4XWG

Crystal Structure of LCAT (C31Y) in complex with Fab1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003847	molecular_function	1-alkyl-2-acetylglycerophosphocholine esterase activity
A	0004607	molecular_function	phosphatidylcholine-sterol O-acyltransferase activity
A	0004623	molecular_function	phospholipase A2 activity
A	0004771	molecular_function	sterol ester esterase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006629	biological_process	lipid metabolic process
A	0006644	biological_process	phospholipid metabolic process
A	0006656	biological_process	phosphatidylcholine biosynthetic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008374	molecular_function	O-acyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0030301	biological_process	cholesterol transport
A	0034186	molecular_function	apolipoprotein A-I binding
A	0034364	cellular_component	high-density lipoprotein particle
A	0034372	biological_process	very-low-density lipoprotein particle remodeling
A	0034375	biological_process	high-density lipoprotein particle remodeling
A	0034435	biological_process	obsolete cholesterol esterification
A	0042157	biological_process	lipoprotein metabolic process
A	0042158	biological_process	lipoprotein biosynthetic process
A	0042632	biological_process	cholesterol homeostasis
A	0043691	biological_process	reverse cholesterol transport
A	0046222	biological_process	aflatoxin metabolic process
A	0046470	biological_process	phosphatidylcholine metabolic process
A	0046688	biological_process	response to copper ion
A	0047179	molecular_function	platelet-activating factor acetyltransferase activity
A	0051384	biological_process	response to glucocorticoid
A	0070062	cellular_component	extracellular exosome
A	0090107	biological_process	regulation of high-density lipoprotein particle assembly

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VFLIGHSLGC

Chain	Residue	Details
A	VAL175-CYS184

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR207-HIS213
L	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000305|PubMed:26195816

Chain	Residue	Details
A	SER181

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Charge relay system => ECO:0000305|PubMed:26195816

Chain	Residue	Details
A	ASP345
A	HIS377

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Determinant for substrate specificity => ECO:0000305|PubMed:14636062

Chain	Residue	Details
A	GLU149

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:7613477

Chain	Residue	Details
A	ASN20

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:26195816, ECO:0000269|PubMed:7613477, ECO:0007744|PDB:4X96

Chain	Residue	Details
A	ASN84
A	ASN384

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:26195816, ECO:0000269|PubMed:7613477, ECO:0007744|PDB:4X96

Chain	Residue	Details
A	ASN272

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site_id	SWS_FT_FI7
Number of Residues	1
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:7613477

Chain	Residue	Details
A	THR407

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site_id	SWS_FT_FI8
Number of Residues	1
Details	CARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:7613477

Chain	Residue	Details
A	SER409

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