4Y5V

Diabody 305 complex with EpoR

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004896	molecular_function	cytokine receptor activity
C	0016020	cellular_component	membrane
F	0004896	molecular_function	cytokine receptor activity
F	0016020	cellular_component	membrane
I	0004896	molecular_function	cytokine receptor activity
I	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue GOL A 201

Chain	Residue
A	SER106
A	ASP107
A	TRP108
A	HOH301
B	PRO46
B	LYS47

---

site_id	AC2
Number of Residues	5
Details	binding site for residue GOL B 201

Chain	Residue
B	LYS44
B	HOH302
B	GLN40
B	HIS41
B	GLY43

---

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL B 202

Chain	Residue
B	ASP52
B	ARG55
C	GLU34
C	THR87
C	THR90

---

site_id	AC4
Number of Residues	7
Details	binding site for residue GOL B 203

Chain	Residue
A	GLY42
A	LYS43
A	GLY44
B	ASP87
B	TYR89
B	GLY103
B	GLY104

---

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL D 201

Chain	Residue
D	ASP54
D	ARG72
D	ASP73
D	ASN74
D	GOL202
D	HOH331

---

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL D 202

Chain	Residue
D	ILE51
D	LYS58
D	SER71
D	ARG72
D	GOL201

---

site_id	AC7
Number of Residues	7
Details	binding site for residue PGE D 203

Chain	Residue
D	SER56
D	GLU57
D	LYS58
D	TYR60
D	THR69
G	LEU11
G	SER118

---

site_id	AC8
Number of Residues	4
Details	binding site for residue PEG D 204

Chain	Residue
A	SER71
A	ARG72
D	LEU113
D	THR115

---

site_id	AC9
Number of Residues	5
Details	binding site for residue GOL E 201

Chain	Residue
D	GLN39
D	GLY42
E	GLN40
E	GLY43
E	LYS44

---

site_id	AD1
Number of Residues	6
Details	binding site for residue GOL E 202

Chain	Residue
E	ILE33
E	ASP52
E	ARG55
F	THR87
F	THR90
F	SER91

---

site_id	AD2
Number of Residues	5
Details	binding site for residue GOL E 203

Chain	Residue
D	GLY42
E	TYR89
E	GLY103
E	GLY104
E	THR105

---

site_id	AD3
Number of Residues	5
Details	binding site for residue GOL F 301

Chain	Residue
C	TRP212
C	SER213
C	GLU214
F	ARG191
F	SER217

---

site_id	AD4
Number of Residues	7
Details	binding site for residue GOL G 201

Chain	Residue
A	GLN13
D	ARG87
G	LYS65
G	GLY66
G	PHE68
G	THR69
G	HOH314

---

site_id	AD5
Number of Residues	4
Details	binding site for residue GOL G 202

Chain	Residue
A	GLY120
G	SER56
G	GLU57
G	LYS58

---

site_id	AD6
Number of Residues	6
Details	binding site for residue GOL H 201

Chain	Residue
G	GLY42
G	TYR95
G	HOH315
H	GLN40
H	GLY43
H	LYS44

---

site_id	AD7
Number of Residues	5
Details	binding site for residue GOL H 202

Chain	Residue
G	GLY42
H	TYR89
H	GLY103
H	GLY104
H	THR105

---

site_id	AD8
Number of Residues	3
Details	binding site for residue GOL H 203

Chain	Residue
G	TRP108
H	ALA45
H	PRO46

---

Functional Information from PROSITE/UniProt

site_id	PS01352
Number of Residues	81
Details	HEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. VvLrWlpppetpmtshir...YEVdvsagqgagsvqrveilegrtecvlsnLrgrtrytfavRaRmaepsfggfWsaWsepvsL

Chain	Residue	Details
C	VAL138-LEU218

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Motif: {"description":"WSXWS motif","evidences":[{"source":"PubMed","id":"9774108","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Site: {"description":"Required for ligand binding","evidences":[{"source":"PubMed","id":"8662939","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---