4YB9
Crystal structure of the Bovine Fructose transporter GLUT5 in an open inward-facing conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| D | 0003044 | biological_process | regulation of systemic arterial blood pressure mediated by a chemical signal |
| D | 0005353 | molecular_function | fructose transmembrane transporter activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0009750 | biological_process | response to fructose |
| D | 0015149 | molecular_function | hexose transmembrane transporter activity |
| D | 0015755 | biological_process | fructose transmembrane transport |
| D | 0016020 | cellular_component | membrane |
| D | 0016324 | cellular_component | apical plasma membrane |
| D | 0022857 | molecular_function | transmembrane transporter activity |
| D | 0042383 | cellular_component | sarcolemma |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0070061 | molecular_function | fructose binding |
| D | 0071332 | biological_process | cellular response to fructose stimulus |
| D | 0071702 | biological_process | organic substance transport |
| D | 1990539 | biological_process | fructose import across plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00216 |
| Number of Residues | 17 |
| Details | SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. AIFVVELMGRRfllll.G |
| Chain | Residue | Details |
| D | ALA332-GLY348 |
| site_id | PS00217 |
| Number of Residues | 26 |
| Details | SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. LvGICaGLssnvvpmYlgElapknwR |
| Chain | Residue | Details |
| D | LEU134-ARG159 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 121 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26416735 |
| Chain | Residue | Details |
| D | MET1-VAL18 | |
| D | LEU92-ARG98 | |
| D | LEU150-ALA161 | |
| D | PRO214-GLN277 | |
| D | VAL335-ARG342 | |
| D | PRO395-TYR412 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:26416735 |
| Chain | Residue | Details |
| D | LEU19-ILE39 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 69 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:26416735 |
| Chain | Residue | Details |
| D | ASN40-THR68 | |
| D | GLU120-GLU126 | |
| D | ARG183-TRP192 | |
| D | TYR299-ASP313 | |
| D | ALA364-TRP371 | |
| D | GLN434-ALA439 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:26416735 |
| Chain | Residue | Details |
| D | LEU69-PRO91 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:26416735 |
| Chain | Residue | Details |
| D | LYS99-SER119 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:26416735 |
| Chain | Residue | Details |
| D | MET127-TYR149 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:26416735 |
| Chain | Residue | Details |
| D | LEU162-LEU182 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:26416735 |
| Chain | Residue | Details |
| D | PRO193-PHE213 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:26416735 |
| Chain | Residue | Details |
| D | VAL278-TYR298 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:26416735 |
| Chain | Residue | Details |
| D | VAL314-PHE334 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:26416735 |
| Chain | Residue | Details |
| D | PHE343-LEU363 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:26416735 |
| Chain | Residue | Details |
| D | MET372-ILE394 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:26416735 |
| Chain | Residue | Details |
| D | MET413-ILE433 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:26416735 |
| Chain | Residue | Details |
| D | TYR440-ILE460 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P43427 |
| Chain | Residue | Details |
| D | TYR32 | |
| D | GLN167 | |
| D | GLN288 | |
| D | ILE296 | |
| D | HIS387 | |
| D | HIS419 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P22732 |
| Chain | Residue | Details |
| D | MET1 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| D | ALA51 |
