4XJ5

Crystal structure of Vibrio cholerae DncV 3'-deoxy GTP bound form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0140701	molecular_function	3',3'-cyclic GMP-AMP synthase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG A 1001

Chain	Residue
A	ASP131
A	ASP133
A	GH31014
A	HOH1282

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 1002

Chain	Residue
A	HOH1303
A	ASP131
A	ASP133
A	ASP193
A	GH31013
A	GH31014

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 1003

Chain	Residue
A	ALA292
A	ASN394
A	MET395
A	GLY398
A	HOH1221

---

site_id	AC4
Number of Residues	6
Details	binding site for residue EDO A 1004

Chain	Residue
A	GLY297
A	GLY298
A	SER300
A	HOH1127
A	HOH1188
A	HOH1253

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 1005

Chain	Residue
A	LYS277
A	ALA316
A	GLU324

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 1006

Chain	Residue
A	MET3
A	TRP5
A	GLU381
A	SER382
A	ALA383

---

site_id	AC7
Number of Residues	8
Details	binding site for residue EDO A 1007

Chain	Residue
A	PHE64
A	TRP294
A	ASP295
A	VAL296
A	HOH1116
A	HOH1120
A	HOH1141
A	HOH1197

---

site_id	AC8
Number of Residues	8
Details	binding site for residue EDO A 1008

Chain	Residue
A	LYS29
A	SER114
A	PHE115
A	ASP118
A	THR119
A	LEU120
A	ARG284
A	HOH1183

---

site_id	AC9
Number of Residues	1
Details	binding site for residue EDO A 1009

Chain	Residue
A	ARG108

---

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO A 1010

Chain	Residue
A	SER314
A	HIS332
A	GLU336
A	HOH1340

---

site_id	AD2
Number of Residues	6
Details	binding site for residue EDO A 1011

Chain	Residue
A	PHE7
A	TYR11
A	GLY323
A	LEU377
A	GLU381
A	ILE393

---

site_id	AD3
Number of Residues	9
Details	binding site for residue EDO A 1012

Chain	Residue
A	LYS277
A	HIS317
A	ASP318
A	ALA319
A	HOH1106
A	HOH1106
A	HOH1132
A	HOH1137
A	HOH1256

---

site_id	AD4
Number of Residues	10
Details	binding site for residue GH3 A 1013

Chain	Residue
A	GLN112
A	ASP133
A	LYS177
A	THR179
A	CYS180
A	ASP193
A	TYR197
A	SER259
A	MG1002
A	GH31014

---

site_id	AD5
Number of Residues	24
Details	binding site for residue GH3 A 1014

Chain	Residue
A	GLN112
A	GLY113
A	SER114
A	TYR117
A	ASP131
A	ASP133
A	LYS287
A	SER301
A	ASP348
A	LEU352
A	MG1001
A	MG1002
A	GH31013
A	HOH1184
A	HOH1199
A	HOH1207
A	HOH1250
A	HOH1272
A	HOH1279
A	HOH1282
A	HOH1283
A	HOH1284
A	HOH1286
A	HOH1303

---

site_id	AD6
Number of Residues	5
Details	binding site for residue NA A 1015

Chain	Residue
A	TRP289
A	LYS369
A	LEU373
A	ILE376
A	HOH1181

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25865248","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25865248","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TXY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TXZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TY0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25865248","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---