4XO5

Crystal Structure of E. coli Aminopeptidase N in complex with L-Glutamate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0016285	molecular_function	alanyl aminopeptidase activity
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 901

Chain	Residue
A	HIS297
A	HIS301
A	GLU320
A	GLU902

---

site_id	AC2
Number of Residues	17
Details	binding site for residue GLU A 902

Chain	Residue
A	GLU264
A	HIS297
A	GLU298
A	HIS301
A	LYS319
A	GLU320
A	TYR376
A	TYR381
A	ZN901
A	HOH1028
A	HOH1182
A	HOH1465
A	GLN119
A	GLU121
A	MET260
A	ALA262
A	MET263

---

site_id	AC3
Number of Residues	12
Details	binding site for residue GLU A 903

Chain	Residue
A	ALA638
A	ARG641
A	GLU642
A	ARG686
A	PHE690
A	ALA722
A	NA909
A	HOH1004
A	HOH1191
A	HOH1534
A	HOH1548
A	HOH1640

---

site_id	AC4
Number of Residues	6
Details	binding site for residue NA A 904

Chain	Residue
A	ASP452
A	NA906
A	GOL918
A	HOH1591
A	HOH1783
A	HOH1804

---

site_id	AC5
Number of Residues	6
Details	binding site for residue NA A 905

Chain	Residue
A	SER332
A	ASP333
A	GLY335
A	HOH1597
A	HOH1691
A	HOH1795

---

site_id	AC6
Number of Residues	7
Details	binding site for residue NA A 906

Chain	Residue
A	ASP452
A	TYR544
A	NA904
A	HOH1234
A	HOH1703
A	HOH1788
A	HOH1804

---

site_id	AC7
Number of Residues	6
Details	binding site for residue NA A 907

Chain	Residue
A	ILE23
A	ARG140
A	PHE141
A	THR142
A	HOH1082
A	HOH1758

---

site_id	AC8
Number of Residues	5
Details	binding site for residue NA A 908

Chain	Residue
A	GLU371
A	HOH1017
A	HOH1070
A	HOH1111
A	HOH1520

---

site_id	AC9
Number of Residues	3
Details	binding site for residue NA A 909

Chain	Residue
A	THR645
A	GLU903
A	HOH1627

---

site_id	AD1
Number of Residues	6
Details	binding site for residue NA A 910

Chain	Residue
A	ARG349
A	ASP566
A	SER570
A	GOL917
A	HOH1829
A	HOH1872

---

site_id	AD2
Number of Residues	5
Details	binding site for residue NA A 911

Chain	Residue
A	GLN19
A	ILE20
A	LEU138
A	HOH1634
A	HOH1831

---

site_id	AD3
Number of Residues	5
Details	binding site for residue NA A 912

Chain	Residue
A	GLU426
A	ASP432
A	SER434
A	HOH1265
A	HOH1780

---

site_id	AD4
Number of Residues	5
Details	binding site for residue NA A 913

Chain	Residue
A	HIS771
A	PHE774
A	HOH1271
A	HOH1467
A	HOH1702

---

site_id	AD5
Number of Residues	11
Details	binding site for residue GOL A 914

Chain	Residue
A	SER63
A	VAL64
A	TRP71
A	TRP74
A	ARG669
A	VAL670
A	GLU671
A	GOL916
A	GOL919
A	HOH1142
A	HOH1267

---

site_id	AD6
Number of Residues	5
Details	binding site for residue GOL A 915

Chain	Residue
A	LYS286
A	HOH1009
A	HOH1105
A	HOH1874
A	THR284

---

site_id	AD7
Number of Residues	5
Details	binding site for residue GOL A 916

Chain	Residue
A	TRP74
A	GOL914
A	HOH1016
A	HOH1142
A	HOH1589

---

site_id	AD8
Number of Residues	6
Details	binding site for residue GOL A 917

Chain	Residue
A	LEU532
A	TRP546
A	ASP566
A	ALA567
A	SER570
A	NA910

---

site_id	AD9
Number of Residues	5
Details	binding site for residue GOL A 918

Chain	Residue
A	GLN164
A	ASP452
A	TYR454
A	NA904
A	HOH1022

---

site_id	AE1
Number of Residues	6
Details	binding site for residue GOL A 919

Chain	Residue
A	LEU61
A	VAL62
A	TRP74
A	ARG669
A	GLU671
A	GOL914

---

site_id	AE2
Number of Residues	5
Details	binding site for residue GOL A 920

Chain	Residue
A	MET260
A	TYR376
A	TYR381
A	GLU382
A	ARG825

---

site_id	AE3
Number of Residues	5
Details	binding site for residue MLI A 921

Chain	Residue
A	PHE704
A	LYS738
A	TRP739
A	HOH1020
A	HOH1586

---

site_id	AE4
Number of Residues	8
Details	binding site for residue MLI A 922

Chain	Residue
A	ASN259
A	LYS274
A	PRO779
A	ASN780
A	ARG783
A	HOH1018
A	HOH1257
A	HOH1295

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHEYFHNW

Chain	Residue	Details
A	VAL294-TRP303

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"16885166","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18416562","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19622865","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---