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4XXO

Crystal Structure of Human APOBEC3A

Functional Information from GO Data
ChainGOidnamespacecontents
A0000932cellular_componentP-body
A0003723molecular_functionRNA binding
A0003824molecular_functioncatalytic activity
A0004126molecular_functioncytidine deaminase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0010526biological_processretrotransposon silencing
A0016554biological_processcytidine to uridine editing
A0016787molecular_functionhydrolase activity
A0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
A0044355biological_processclearance of foreign intracellular DNA
A0045071biological_processnegative regulation of viral genome replication
A0045087biological_processinnate immune response
A0045869biological_processnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate
A0046872molecular_functionmetal ion binding
A0051607biological_processdefense response to virus
A0070383biological_processDNA cytosine deamination
B0000932cellular_componentP-body
B0003723molecular_functionRNA binding
B0003824molecular_functioncatalytic activity
B0004126molecular_functioncytidine deaminase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0010526biological_processretrotransposon silencing
B0016554biological_processcytidine to uridine editing
B0016787molecular_functionhydrolase activity
B0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
B0044355biological_processclearance of foreign intracellular DNA
B0045071biological_processnegative regulation of viral genome replication
B0045087biological_processinnate immune response
B0045869biological_processnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate
B0046872molecular_functionmetal ion binding
B0051607biological_processdefense response to virus
B0070383biological_processDNA cytosine deamination
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue ZN A 201
ChainResidue
ATHR31
AZN202
AHOH321

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN A 202
ChainResidue
AHIS70
ACYS101
ACYS106
AZN201

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN A 203
ChainResidue
BHIS182
BHOH331
AHIS29
ACL206

site_idAC4
Number of Residues5
Detailsbinding site for residue ZN A 204
ChainResidue
AHIS11
AHOH301
AHOH314
BHIS56
BCL203

site_idAC5
Number of Residues4
Detailsbinding site for residue ZN A 205
ChainResidue
AHIS56
AHOH316
BHIS11
BCL203

site_idAC6
Number of Residues2
Detailsbinding site for residue CL A 206
ChainResidue
ALYS30
AZN203

site_idAC7
Number of Residues4
Detailsbinding site for residue ZN B 201
ChainResidue
BHIS70
BCYS101
BCYS106
BZN202

site_idAC8
Number of Residues3
Detailsbinding site for residue ZN B 202
ChainResidue
BTHR31
BZN201
BHOH318

site_idAC9
Number of Residues5
Detailsbinding site for residue CL B 203
ChainResidue
AZN204
AZN205
AHOH301
AHOH307
BHOH307

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000250
ChainResidueDetails
AALA72
BALA72

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AHIS70
ACYS101
ACYS106
BHIS70
BCYS101
BCYS106

227344

PDB entries from 2024-11-13

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