Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4Y08

ONE MINUTE IRON LOADED HUMAN H FERRITIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005776	cellular_component	autophagosome
A	0005829	cellular_component	cytosol
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006880	biological_process	intracellular sequestering of iron ion
A	0006955	biological_process	immune response
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0031410	cellular_component	cytoplasmic vesicle
A	0042802	molecular_function	identical protein binding
A	0044754	cellular_component	autolysosome
A	0046872	molecular_function	metal ion binding
A	0048147	biological_process	negative regulation of fibroblast proliferation
A	0070062	cellular_component	extracellular exosome
A	0070288	cellular_component	ferritin complex
A	0110076	biological_process	negative regulation of ferroptosis
A	0140315	molecular_function	iron ion sequestering activity
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue FE2 A 201

Chain	Residue
A	GLU27
A	GLU62
A	HIS65
A	FE2202
A	OXY219
A	HOH611
A	HOH625
A	HOH627

site_id	AC2
Number of Residues	9
Details	binding site for residue FE2 A 202

Chain	Residue
A	GLU107
A	GLN141
A	FE2201
A	FE2203
A	OXY219
A	OXY220
A	HOH625
A	HOH627
A	GLU62

site_id	AC3
Number of Residues	10
Details	binding site for residue FE2 A 203

Chain	Residue
A	GLN58
A	GLU62
A	GLU107
A	FE2202
A	OXY219
A	OXY220
A	HOH619
A	HOH620
A	HOH621
A	HOH622

site_id	AC4
Number of Residues	12
Details	binding site for residue FE2 A 204

Chain	Residue
A	HIS173
A	HIS173
A	HIS173
A	HIS173
A	CL208
A	CL208
A	CL208
A	CL208
A	CL210
A	CL210
A	CL210
A	CL210

site_id	AC5
Number of Residues	3
Details	binding site for residue CL A 205

Chain	Residue
A	GLN75
A	ASN139
A	HOH394

site_id	AC6
Number of Residues	4
Details	binding site for residue CL A 206

Chain	Residue
A	GLN83
A	ASP84
A	LYS86
A	HOH424

site_id	AC7
Number of Residues	3
Details	binding site for residue CL A 207

Chain	Residue
A	GLN14
A	HOH539
A	HOH570

site_id	AC8
Number of Residues	8
Details	binding site for residue CL A 208

Chain	Residue
A	HIS173
A	HIS173
A	HIS173
A	HIS173
A	FE2204
A	FE2204
A	FE2204
A	FE2204

site_id	AC9
Number of Residues	5
Details	binding site for residue CL A 209

Chain	Residue
A	ARG9
A	ASN11
A	TYR12
A	HOH400
A	HOH529

site_id	AD1
Number of Residues	8
Details	binding site for residue CL A 210

Chain	Residue
A	HIS173
A	HIS173
A	HIS173
A	HIS173
A	FE2204
A	FE2204
A	FE2204
A	FE2204

site_id	AD2
Number of Residues	4
Details	binding site for residue CL A 211

Chain	Residue
A	ASN25
A	HOH512
A	HOH553
A	HOH603

site_id	AD3
Number of Residues	4
Details	binding site for residue CL A 212

Chain	Residue
A	GLN75
A	HOH342
A	HOH381
A	HOH522

site_id	AD4
Number of Residues	4
Details	binding site for residue CL A 213

Chain	Residue
A	ASN125
A	HOH353
A	HOH360
A	HOH433

site_id	AD5
Number of Residues	8
Details	binding site for residue MG A 214

Chain	Residue
A	HOH307
A	HOH307
A	HOH319
A	HOH319
A	HOH424
A	HOH424
A	HOH442
A	HOH442

site_id	AD6
Number of Residues	6
Details	binding site for residue MG A 215

Chain	Residue
A	HOH320
A	HOH320
A	HOH320
A	HOH406
A	HOH406
A	HOH406

site_id	AD7
Number of Residues	6
Details	binding site for residue MG A 216

Chain	Residue
A	HOH383
A	HOH418
A	HOH434
A	HOH351
A	HOH361
A	HOH363

site_id	AD8
Number of Residues	12
Details	binding site for residue MG A 217

Chain	Residue
A	ASP131
A	ASP131
A	ASP131
A	HOH301
A	HOH301
A	HOH301
A	HOH311
A	HOH311
A	HOH311
A	HOH427
A	HOH427
A	HOH427

site_id	AD9
Number of Residues	6
Details	binding site for residue MG A 218

Chain	Residue
A	HOH456
A	HOH486
A	HOH564
A	HOH603
A	HOH604
A	HOH608

site_id	AE1
Number of Residues	12
Details	binding site for residue OXY A 219

Chain	Residue
A	GLU62
A	HIS65
A	GLU107
A	VAL110
A	GLN141
A	FE2201
A	FE2202
A	FE2203
A	OXY220
A	HOH611
A	HOH625
A	HOH627

site_id	AE2
Number of Residues	11
Details	binding site for residue OXY A 220

Chain	Residue
A	GLU62
A	HIS65
A	GLU107
A	GLU140
A	GLN141
A	ALA144
A	FE2202
A	FE2203
A	OXY219
A	HOH619
A	HOH621

site_id	AE3
Number of Residues	2
Details	binding site for residue FE2 A 221

Chain	Residue
A	HIS57
A	GLU61

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFIEthYLneqvkaIK

Chain	Residue	Details
A	ASP126-LYS146

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EeREhaEKLMklQNqRgGR

Chain	Residue	Details
A	GLU61-ARG79

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:1992356, ECO:0007744\|PDB:1FHA

Chain	Residue	Details
A	GLU27
A	HIS65

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00085

Chain	Residue	Details
A	GLU62
A	GLU107
A	GLN141

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Essential for association with cargo receptor NCOA4 => ECO:0000269\|PubMed:26436293

Chain	Residue	Details
A	ARG22

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744\|PubMed:22814378

Chain	Residue	Details
A	MET0

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N-acetylthreonine; in Ferritin heavy chain, N-terminally processed => ECO:0007744\|PubMed:22814378

Chain	Residue	Details
A	THR1

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:18318008, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER178

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18318008

Chain	Residue	Details
A	SER182

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)