4XQ6
CRYSTAL STRUCTURE OF DIHYDROOROTATE DEHYDROGENSE from MYCOBACTERIUM TUBERCULOSIS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0006222 | biological_process | UMP biosynthetic process |
| A | 0009220 | biological_process | pyrimidine ribonucleotide biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| A | 0106430 | molecular_function | dihydroorotate dehydrogenase (quinone) activity |
| B | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0006222 | biological_process | UMP biosynthetic process |
| B | 0009220 | biological_process | pyrimidine ribonucleotide biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0106430 | molecular_function | dihydroorotate dehydrogenase (quinone) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue FMN A 401 |
| Chain | Residue |
| A | ALA65 |
| A | THR240 |
| A | ASN241 |
| A | SER263 |
| A | GLY264 |
| A | LEU267 |
| A | VAL291 |
| A | GLY292 |
| A | GLY293 |
| A | GLY313 |
| A | TYR314 |
| A | ALA66 |
| A | THR315 |
| A | HOH536 |
| A | HOH570 |
| A | HOH603 |
| A | GLY67 |
| A | THR90 |
| A | ASN115 |
| A | ASN143 |
| A | ASN176 |
| A | SER179 |
| A | LYS212 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 402 |
| Chain | Residue |
| A | PHE119 |
| A | THR182 |
| A | HOH573 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 403 |
| Chain | Residue |
| A | ASN115 |
| A | THR242 |
| A | GLY261 |
| A | HOH601 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 401 |
| Chain | Residue |
| A | HIS94 |
| A | HOH513 |
| A | HOH521 |
| B | ASP227 |
| B | HOH506 |
| B | HOH528 |
| site_id | AC5 |
| Number of Residues | 23 |
| Details | binding site for residue FMN B 402 |
| Chain | Residue |
| B | ALA65 |
| B | ALA66 |
| B | GLY67 |
| B | THR90 |
| B | ASN115 |
| B | ASN143 |
| B | ASN176 |
| B | LYS212 |
| B | THR240 |
| B | ASN241 |
| B | SER263 |
| B | GLY264 |
| B | LEU267 |
| B | VAL291 |
| B | GLY292 |
| B | GLY293 |
| B | GLY313 |
| B | TYR314 |
| B | THR315 |
| B | HOH543 |
| B | HOH546 |
| B | HOH595 |
| B | HOH599 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue CL B 403 |
| Chain | Residue |
| B | ASN115 |
| B | PRO180 |
| B | THR242 |
| B | HOH593 |
| B | HOH596 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 404 |
| Chain | Residue |
| B | PHE119 |
| B | THR182 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 405 |
| Chain | Residue |
| B | ARG133 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000250 |
| Chain | Residue | Details |
| A | SER179 | |
| B | SER179 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 26 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ALA66 | |
| A | ASN241 | |
| A | GLY264 | |
| A | GLY293 | |
| A | TYR314 | |
| B | ALA66 | |
| B | LYS70 | |
| B | THR90 | |
| B | ASN115 | |
| B | ASN143 | |
| B | ASN176 | |
| A | LYS70 | |
| B | ASN181 | |
| B | LYS212 | |
| B | THR240 | |
| B | ASN241 | |
| B | GLY264 | |
| B | GLY293 | |
| B | TYR314 | |
| A | THR90 | |
| A | ASN115 | |
| A | ASN143 | |
| A | ASN176 | |
| A | ASN181 | |
| A | LYS212 | |
| A | THR240 |
