4YBQ
Rat GLUT5 with Fv in the outward-open form
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003044 | biological_process | regulation of systemic arterial blood pressure mediated by a chemical signal |
A | 0005353 | molecular_function | fructose transmembrane transporter activity |
A | 0005355 | molecular_function | glucose transmembrane transporter activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0009750 | biological_process | response to fructose |
A | 0015149 | molecular_function | hexose transmembrane transporter activity |
A | 0015755 | biological_process | fructose transmembrane transport |
A | 0016020 | cellular_component | membrane |
A | 0016324 | cellular_component | apical plasma membrane |
A | 0022857 | molecular_function | transmembrane transporter activity |
A | 0042383 | cellular_component | sarcolemma |
A | 0055085 | biological_process | transmembrane transport |
A | 0070061 | molecular_function | fructose binding |
A | 0071332 | biological_process | cellular response to fructose stimulus |
A | 0072237 | biological_process | metanephric proximal tubule development |
A | 1904659 | biological_process | glucose transmembrane transport |
A | 1990539 | biological_process | fructose import across plasma membrane |
B | 0003044 | biological_process | regulation of systemic arterial blood pressure mediated by a chemical signal |
B | 0005353 | molecular_function | fructose transmembrane transporter activity |
B | 0005355 | molecular_function | glucose transmembrane transporter activity |
B | 0005886 | cellular_component | plasma membrane |
B | 0009750 | biological_process | response to fructose |
B | 0015149 | molecular_function | hexose transmembrane transporter activity |
B | 0015755 | biological_process | fructose transmembrane transport |
B | 0016020 | cellular_component | membrane |
B | 0016324 | cellular_component | apical plasma membrane |
B | 0022857 | molecular_function | transmembrane transporter activity |
B | 0042383 | cellular_component | sarcolemma |
B | 0055085 | biological_process | transmembrane transport |
B | 0070061 | molecular_function | fructose binding |
B | 0071332 | biological_process | cellular response to fructose stimulus |
B | 0072237 | biological_process | metanephric proximal tubule development |
B | 1904659 | biological_process | glucose transmembrane transport |
B | 1990539 | biological_process | fructose import across plasma membrane |
Functional Information from PROSITE/UniProt
site_id | PS00216 |
Number of Residues | 17 |
Details | SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. TVFVVELWGRRnllli.G |
Chain | Residue | Details |
A | THR331-GLY347 |
site_id | PS00217 |
Number of Residues | 26 |
Details | SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. LvGICaGIssnvvpmYlgElapknlR |
Chain | Residue | Details |
A | LEU133-ARG158 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 324 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26416735 |
Chain | Residue | Details |
A | MET1-ALA17 | |
B | LEU149-ALA160 | |
B | PRO213-GLN276 | |
B | VAL334-ARG341 | |
B | PRO394-TYR411 | |
B | PRO460-GLN502 | |
A | LEU91-ARG97 | |
A | LEU149-ALA160 | |
A | PRO213-GLN276 | |
A | VAL334-ARG341 | |
A | PRO394-TYR411 | |
A | PRO460-GLN502 | |
B | MET1-ALA17 | |
B | LEU91-ARG97 |
site_id | SWS_FT_FI2 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:26416735 |
Chain | Residue | Details |
A | LEU18-VAL38 | |
B | LEU18-VAL38 |
site_id | SWS_FT_FI3 |
Number of Residues | 138 |
Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:26416735 |
Chain | Residue | Details |
A | ASN39-THR67 | |
B | TYR298-ASP312 | |
B | ALA363-TRP370 | |
B | GLN433-PRO438 | |
A | LYS119-GLU125 | |
A | ARG182-TRP191 | |
A | TYR298-ASP312 | |
A | ALA363-TRP370 | |
A | GLN433-PRO438 | |
B | ASN39-THR67 | |
B | LYS119-GLU125 | |
B | ARG182-TRP191 |
site_id | SWS_FT_FI4 |
Number of Residues | 44 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:26416735 |
Chain | Residue | Details |
A | LEU68-PHE90 | |
B | LEU68-PHE90 |
site_id | SWS_FT_FI5 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:26416735 |
Chain | Residue | Details |
A | LYS98-SER118 | |
B | LYS98-SER118 |
site_id | SWS_FT_FI6 |
Number of Residues | 44 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:26416735 |
Chain | Residue | Details |
A | ILE126-TYR148 | |
B | ILE126-TYR148 |
site_id | SWS_FT_FI7 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:26416735 |
Chain | Residue | Details |
A | LEU161-LEU181 | |
B | LEU161-LEU181 |
site_id | SWS_FT_FI8 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:26416735 |
Chain | Residue | Details |
A | PRO192-PHE212 | |
B | PRO192-PHE212 |
site_id | SWS_FT_FI9 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:26416735 |
Chain | Residue | Details |
A | LEU277-TYR297 | |
B | LEU277-TYR297 |
site_id | SWS_FT_FI10 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:26416735 |
Chain | Residue | Details |
A | VAL313-PHE333 | |
B | VAL313-PHE333 |
site_id | SWS_FT_FI11 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:26416735 |
Chain | Residue | Details |
A | ASN342-LEU362 | |
B | ASN342-LEU362 |
site_id | SWS_FT_FI12 |
Number of Residues | 44 |
Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:26416735 |
Chain | Residue | Details |
A | MET371-ILE393 | |
B | MET371-ILE393 |
site_id | SWS_FT_FI13 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:26416735 |
Chain | Residue | Details |
A | MET412-ILE432 | |
B | MET412-ILE432 |
site_id | SWS_FT_FI14 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:26416735 |
Chain | Residue | Details |
A | TYR439-VAL459 | |
B | TYR439-VAL459 |
site_id | SWS_FT_FI15 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:26416735 |
Chain | Residue | Details |
A | TYR31 | |
B | ILE295 | |
B | HIS386 | |
B | HIS418 | |
A | GLN166 | |
A | GLN287 | |
A | ILE295 | |
A | HIS386 | |
A | HIS418 | |
B | TYR31 | |
B | GLN166 | |
B | GLN287 |
site_id | SWS_FT_FI16 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P22732 |
Chain | Residue | Details |
A | MET1 | |
B | MET1 |
site_id | SWS_FT_FI17 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | TYR50 | |
B | TYR50 |