4Y97
Crystal Structure of human Pol alpha B-subunit in complex with C-terminal domain of catalytic subunit
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003674 | molecular_function | molecular_function |
| A | 0003677 | molecular_function | DNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005658 | cellular_component | alpha DNA polymerase:primase complex |
| A | 0005829 | cellular_component | cytosol |
| A | 0006260 | biological_process | DNA replication |
| A | 0006269 | biological_process | DNA replication, synthesis of primer |
| A | 0006270 | biological_process | DNA replication initiation |
| A | 0006606 | biological_process | protein import into nucleus |
| B | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| B | 0006260 | biological_process | DNA replication |
| C | 0003674 | molecular_function | molecular_function |
| C | 0003677 | molecular_function | DNA binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005658 | cellular_component | alpha DNA polymerase:primase complex |
| C | 0005829 | cellular_component | cytosol |
| C | 0006260 | biological_process | DNA replication |
| C | 0006269 | biological_process | DNA replication, synthesis of primer |
| C | 0006270 | biological_process | DNA replication initiation |
| C | 0006606 | biological_process | protein import into nucleus |
| D | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| D | 0006260 | biological_process | DNA replication |
| E | 0003674 | molecular_function | molecular_function |
| E | 0003677 | molecular_function | DNA binding |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005654 | cellular_component | nucleoplasm |
| E | 0005658 | cellular_component | alpha DNA polymerase:primase complex |
| E | 0005829 | cellular_component | cytosol |
| E | 0006260 | biological_process | DNA replication |
| E | 0006269 | biological_process | DNA replication, synthesis of primer |
| E | 0006270 | biological_process | DNA replication initiation |
| E | 0006606 | biological_process | protein import into nucleus |
| F | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| F | 0006260 | biological_process | DNA replication |
| G | 0003674 | molecular_function | molecular_function |
| G | 0003677 | molecular_function | DNA binding |
| G | 0005515 | molecular_function | protein binding |
| G | 0005634 | cellular_component | nucleus |
| G | 0005654 | cellular_component | nucleoplasm |
| G | 0005658 | cellular_component | alpha DNA polymerase:primase complex |
| G | 0005829 | cellular_component | cytosol |
| G | 0006260 | biological_process | DNA replication |
| G | 0006269 | biological_process | DNA replication, synthesis of primer |
| G | 0006270 | biological_process | DNA replication initiation |
| G | 0006606 | biological_process | protein import into nucleus |
| H | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| H | 0006260 | biological_process | DNA replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1501 |
| Chain | Residue |
| B | CYS1283 |
| B | CYS1286 |
| B | CYS1310 |
| B | CYS1315 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1502 |
| Chain | Residue |
| B | CYS1348 |
| B | CYS1353 |
| B | CYS1371 |
| B | CYS1374 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 1501 |
| Chain | Residue |
| D | CYS1286 |
| D | CYS1310 |
| D | CYS1315 |
| D | CYS1283 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 1502 |
| Chain | Residue |
| D | CYS1348 |
| D | CYS1353 |
| D | CYS1371 |
| D | CYS1374 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 1501 |
| Chain | Residue |
| F | CYS1283 |
| F | CYS1286 |
| F | CYS1310 |
| F | CYS1315 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 1502 |
| Chain | Residue |
| F | CYS1348 |
| F | CYS1353 |
| F | CYS1371 |
| F | CYS1374 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN H 1501 |
| Chain | Residue |
| H | CYS1283 |
| H | CYS1286 |
| H | CYS1310 |
| H | CYS1315 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN H 1502 |
| Chain | Residue |
| H | CYS1348 |
| H | CYS1353 |
| H | CYS1371 |
| H | CYS1374 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 140 |
| Details | ZN_FING: CysA-type => ECO:0000250|UniProtKB:P15436 |
| Chain | Residue | Details |
| B | CYS1283-SER1318 | |
| D | CYS1283-SER1318 | |
| F | CYS1283-SER1318 | |
| H | CYS1283-SER1318 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26975377, ECO:0007744|PDB:5EXR |
| Chain | Residue | Details |
| B | CYS1283 | |
| D | CYS1286 | |
| D | CYS1310 | |
| D | CYS1315 | |
| D | CYS1348 | |
| D | CYS1353 | |
| D | CYS1371 | |
| D | CYS1374 | |
| F | CYS1283 | |
| F | CYS1286 | |
| F | CYS1310 | |
| B | CYS1286 | |
| F | CYS1315 | |
| F | CYS1348 | |
| F | CYS1353 | |
| F | CYS1371 | |
| F | CYS1374 | |
| H | CYS1283 | |
| H | CYS1286 | |
| H | CYS1310 | |
| H | CYS1315 | |
| H | CYS1348 | |
| B | CYS1310 | |
| H | CYS1353 | |
| H | CYS1371 | |
| H | CYS1374 | |
| B | CYS1315 | |
| B | CYS1348 | |
| B | CYS1353 | |
| B | CYS1371 | |
| B | CYS1374 | |
| D | CYS1283 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER141 | |
| C | SER141 | |
| E | SER141 | |
| G | SER141 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER147 | |
| C | SER147 | |
| E | SER147 | |
| G | SER147 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER152 | |
| C | SER152 | |
| E | SER152 | |
| G | SER152 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER154 | |
| C | SER154 | |
| E | SER154 | |
| G | SER154 |
