4XRH

Human DNA polymerase lambda- MgdTTP binary and complex with 6 paired DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity
B	0003677	molecular_function	DNA binding
B	0003887	molecular_function	DNA-directed DNA polymerase activity
B	0006281	biological_process	DNA repair
B	0016779	molecular_function	nucleotidyltransferase activity
B	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue MG A 601

Chain	Residue
A	ASP427
A	ASP429
A	TTP602

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site_id	AC2
Number of Residues	14
Details	binding site for residue TTP A 602

Chain	Residue
A	ASP429
A	TYR505
A	PHE506
A	THR507
A	GLY508
A	ALA510
A	ASN513
A	MG601
A	ARG386
A	GLY416
A	SER417
A	ARG420
A	GLY426
A	ASP427

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Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP

Chain	Residue	Details
B	GLY416-PRO435

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865

Chain	Residue	Details
B	LYS312
A	LYS312

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ

Chain	Residue	Details
B	ARG386
B	SER417
B	GLY426
B	ASN513
A	ARG386
A	SER417
A	GLY426
A	ASN513

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site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ

Chain	Residue	Details
B	ASP427
B	ASP429
B	ASP490
A	ASP427
A	ASP429
A	ASP490

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