4XXD

Crystal Structure of mid-region amyloid beta capture by solanezumab

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0002376	biological_process	immune system process
A	0003823	molecular_function	antigen binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0006955	biological_process	immune response
A	0016020	cellular_component	membrane
A	0016064	biological_process	immunoglobulin mediated immune response
A	0019814	cellular_component	immunoglobulin complex
A	0050853	biological_process	B cell receptor signaling pathway
A	0070062	cellular_component	extracellular exosome
A	0071735	cellular_component	IgG immunoglobulin complex
A	0071738	cellular_component	IgD immunoglobulin complex
A	0071742	cellular_component	IgE immunoglobulin complex
A	0071745	cellular_component	IgA immunoglobulin complex
A	0071753	cellular_component	IgM immunoglobulin complex
A	0072562	cellular_component	blood microparticle
C	0016020	cellular_component	membrane
D	0002250	biological_process	adaptive immune response
D	0002376	biological_process	immune system process
D	0003823	molecular_function	antigen binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005886	cellular_component	plasma membrane
D	0006955	biological_process	immune response
D	0016020	cellular_component	membrane
D	0016064	biological_process	immunoglobulin mediated immune response
D	0019814	cellular_component	immunoglobulin complex
D	0050853	biological_process	B cell receptor signaling pathway
D	0070062	cellular_component	extracellular exosome
D	0071735	cellular_component	IgG immunoglobulin complex
D	0071738	cellular_component	IgD immunoglobulin complex
D	0071742	cellular_component	IgE immunoglobulin complex
D	0071745	cellular_component	IgA immunoglobulin complex
D	0071753	cellular_component	IgM immunoglobulin complex
D	0072562	cellular_component	blood microparticle
F	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
B	TYR189-HIS195
A	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:10413512, ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943

Chain	Residue	Details
C	HIS13
F	HIS13

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943

Chain	Residue	Details
C	HIS14
F	HIS14

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430

Chain	Residue	Details
C	LYS16
F	LYS16

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112

Chain	Residue	Details
C	PHE19
F	PHE19

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