4Y1P
Crystal structure of 3-isopropylmalate dehydrogenase (Saci_0600) from Sulfolobus acidocaldarius complex with 3-isopropylmalate and Mg2+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
| A | 0004449 | molecular_function | isocitrate dehydrogenase (NAD+) activity |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006102 | biological_process | isocitrate metabolic process |
| A | 0009098 | biological_process | L-leucine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
| B | 0004449 | molecular_function | isocitrate dehydrogenase (NAD+) activity |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006102 | biological_process | isocitrate metabolic process |
| B | 0009098 | biological_process | L-leucine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 401 |
| Chain | Residue |
| A | ASP201 |
| A | ASP225 |
| A | ASP229 |
| A | IPM402 |
| A | HOH501 |
| A | HOH522 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue IPM A 402 |
| Chain | Residue |
| A | ARG117 |
| A | TYR124 |
| A | LYS170 |
| A | VAL173 |
| A | ASP201 |
| A | ASP225 |
| A | MG401 |
| A | HOH501 |
| A | HOH520 |
| A | HOH522 |
| A | HOH595 |
| A | ALA78 |
| A | ARG86 |
| A | ARG96 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | ASP291 |
| A | ILE292 |
| A | ARG293 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | GLU197 |
| A | MET198 |
| A | TYR199 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 405 |
| Chain | Residue |
| A | ARG160 |
| B | LYS163 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 401 |
| Chain | Residue |
| B | ASP201 |
| B | ASP225 |
| B | IPM402 |
| B | HOH503 |
| B | HOH524 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue IPM B 402 |
| Chain | Residue |
| B | ARG86 |
| B | ARG96 |
| B | ARG117 |
| B | TYR124 |
| B | LYS170 |
| B | VAL173 |
| B | ASP201 |
| B | ASP225 |
| B | MG401 |
| B | HOH503 |
| B | HOH524 |
Functional Information from PROSITE/UniProt
| site_id | PS00470 |
| Number of Residues | 20 |
| Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NTYGDIlSDeaGqia.GSLGI |
| Chain | Residue | Details |
| A | ASN221-ILE240 |
