4YBQ

Rat GLUT5 with Fv in the outward-open form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003044	biological_process	regulation of systemic arterial blood pressure mediated by a chemical signal
A	0005353	molecular_function	fructose transmembrane transporter activity
A	0005355	molecular_function	glucose transmembrane transporter activity
A	0005886	cellular_component	plasma membrane
A	0009750	biological_process	response to fructose
A	0015149	molecular_function	hexose transmembrane transporter activity
A	0015755	biological_process	fructose transmembrane transport
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0042383	cellular_component	sarcolemma
A	0055085	biological_process	transmembrane transport
A	0070061	molecular_function	fructose binding
A	0071332	biological_process	cellular response to fructose stimulus
A	0072237	biological_process	metanephric proximal tubule development
A	1904659	biological_process	glucose transmembrane transport
A	1990539	biological_process	fructose import across plasma membrane
B	0003044	biological_process	regulation of systemic arterial blood pressure mediated by a chemical signal
B	0005353	molecular_function	fructose transmembrane transporter activity
B	0005355	molecular_function	glucose transmembrane transporter activity
B	0005886	cellular_component	plasma membrane
B	0009750	biological_process	response to fructose
B	0015149	molecular_function	hexose transmembrane transporter activity
B	0015755	biological_process	fructose transmembrane transport
B	0016020	cellular_component	membrane
B	0016324	cellular_component	apical plasma membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0042383	cellular_component	sarcolemma
B	0055085	biological_process	transmembrane transport
B	0070061	molecular_function	fructose binding
B	0071332	biological_process	cellular response to fructose stimulus
B	0072237	biological_process	metanephric proximal tubule development
B	1904659	biological_process	glucose transmembrane transport
B	1990539	biological_process	fructose import across plasma membrane

Functional Information from PROSITE/UniProt

site_id	PS00216
Number of Residues	17
Details	SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. TVFVVELWGRRnllli.G

Chain	Residue	Details
A	THR331-GLY347

---

site_id	PS00217
Number of Residues	26
Details	SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. LvGICaGIssnvvpmYlgElapknlR

Chain	Residue	Details
A	LEU133-ARG158

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	324
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26416735

Chain	Residue	Details
A	MET1-ALA17
B	LEU149-ALA160
B	PRO213-GLN276
B	VAL334-ARG341
B	PRO394-TYR411
B	PRO460-GLN502
A	LEU91-ARG97
A	LEU149-ALA160
A	PRO213-GLN276
A	VAL334-ARG341
A	PRO394-TYR411
A	PRO460-GLN502
B	MET1-ALA17
B	LEU91-ARG97

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:26416735

Chain	Residue	Details
A	LEU18-VAL38
B	LEU18-VAL38

---

site_id	SWS_FT_FI3
Number of Residues	138
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:26416735

Chain	Residue	Details
A	ASN39-THR67
B	TYR298-ASP312
B	ALA363-TRP370
B	GLN433-PRO438
A	LYS119-GLU125
A	ARG182-TRP191
A	TYR298-ASP312
A	ALA363-TRP370
A	GLN433-PRO438
B	ASN39-THR67
B	LYS119-GLU125
B	ARG182-TRP191

---

site_id	SWS_FT_FI4
Number of Residues	44
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:26416735

Chain	Residue	Details
A	LEU68-PHE90
B	LEU68-PHE90

---

site_id	SWS_FT_FI5
Number of Residues	40
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:26416735

Chain	Residue	Details
A	LYS98-SER118
B	LYS98-SER118

---

site_id	SWS_FT_FI6
Number of Residues	44
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:26416735

Chain	Residue	Details
A	ILE126-TYR148
B	ILE126-TYR148

---

site_id	SWS_FT_FI7
Number of Residues	40
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:26416735

Chain	Residue	Details
A	LEU161-LEU181
B	LEU161-LEU181

---

site_id	SWS_FT_FI8
Number of Residues	40
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:26416735

Chain	Residue	Details
A	PRO192-PHE212
B	PRO192-PHE212

---

site_id	SWS_FT_FI9
Number of Residues	40
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:26416735

Chain	Residue	Details
A	LEU277-TYR297
B	LEU277-TYR297

---

site_id	SWS_FT_FI10
Number of Residues	40
Details	TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:26416735

Chain	Residue	Details
A	VAL313-PHE333
B	VAL313-PHE333

---

site_id	SWS_FT_FI11
Number of Residues	40
Details	TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:26416735

Chain	Residue	Details
A	ASN342-LEU362
B	ASN342-LEU362

---

site_id	SWS_FT_FI12
Number of Residues	44
Details	TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:26416735

Chain	Residue	Details
A	MET371-ILE393
B	MET371-ILE393

---

site_id	SWS_FT_FI13
Number of Residues	40
Details	TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:26416735

Chain	Residue	Details
A	MET412-ILE432
B	MET412-ILE432

---

site_id	SWS_FT_FI14
Number of Residues	40
Details	TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:26416735

Chain	Residue	Details
A	TYR439-VAL459
B	TYR439-VAL459

---

site_id	SWS_FT_FI15
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:26416735

Chain	Residue	Details
A	TYR31
B	ILE295
B	HIS386
B	HIS418
A	GLN166
A	GLN287
A	ILE295
A	HIS386
A	HIS418
B	TYR31
B	GLN166
B	GLN287

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P22732

Chain	Residue	Details
A	MET1
B	MET1

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	TYR50
B	TYR50

---