4Y83

Crystal structure of COT kinase domain in complex with 5-(2-amino-5-(quinolin-3-yl)pyridin-3-yl)-1,3,4-oxadiazole-2(3H)-thione

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 49B A 401

Chain	Residue
A	TRP132
A	GLY213
A	SER214
A	GLU217
A	VAL260
A	ASP270
A	ILE144
A	ARG146
A	VAL152
A	ALA165
A	LYS167
A	MET207
A	GLU208
A	GLY210

---

site_id	AC2
Number of Residues	15
Details	binding site for residue 49B B 401

Chain	Residue
B	TRP132
B	LEU134
B	ILE144
B	ARG146
B	ALA165
B	LYS167
B	MET207
B	GLU208
B	GLY210
B	GLY213
B	SER214
B	GLU217
B	VAL260
B	VAL269
B	HOH511

---

site_id	AC3
Number of Residues	11
Details	binding site for residue 49B C 401

Chain	Residue
C	TRP132
C	ILE144
C	ARG146
C	VAL152
C	ALA165
C	MET207
C	GLU208
C	GLY210
C	GLY213
C	VAL269
C	ASP270

---

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHhDIKpsNIVF

Chain	Residue	Details
A	VAL249-PHE261

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP253
B	ASP253
C	ASP253

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE144
A	LYS167
B	ILE144
B	LYS167
C	ILE144
C	LYS167

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:17472361

Chain	Residue	Details
A	THR80
B	THR80
C	THR80

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER141
B	SER141
C	SER141

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:15466476, ECO:0000269|PubMed:15699325

Chain	Residue	Details
A	THR290
B	THR290
C	THR290

---