4XKJ
a Novel D-lactate Dehydrogenase from Sporolactobacillus sp
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004617 | molecular_function | phosphoglycerate dehydrogenase activity |
| A | 0008720 | molecular_function | D-lactate dehydrogenase (NAD+) activity |
| A | 0009070 | biological_process | serine family amino acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0047545 | molecular_function | 2-hydroxyglutarate dehydrogenase activity |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004617 | molecular_function | phosphoglycerate dehydrogenase activity |
| B | 0008720 | molecular_function | D-lactate dehydrogenase (NAD+) activity |
| B | 0009070 | biological_process | serine family amino acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0047545 | molecular_function | 2-hydroxyglutarate dehydrogenase activity |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue NAD A 401 |
| Chain | Residue |
| A | TYR101 |
| A | ARG179 |
| A | HIS204 |
| A | VAL205 |
| A | PRO206 |
| A | THR211 |
| A | ALA232 |
| A | SER233 |
| A | ARG234 |
| A | ASP258 |
| A | HIS295 |
| A | VAL106 |
| A | GLY297 |
| A | PHE298 |
| A | GLY152 |
| A | ALA153 |
| A | GLY154 |
| A | ARG155 |
| A | ILE156 |
| A | ASP175 |
| A | ILE176 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | binding site for residue NAD B 401 |
| Chain | Residue |
| B | TYR101 |
| B | VAL106 |
| B | GLY152 |
| B | ALA153 |
| B | ARG155 |
| B | ILE156 |
| B | ASP175 |
| B | ILE176 |
| B | HIS204 |
| B | VAL205 |
| B | PRO206 |
| B | SER210 |
| B | THR211 |
| B | ALA232 |
| B | SER233 |
| B | ARG234 |
| B | ASP258 |
| B | HIS295 |
| B | PHE298 |
Functional Information from PROSITE/UniProt
| site_id | PS00670 |
| Number of Residues | 23 |
| Details | D_2_HYDROXYACID_DH_2 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. LLqaADVVtLHvPlmdsTtqLiD |
| Chain | Residue | Details |
| A | LEU194-ASP216 |
| site_id | PS00671 |
| Number of Residues | 17 |
| Details | D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MKnDaVLINaSRGpVVD |
| Chain | Residue | Details |
| A | MET223-ASP239 |
