4XF2

Tetragonal structure of Arp2/3 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005885	cellular_component	Arp2/3 protein complex
A	0010592	biological_process	positive regulation of lamellipodium assembly
A	0030030	biological_process	cell projection organization
A	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
A	0035861	cellular_component	site of double-strand break
A	0042995	cellular_component	cell projection
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0051015	molecular_function	actin filament binding
A	0060271	biological_process	cilium assembly
B	0003779	molecular_function	actin binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005885	cellular_component	Arp2/3 protein complex
B	0005938	cellular_component	cell cortex
B	0010592	biological_process	positive regulation of lamellipodium assembly
B	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
B	0035861	cellular_component	site of double-strand break
B	0042995	cellular_component	cell projection
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0051015	molecular_function	actin filament binding
B	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
B	2001032	biological_process	regulation of double-strand break repair via nonhomologous end joining
C	0003779	molecular_function	actin binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005885	cellular_component	Arp2/3 protein complex
C	0015629	cellular_component	actin cytoskeleton
C	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
C	0051015	molecular_function	actin filament binding
D	0003779	molecular_function	actin binding
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005885	cellular_component	Arp2/3 protein complex
D	0015629	cellular_component	actin cytoskeleton
D	0030041	biological_process	actin filament polymerization
D	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
D	0035861	cellular_component	site of double-strand break
D	0042995	cellular_component	cell projection
D	0043005	cellular_component	neuron projection
D	0045202	cellular_component	synapse
D	0051015	molecular_function	actin filament binding
E	0003779	molecular_function	actin binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005885	cellular_component	Arp2/3 protein complex
E	0030833	biological_process	regulation of actin filament polymerization
E	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
E	0035861	cellular_component	site of double-strand break
E	0042995	cellular_component	cell projection
E	0051015	molecular_function	actin filament binding
F	0003779	molecular_function	actin binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005885	cellular_component	Arp2/3 protein complex
F	0015629	cellular_component	actin cytoskeleton
F	0030041	biological_process	actin filament polymerization
F	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
F	0035861	cellular_component	site of double-strand break
F	0042995	cellular_component	cell projection
F	0051015	molecular_function	actin filament binding
G	0003779	molecular_function	actin binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005885	cellular_component	Arp2/3 protein complex
G	0015629	cellular_component	actin cytoskeleton
G	0016477	biological_process	cell migration
G	0030833	biological_process	regulation of actin filament polymerization
G	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
G	0035861	cellular_component	site of double-strand break
G	0042995	cellular_component	cell projection
G	0051015	molecular_function	actin filament binding
T	0003779	molecular_function	actin binding
T	0005515	molecular_function	protein binding
T	0005524	molecular_function	ATP binding
T	0005634	cellular_component	nucleus
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005856	cellular_component	cytoskeleton
T	0005885	cellular_component	Arp2/3 protein complex
T	0010592	biological_process	positive regulation of lamellipodium assembly
T	0030030	biological_process	cell projection organization
T	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
T	0035861	cellular_component	site of double-strand break
T	0042995	cellular_component	cell projection
T	0045944	biological_process	positive regulation of transcription by RNA polymerase II
T	0051015	molecular_function	actin filament binding
T	0060271	biological_process	cilium assembly
U	0003779	molecular_function	actin binding
U	0005515	molecular_function	protein binding
U	0005524	molecular_function	ATP binding
U	0005634	cellular_component	nucleus
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005856	cellular_component	cytoskeleton
U	0005885	cellular_component	Arp2/3 protein complex
U	0005938	cellular_component	cell cortex
U	0010592	biological_process	positive regulation of lamellipodium assembly
U	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
U	0035861	cellular_component	site of double-strand break
U	0042995	cellular_component	cell projection
U	0045944	biological_process	positive regulation of transcription by RNA polymerase II
U	0051015	molecular_function	actin filament binding
U	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
U	2001032	biological_process	regulation of double-strand break repair via nonhomologous end joining
V	0003779	molecular_function	actin binding
V	0005634	cellular_component	nucleus
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0005856	cellular_component	cytoskeleton
V	0005885	cellular_component	Arp2/3 protein complex
V	0015629	cellular_component	actin cytoskeleton
V	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
V	0051015	molecular_function	actin filament binding
W	0003779	molecular_function	actin binding
W	0005200	molecular_function	structural constituent of cytoskeleton
W	0005634	cellular_component	nucleus
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005856	cellular_component	cytoskeleton
W	0005885	cellular_component	Arp2/3 protein complex
W	0015629	cellular_component	actin cytoskeleton
W	0030041	biological_process	actin filament polymerization
W	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
W	0035861	cellular_component	site of double-strand break
W	0042995	cellular_component	cell projection
W	0043005	cellular_component	neuron projection
W	0045202	cellular_component	synapse
W	0051015	molecular_function	actin filament binding
X	0003779	molecular_function	actin binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005856	cellular_component	cytoskeleton
X	0005885	cellular_component	Arp2/3 protein complex
X	0030833	biological_process	regulation of actin filament polymerization
X	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
X	0035861	cellular_component	site of double-strand break
X	0042995	cellular_component	cell projection
X	0051015	molecular_function	actin filament binding
Y	0003779	molecular_function	actin binding
Y	0005634	cellular_component	nucleus
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0005856	cellular_component	cytoskeleton
Y	0005885	cellular_component	Arp2/3 protein complex
Y	0015629	cellular_component	actin cytoskeleton
Y	0030041	biological_process	actin filament polymerization
Y	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
Y	0035861	cellular_component	site of double-strand break
Y	0042995	cellular_component	cell projection
Y	0051015	molecular_function	actin filament binding
Z	0003779	molecular_function	actin binding
Z	0005634	cellular_component	nucleus
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0005856	cellular_component	cytoskeleton
Z	0005885	cellular_component	Arp2/3 protein complex
Z	0015629	cellular_component	actin cytoskeleton
Z	0016477	biological_process	cell migration
Z	0030833	biological_process	regulation of actin filament polymerization
Z	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
Z	0035861	cellular_component	site of double-strand break
Z	0042995	cellular_component	cell projection
Z	0051015	molecular_function	actin filament binding

Functional Information from PROSITE/UniProt

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEPpLNTpeNR

Chain	Residue	Details
A	LEU111-ARG123
B	LEU108-ARG120

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylserine => ECO:0000250|UniProtKB:O15511

Chain	Residue	Details
G	SER2
Z	SER2
W	LYS275
W	LYS295
U	ARG214
U	GLY305

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O15145

Chain	Residue	Details
E	LYS56
E	LYS61
X	LYS56
X	LYS61
T	LYS240
T	LYS244
T	LYS251
T	LYS254

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:O15145

Chain	Residue	Details
E	LYS14
B	LYS322
X	LYS14
U	LYS322

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