4Y1H

Crystal structure of K33 linked tri-Ubiquitin

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue EDO A 101

Chain	Residue
A	PHE4
A	LYS6
A	THR12
A	GLU18
A	PRO19
A	SER20
A	GLN31
A	THR66

---

site_id	AC2
Number of Residues	9
Details	binding site for residue EDO A 102

Chain	Residue
A	ASP32
A	GLY35
A	PHE45
A	ALA46
A	GLY47
A	THR66
A	HIS68
A	HOH217
A	GLN31

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 103

Chain	Residue
A	THR7
A	LEU8
A	THR9
A	LEU69
A	LEU71

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 104

Chain	Residue
A	SER20
A	ASP39
A	GLN40
A	GLU64
A	ARG74

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
A	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
A	ARG54
A	ARG72

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Essential for function

Chain	Residue	Details
A	HIS68

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P62979

Chain	Residue	Details
A	SER65

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: ADP-ribosylglycine => ECO:0000250|UniProtKB:P62979

Chain	Residue	Details
A	GLY76

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62979

Chain	Residue	Details
A	LYS6
A	LYS11
A	LYS27
A	LYS29
A	LYS33
A	LYS48
A	LYS63

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
A	GLY76

---