4Y49

Crystal structure of yeast N-terminal acetyltransferase (ppGpp) NatE in complex with a bisubstrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0006474	biological_process	N-terminal protein amino acid acetylation
A	0010698	molecular_function	acetyltransferase activator activity
A	0031415	cellular_component	NatA complex
A	0043022	molecular_function	ribosome binding
B	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006474	biological_process	N-terminal protein amino acid acetylation
B	0008999	molecular_function	protein-N-terminal-alanine acetyltransferase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0031415	cellular_component	NatA complex
B	0042802	molecular_function	identical protein binding
B	0061606	biological_process	N-terminal protein amino acid propionylation
B	1990189	molecular_function	protein N-terminal-serine acetyltransferase activity
B	1990190	molecular_function	protein-N-terminal-glutamate acetyltransferase activity
C	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006474	biological_process	N-terminal protein amino acid acetylation
C	0007064	biological_process	mitotic sister chromatid cohesion
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0031415	cellular_component	NatA complex
C	0061733	molecular_function	protein-lysine-acetyltransferase activity
C	0120518	molecular_function	protein N-terminal-methionine acetyltransferase activity
G	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0006474	biological_process	N-terminal protein amino acid acetylation
G	0010698	molecular_function	acetyltransferase activator activity
G	0031415	cellular_component	NatA complex
G	0043022	molecular_function	ribosome binding
H	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0006474	biological_process	N-terminal protein amino acid acetylation
H	0008999	molecular_function	protein-N-terminal-alanine acetyltransferase activity
H	0016740	molecular_function	transferase activity
H	0016746	molecular_function	acyltransferase activity
H	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
H	0031415	cellular_component	NatA complex
H	0042802	molecular_function	identical protein binding
H	0061606	biological_process	N-terminal protein amino acid propionylation
H	1990189	molecular_function	protein N-terminal-serine acetyltransferase activity
H	1990190	molecular_function	protein-N-terminal-glutamate acetyltransferase activity
I	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0006474	biological_process	N-terminal protein amino acid acetylation
I	0007064	biological_process	mitotic sister chromatid cohesion
I	0016740	molecular_function	transferase activity
I	0016746	molecular_function	acyltransferase activity
I	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
I	0031415	cellular_component	NatA complex
I	0061733	molecular_function	protein-lysine-acetyltransferase activity
I	0120518	molecular_function	protein N-terminal-methionine acetyltransferase activity
M	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0006474	biological_process	N-terminal protein amino acid acetylation
M	0010698	molecular_function	acetyltransferase activator activity
M	0031415	cellular_component	NatA complex
M	0043022	molecular_function	ribosome binding
N	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0006474	biological_process	N-terminal protein amino acid acetylation
N	0008999	molecular_function	protein-N-terminal-alanine acetyltransferase activity
N	0016740	molecular_function	transferase activity
N	0016746	molecular_function	acyltransferase activity
N	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
N	0031415	cellular_component	NatA complex
N	0042802	molecular_function	identical protein binding
N	0061606	biological_process	N-terminal protein amino acid propionylation
N	1990189	molecular_function	protein N-terminal-serine acetyltransferase activity
N	1990190	molecular_function	protein-N-terminal-glutamate acetyltransferase activity
O	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0006474	biological_process	N-terminal protein amino acid acetylation
O	0007064	biological_process	mitotic sister chromatid cohesion
O	0016740	molecular_function	transferase activity
O	0016746	molecular_function	acyltransferase activity
O	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
O	0031415	cellular_component	NatA complex
O	0061733	molecular_function	protein-lysine-acetyltransferase activity
O	0120518	molecular_function	protein N-terminal-methionine acetyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue G4P A 901

Chain	Residue
A	ARG437
A	LYS468

---

site_id	AC2
Number of Residues	13
Details	binding site for residue ACO C 201

Chain	Residue
C	LYS105
C	SER106
C	GLY108
C	SER109
C	TRP141
M	GLN331
C	THR26
C	GLU94
C	PHE95
C	LEU96
C	VAL98
C	ARG103
C	HIS104

---

site_id	AC3
Number of Residues	3
Details	binding site for residue G4P G 901

Chain	Residue
G	LEU406
G	ARG437
H	HIS22

---

site_id	AC4
Number of Residues	14
Details	binding site for residue ACO I 201

Chain	Residue
I	THR26
I	VAL27
I	ILE93
I	GLU94
I	PHE95
I	LEU96
I	VAL98
I	ARG103
I	HIS104
I	LYS105
I	SER106
I	GLY108
I	SER109
I	TRP141

---

site_id	AC5
Number of Residues	3
Details	binding site for residue G4P M 901

Chain	Residue
M	LYS360
M	LEU406
M	ARG437

---

site_id	AC6
Number of Residues	13
Details	binding site for residue ACO O 201

Chain	Residue
O	THR26
O	ILE93
O	GLU94
O	PHE95
O	LEU96
O	GLY97
O	VAL98
O	HIS104
O	LYS105
O	SER106
O	GLY108
O	SER109
O	TRP141

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	99
Details	Repeat: {"description":"TPR 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	108
Details	Repeat: {"description":"TPR 4"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	99
Details	Repeat: {"description":"TPR 5"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	99
Details	Repeat: {"description":"TPR 6"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"N-acetylserine; in Corticotropin","evidences":[{"source":"UniProtKB","id":"P01191","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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