to cadmium ion
E	0046688	biological_process	response to copper ion
E	0046718	biological_process	symbiont entry into host cell
E	0048144	biological_process	fibroblast proliferation
E	0048511	biological_process	rhythmic process
E	0048678	biological_process	response to axon injury
E	0051301	biological_process	cell division
E	0055015	biological_process	ventricular cardiac muscle cell development
E	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
E	0062033	biological_process	positive regulation of mitotic sister chromatid segregation
E	0065003	biological_process	protein-containing complex assembly
E	0070062	cellular_component	extracellular exosome
E	0070301	biological_process	cellular response to hydrogen peroxide
E	0070371	biological_process	ERK1 and ERK2 cascade
E	0071407	biological_process	cellular response to organic cyclic compound
E	0072686	cellular_component	mitotic spindle
E	0090166	biological_process	Golgi disassembly
E	0097121	cellular_component	cyclin A1-CDK1 complex
E	0097122	cellular_component	cyclin A2-CDK1 complex
E	0097125	cellular_component	cyclin B1-CDK1 complex
E	0097472	molecular_function	cyclin-dependent protein kinase activity
E	0106310	molecular_function	protein serine kinase activity
E	1900182	biological_process	positive regulation of protein localization to nucleus
E	1902423	biological_process	regulation of attachment of mitotic spindle microtubules to kinetochore
E	1902850	biological_process	microtubule cytoskeleton organization involved in mitosis
E	1905448	biological_process	positive regulation of mitochondrial ATP synthesis coupled electron transport
F	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
F	0005515	molecular_function	protein binding
F	0005654	cellular_component	nucleoplasm
F	0006355	biological_process	regulation of DNA-templated transcription
F	0007346	biological_process	regulation of mitotic cell cycle
F	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
F	0019005	cellular_component	SCF ubiquitin ligase complex
F	0019901	molecular_function	protein kinase binding
F	0042393	molecular_function	histone binding
F	0043130	molecular_function	ubiquitin binding
F	0044772	biological_process	mitotic cell cycle phase transition
F	0048144	biological_process	fibroblast proliferation
F	0051301	biological_process	cell division
F	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity
G	0000082	biological_process	G1/S transition of mitotic cell cycle
G	0000086	biological_process	G2/M transition of mitotic cell cycle
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
G	0000781	cellular_component	chromosome, telomeric region
G	0001618	molecular_function	virus receptor activity
G	0003682	molecular_function	chromatin binding
G	0004672	molecular_function	protein kinase activity
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005813	cellular_component	centrosome
G	0005819	cellular_component	spindle
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005876	cellular_component	spindle microtubule
G	0006260	biological_process	DNA replication
G	0006281	biological_process	DNA repair
G	0006338	biological_process	chromatin remodeling
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0006468	biological_process	protein phosphorylation
G	0006915	biological_process	apoptotic process
G	0006974	biological_process	DNA damage response
G	0007077	biological_process	mitotic nuclear membrane disassembly
G	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
G	0007098	biological_process	centrosome cycle
G	0007344	biological_process	pronuclear fusion
G	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
G	0009410	biological_process	response to xenobiotic stimulus
G	0009636	biological_process	response to toxic substance
G	0010628	biological_process	positive regulation of gene expression
G	0010629	biological_process	negative regulation of gene expression
G	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
G	0014038	biological_process	regulation of Schwann cell differentiation
G	0014070	biological_process	response to organic cyclic compound
G	0014075	biological_process	response to amine
G	0014823	biological_process	response to activity
G	0016020	cellular_component	membrane
G	0016301	molecular_function	kinase activity
G	0016310	biological_process	phosphorylation
G	0016477	biological_process	cell migration
G	0016579	biological_process	protein deubiquitination
G	0018105	biological_process	peptidyl-serine phosphorylation
G	0018107	biological_process	peptidyl-threonine phosphorylation
G	0030261	biological_process	chromosome condensation
G	0030332	molecular_function	cyclin binding
G	0030496	cellular_component	midbody
G	0030544	molecular_function	Hsp70 protein binding
G	0030855	biological_process	epithelial cell differentiation
G	0031100	biological_process	animal organ regeneration
G	0034501	biological_process	protein localization to kinetochore
G	0035173	molecular_function	histone kinase activity
G	0042307	biological_process	positive regulation of protein import into nucleus
G	0042542	biological_process	response to hydrogen peroxide
G	0042752	biological_process	regulation of circadian rhythm
G	0043066	biological_process	negative regulation of apoptotic process
G	0044772	biological_process	mitotic cell cycle phase transition
G	0045471	biological_process	response to ethanol
G	0045740	biological_process	positive regulation of DNA replication
G	0045931	biological_process	positive regulation of mitotic cell cycle
G	0045995	biological_process	regulation of embryonic development
G	0046686	biological_process	response to cadmium ion
G	0046688	biological_process	response to copper ion
G	0046718	biological_process	symbiont entry into host cell
G	0048144	biological_process	fibroblast proliferation
G	0048511	biological_process	rhythmic process
G	0048678	biological_process	response to axon injury
G	0051301	biological_process	cell division
G	0055015	biological_process	ventricular cardiac muscle cell development
G	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
G	0062033	biological_process	positive regulation of mitotic sister chromatid segregation
G	0065003	biological_process	protein-containing complex assembly
G	0070062	cellular_component	extracellular exosome
G	0070301	biological_process	cellular response to hydrogen peroxide
G	0070371	biological_process	ERK1 and ERK2 cascade
G	0071407	biological_process	cellular response to organic cyclic compound
G	0072686	cellular_component	mitotic spindle
G	0090166	biological_process	Golgi disassembly
G	0097121	cellular_component	cyclin A1-CDK1 complex
G	0097122	cellular_component	cyclin A2-CDK1 complex
G	0097125	cellular_component	cyclin B1-CDK1 complex
G	0097472	molecular_function	cyclin-dependent protein kinase activity
G	0106310	molecular_function	protein serine kinase activity
G	1900182	biological_process	positive regulation of protein localization to nucleus
G	1902423	biological_process	regulation of attachment of mitotic spindle microtubules to kinetochore
G	1902850	biological_process	microtubule cytoskeleton organization involved in mitosis
G	1905448	biological_process	positive regulation of mitochondrial ATP synthesis coupled electron transport
H	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
H	0005515	molecular_function	protein binding
H	0005654	cellular_component	nucleoplasm
H	0006355	biological_process	regulation of DNA-templated transcription
H	0007346	biological_process	regulation of mitotic cell cycle
H	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
H	0019005	cellular_component	SCF ubiquitin ligase complex
H	0019901	molecular_function	protein kinase binding
H	0042393	molecular_function	histone binding
H	0043130	molecular_function	ubiquitin binding
H	0044772	biological_process	mitotic cell cycle phase transition
H	0048144	biological_process	fibroblast proliferation
H	0051301	biological_process	cell division
H	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGVVYkGrhkttgqv..........VAMK

Chain	Residue	Details
A	ILE10-LYS33

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI

Chain	Residue	Details
A	VAL124-ILE136

---

site_id	PS00944
Number of Residues	19
Details	CKS_1 Cyclin-dependent kinases regulatory subunits signature 1. YSdKYdDEeFEYRHVmLPK

Chain	Residue	Details
B	TYR8-LYS26

---

site_id	PS00945
Number of Residues	11
Details	CKS_2 Cyclin-dependent kinases regulatory subunits signature 2. HePEpHILLFR

Chain	Residue	Details
B	HIS60-ARG70

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
B	SER2
D	SER2
F	SER2
H	SER2

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE10
A	LYS33
C	ILE10
C	LYS33
E	ILE10
E	LYS33
G	ILE10
G	LYS33

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:22814378

Chain	Residue	Details
A	MET1
C	MET1
E	MET1
G	MET1

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by PKR => ECO:0000269|PubMed:20395957

Chain	Residue	Details
A	TYR4
C	TYR4
E	TYR4
G	TYR4

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS6
C	LYS6
E	LYS6
G	LYS6

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P11440

Chain	Residue	Details
A	LYS9
C	LYS9
E	LYS9
G	LYS9

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by PKMYT1 => ECO:0000269|PubMed:7569953, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	THR14
C	THR14
E	THR14
G	THR14

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by PKMYT1, WEE1, WEE2 and PKC/PRKCD => ECO:0000269|PubMed:19917613, ECO:0000269|PubMed:29606300, ECO:0000269|PubMed:7569953, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	TYR15
C	TYR15
E	TYR15
G	TYR15

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	TYR19
C	TYR19
E	TYR19
G	TYR19

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER39
C	SER39
E	SER39
G	SER39

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18691976

Chain	Residue	Details
A	TYR77
C	TYR77
E	TYR77
G	TYR77

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR141
C	THR141
E	THR141
G	THR141

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by CAK => ECO:0000269|PubMed:20360007, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR161
C	THR161
E	THR161
G	THR161

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	SER178
A	SER248
C	SER178
C	SER248
E	SER178
E	SER248
G	SER178
G	SER248

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	THR222
C	THR222
E	THR222
G	THR222

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P11440

Chain	Residue	Details
A	LYS245
C	LYS245
E	LYS245
G	LYS245

---

site_id	SWS_FT_FI17
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS6
A	LYS9
C	LYS6
C	LYS9
E	LYS6
E	LYS9
G	LYS6
G	LYS9

---

site_id	SWS_FT_FI18
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
G	LYS20
G	LYS139
A	LYS20
A	LYS139
C	LYS20
C	LYS139
E	LYS20
E	LYS139

---