4Y12

Crystal structure of the S/T protein kinase PknG from Mycobacterium tuberculosis in complex with AGS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue AGS A 501

Chain	Residue
A	ARG83
A	TYR234
A	VAL235
A	ASN281
A	ASP293
A	MG503
A	MG504
A	HOH602
A	HOH608
A	HOH667
A	HOH676
A	ASP86
A	HOH687
A	HOH693
A	GLY160
A	GLY161
A	LEU162
A	VAL179
A	LYS181
A	MET232
A	GLU233

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 502

Chain	Residue
A	CYS106
A	CYS109
A	CYS128
A	CYS131

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 503

Chain	Residue
A	ASN281
A	ASP293
A	AGS501
A	HOH607
A	HOH628

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MG A 504

Chain	Residue
A	ASP293
A	AGS501
A	HOH602
A	HOH612
A	HOH629
A	HOH693

---

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LvYnDLKpeNIML

Chain	Residue	Details
A	LEU272-LEU284

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	245
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---